- “It’s getting hot in here: the interface between obesity, influenza and thermoneutrality”. David N O’Dwyerby inmunoadminMucosal Immunol. 2023 Oct 27:S1933-0219(23)00081-8. doi: 10.1016/j.mucimm.2023.10.003. Online ahead of print. NO ABSTRACT PMID:39491094 | DOI:10.1016/j.mucimm.2023.10.003
- Disrupting endogenous retroelements with a reverse transcriptase inhibitor alleviates DSS-induced colitis in mice. Yifan Niuby inmunoadminMucosal Immunol. 2023 Oct 27:S1933-0219(23)00082-X. doi: 10.1016/j.mucimm.2023.10.004. Online ahead of print. ABSTRACT Endogenous retroelements play vital roles in sustaining immune homeostasis. Activation of endogenous retroelements can trigger cGAS/STING pathway and downstream pro-inflammatory cytokine production. M1 macrophages, which can be induced by pro-inflammatory cytokines, are involved in the development of colitis. Here we aimed to determine … Read more
- Airway macrophage glycolysis controls lung homeostasis and responses to aeroallergen. Gesa J Albersby inmunoadminMucosal Immunol. 2024 Oct 17:S1933-0219(24)00105-3. doi: 10.1016/j.mucimm.2024.10.002. Online ahead of print. ABSTRACT The lungs represent a dynamic microenvironment where airway macrophages (AMs) are the major lung-resident macrophages. AMs dictate the balance between tissue homeostasis and immune activation and thus have contradictory functions by maintaining tolerance and tissue homeostasis, as well as initiating strong inflammatory responses. … Read more
- RelB and C/EBPα critically regulate the development of Peyer’s patch mononuclear phagocytes. Takashi Kanayaby inmunoadminMucosal Immunol. 2024 Oct 14:S1933-0219(24)00108-9. doi: 10.1016/j.mucimm.2024.10.005. Online ahead of print. ABSTRACT To establish protection against harmful foreign antigens, the small intestine harbors guardian sites called Peyer’s patches (PPs). PPs take up antigens through microfold (M) cells and transfer them to the sub-epithelial dome (SED), which contains a high density of mononuclear phagocytes (MPs), for … Read more
- TRIM29 controls enteric RNA virus-induced intestinal inflammation by targeting NLRP6 and NLRP9b signaling pathways. Junying Wangby inmunoadminMucosal Immunol. 2024 Oct 11:S1933-0219(24)00107-7. doi: 10.1016/j.mucimm.2024.10.004. Online ahead of print. ABSTRACT Infections by enteric virus and intestinal inflammation are recognized as a leading cause of deadly gastroenteritis, and NLRP6 and NLRP9b signaling control these infection and inflammation. However, the regulatory mechanisms of the NLRP6 and NLRP9b signaling in enteric viral infection remain unexplored. In … Read more
- A reappraisal of IL-9 in inflammation and cancer. Fabian Bickby inmunoadminMucosal Immunol. 2024 Oct 8:S1933-0219(24)00106-5. doi: 10.1016/j.mucimm.2024.10.003. Online ahead of print. ABSTRACT While much is known about the functional effects of type 2 cytokines interleukin (IL)-4, IL-5 and IL-13 in homeostasis and disease, we still poorly understand the functions of IL-9. Chronic inflammation seen in allergic diseases, autoimmunity and cancer is however frequently accompanied by … Read more
- Sensory neuroimmune interactions at the barrier. Zhen Wangby inmunoadminMucosal Immunol. 2024 Oct 5:S1933-0219(24)00104-1. doi: 10.1016/j.mucimm.2024.10.001. Online ahead of print. ABSTRACT Epithelial barriers such as the skin, lung, and gut, in addition to having unique physiologic functions, are designed to preserve tissue homeostasis upon challenge with a variety of allergens, irritants, or pathogens. Both the innate and adaptive immune systems play a critical role … Read more
- CSF1-dependent macrophage support matrisome and epithelial stress-induced keratin remodeling in Eosinophilic esophagitis. Taylor M Bensonby inmunoadminMucosal Immunol. 2024 Sep 27:S1933-0219(24)00099-0. doi: 10.1016/j.mucimm.2024.09.006. Online ahead of print. ABSTRACT Atopic diseases such as Eosinophilic Esophagitis (EoE) often progress into fibrosis (FS-EoE), compromising organ function with limited targeted treatment options. Mechanistic understanding of FS-EoE progression is confounded by the lack of preclinical models and the heavy focus of research on eosinophils themselves. We … Read more
- Controlling functional homeostasis of ileal resident macrophages by vitamin B12 during steady state and Salmonella infection in mice. Yong Geby inmunoadminMucosal Immunol. 2024 Sep 8:S1933-0219(24)00091-6. doi: 10.1016/j.mucimm.2024.08.011. Online ahead of print. ABSTRACT Dietary micronutrients, particularly vitamin B12 (VB12), profoundly influence the physiological maintenance and function of intestinal cells. However, it is still unclear whether VB12 modulates the transcriptional and metabolic programming of ileal macrophages (iMacs), thereby contributing to intestinal homeostasis. Using multiomic approaches, we demonstrated … Read more
- The kynurenine pathway regulated by intestinal innate lymphoid cells mediates postoperative cognitive dysfunction. Wan-Bing Daiby inmunoadminMucosal Immunol. 2024 Sep 7:S1933-0219(24)00095-3. doi: 10.1016/j.mucimm.2024.09.002. Online ahead of print. ABSTRACT Postoperative cognitive dysfunction (POCD) is a prevalent neurological complication that can impair learning and memory for days, months, or even years after anesthesia/surgery. POCD is strongly associated with an altered composition of the gut microbiota (dysbiosis), but the accompanying metabolic changes and their … Read more
- MicroRNA-142 regulates gut associated lymphoid tissues and group 3 innate lymphoid cells. Luke B Robertsby inmunoadminMucosal Immunol. 2024 Sep 7:S1933-0219(24)00094-1. doi: 10.1016/j.mucimm.2024.09.001. Online ahead of print. ABSTRACT The transcriptomic signatures that shape responses of innate lymphoid cells (ILCs) have been well characterised, however post-transcriptional mechanisms which regulate their development and activity remain poorly understood. We demonstrate that ILC groups of the intestinal lamina propria express mature forms of microRNA-142 (miR-142), … Read more
- Dysregulated NOX1-NOS2 activity as hallmark of ileitis in mice. Julie Drieu La Rochelleby inmunoadminMucosal Immunol. 2024 Sep 7:S1933-0219(24)00093-X. doi: 10.1016/j.mucimm.2024.08.012. Online ahead of print. ABSTRACT Inflammation of the ileum, or ileitis, is commonly caused by Crohn’s disease (CD) but can also accompany ulcerative colitis (backwash ileitis), infections or drug-related damage. Oxidative tissue injury triggered by reactive oxygen species (ROS) is considered part of the ileitis etiology. However, not … Read more
- Dietary fiber promotes antigen presentation on intestinal epithelial cells and development of small intestinal CD4+CD8αα+ intraepithelial T cells. Naomi Rodriguez-Marinoby inmunoadminMucosal Immunol. 2024 Sep 5:S1933-0219(24)00092-8. doi: 10.1016/j.mucimm.2024.08.010. Online ahead of print. ABSTRACT The impact of dietary fiber on intestinal T cell development is poorly understood. Here we show that a low fiber diet reduces MHC-II antigen presentation by small intestinal epithelial cells (IECs) and consequently impairs development of CD4+CD8αα+ intraepithelial lymphocytes (DP IELs) through changes … Read more
- Deciphering the therapeutic potential of Myeloid-Specific JAK2 inhibition in acute respiratory distress syndrome. Shupei Gaoby inmunoadminMucosal Immunol. 2024 Aug 21:S1933-0219(24)00089-8. doi: 10.1016/j.mucimm.2024.08.008. Online ahead of print. ABSTRACT Acute respiratory distress syndrome (ARDS) is a life-threatening condition characterized by severe inflammation and pulmonary dysfunction. Despite advancements in critical care, effective pharmacological interventions for ARDS remain elusive. While Janus kinase 2 (JAK2) inhibitors have emerged as an innovative treatment for numerous autoinflammatory … Read more
- CSF1R inhibition by PLX5622 reduces pulmonary fungal infection by depleting MHCIIhi interstitial lung macrophages. Sally H Mohamedby inmunoadminMucosal Immunol. 2024 Aug 20:S1933-0219(24)00088-6. doi: 10.1016/j.mucimm.2024.08.007. Online ahead of print. ABSTRACT PLX5622 is a small molecular inhibitor of the CSF1 receptor (CSF1R) and is widely used to deplete macrophages within the central nervous system (CNS). We investigated the impact of PLX5622 treatment in wild-type C57BL/6 mice and discovered that one-week treatment with PLX5622 was … Read more
- Combined plasma protein and Tmem profiling discern IBD-patient-immunotypes related to intestinal disease and treatment outcomes: Short title: Defining immunotypes in CD and UC. Maud Herediaby inmunoadminMucosal Immunol. 2024 Sep 25:S1933-0219(24)00097-7. doi: 10.1016/j.mucimm.2024.09.004. Online ahead of print. ABSTRACT Inflammatory bowel disease (IBD) chronicity results from memory T helper cell (Tmem) reactivation. Identifying patient-specific immunotypes is crucial for tailored treatment. We conducted a comprehensive study integrating circulating immune proteins and circulating Tmem, with intestinal tissue histology and mRNA analysis, in therapy-naïve pediatric … Read more
- Dissecting the metabolic signaling pathways by which microbial molecules drive the differentiation of regulatory B cells. Maik Luuby inmunoadminMucosal Immunol. 2024 Sep 16:S1933-0219(24)00096-5. doi: 10.1016/j.mucimm.2024.09.003. Online ahead of print. ABSTRACT The host-microbiome axis has been implicated in promoting anti-inflammatory immune responses. Yet, the underlying molecular mechanisms of commensal-mediated IL-10 production by regulatory B cells (Bregs) are not fully elucidated. Here, we demonstrate that bacterial CpG motifs trigger the signaling downstream of TLR9 promoting … Read more
- Dysregulated myeloid differentiation in colitis is induced by inflammatory osteoclasts in a TNFα-dependent manner. Maria-Bernadette Madelby inmunoadminMucosal Immunol. 2024 Sep 25:S1933-0219(24)00098-9. doi: 10.1016/j.mucimm.2024.09.005. Online ahead of print. ABSTRACT Inflammatory bowel disease (IBD) is characterized by very severe intestinal inflammation associated with extra-intestinal manifestations. One of the most critical ones is bone destruction, which remains a major cause of morbidity and a risk factor for osteopenia and osteoporosis in IBD patients. In … Read more
- Mucosal immunization with a delta-inulin adjuvanted recombinant spike vaccine elicits lung-resident immune memory and protects mice against SARS-CoV-2by Erica L. StewartMucosal Immunology, Published online: 21 November 2022; doi:10.1038/s41385-022-00578-9Mucosal immunization with a delta-inulin adjuvanted recombinant spike vaccine elicits lung-resident immune memory and protects mice against SARS-CoV-2
- Intestinal epithelium in early lifeby Lauren C. FrazerMucosal Immunology, Published online: 15 November 2022; doi:10.1038/s41385-022-00579-8Intestinal epithelium in early life
- Epithelial dysfunction is prevented by IL-22 treatment in a <i>Citrobacter rodentium</i>-induced colitis model that shares similarities with inflammatory bowel diseaseby Qifan ZhuMucosal Immunology, Published online: 13 November 2022; doi:10.1038/s41385-022-00577-wEpithelial dysfunction is prevented by IL-22 treatment in a Citrobacter rodentium-induced colitis model that shares similarities with inflammatory bo…
- Severity of neonatal influenza infection is driven by type I interferon and oxidative stressby Ogan K. KumovaMucosal Immunology, Published online: 09 November 2022; doi:10.1038/s41385-022-00576-xSeverity of neonatal influenza infection is driven by type I interferon and oxidative stress
- Resistance is futile? Mucosal immune mechanisms in the context of microbial ecology and evolutionby Emma SlackMucosal Immunology, Published online: 03 November 2022; doi:10.1038/s41385-022-00574-zResistance is futile? Mucosal immune mechanisms in the context of microbial ecology and evolution
- Hermansky-Pudlak syndrome type 1 causes impaired anti-microbial immunity and inflammation due to dysregulated immunometabolismby Athena CavounidisMucosal Immunology, Published online: 27 October 2022; doi:10.1038/s41385-022-00572-1Hermansky-Pudlak syndrome type 1 causes impaired anti-microbial immunity and inflammation due to dysregulated immunometabolism
- A new age for (mucosal) NeuroImmunologyby Gerard EberlMucosal Immunology, Published online: 18 October 2022; doi:10.1038/s41385-022-00573-0A new age for (mucosal) NeuroImmunology
- John Bienenstock Obituaryby Pearay L. OgraMucosal Immunology, Published online: 14 October 2022; doi:10.1038/s41385-022-00571-2John Bienenstock Obituary