- An antigen-less pro-vaccine for treating autoimmunityby inmunoadminJ Immunol. 2025 Apr 24:vkaf068. doi: 10.1093/jimmun/vkaf068. Online ahead of print. ABSTRACT We have designed the first antigen-less pro-vaccine, named 8206, for treating autoimmune diseases. Composed of dexamethasone, rapamycin, and R848 at a mass ratio of 8:20:6, 8206 is a complete tolerogenic adjuvant that acts systemically to form an active vaccine in situ with endogenous … Read more
- Presence of LILRB4 SNP rs1048801 modulates Acute Myeloid Leukemia progression and inhibits CD4+ T cells proliferationZhiyong Zhou on 25 de April de 2025 at 10:00by inmunoadminJ Leukoc Biol. 2025 Apr 25:qiaf052. doi: 10.1093/jleuko/qiaf052. Online ahead of print. ABSTRACT Leukocyte immunoglobulin-like receptor subfamily B member 4 (LILRB4), an emerging immune checkpoint molecule, exhibits therapeutic potential in acute myeloid leukemia (AML). While single nucleotide polymorphisms (SNPs) of immune checkpoint genes have been extensively investigated in AML, the association between LILRB4 genetic polymorphisms … Read more
- Depression-like behavior is associated with changes in the meningeal lymphatic vasculature and meningeal B cells in a murine lupus modelAlexandra Olate-Briones on 25 de April de 2025 at 10:00by inmunoadminJ Leukoc Biol. 2025 Apr 23;117(4):qiaf016. doi: 10.1093/jleuko/qiaf016. ABSTRACT Meningeal lymphatic vasculature (mLV) comprises a network of vessels responsible for draining immune cells and fluid from the central nervous system (CNS) into the deep cervical lymph nodes. While changes in mLV function have been implicated in several neurodegenerative disorders, its role in autoimmune diseases is … Read more
- Protective function of ex vivo-expanded CD8 T cells in a mouse model of adoptive therapy for cytomegalovirus infection depends on integrin beta 1 but not CXCR3, CTLA4, or PD-1 expressionXiaokun Liu on 25 de April de 2025 at 10:00by inmunoadminJ Leukoc Biol. 2025 Apr 23;117(4):qiae256. doi: 10.1093/jleuko/qiae256. ABSTRACT The adoptive transfer of virus-specific T cells (VSTs) represents a therapeutic option for viral infection treatment in immunocompromised patients. Before administration, ex vivo culture enables VST expansion. However, it is unclear how ex vivo expansion affects the circulation, homing, and intra-tissue migration of administered VSTs. We … Read more
- Different behavior of NK cells isolated from healthy women and women with recurrent spontaneous abortion after treatment with human amniotic epithelial cellsFatemeh Rezayat on 25 de April de 2025 at 10:00by inmunoadminJ Leukoc Biol. 2025 Apr 23;117(4):qiaf020. doi: 10.1093/jleuko/qiaf020. ABSTRACT Maternal immunotolerance during pregnancy is heavily dependent on the critical properties of human amniotic epithelial cells (hAECs). Recurrent spontaneous abortion (RSA) is one of the most common diseases in women and is caused by feto-maternal immunotolerance disruption. The objective of this study is to investigate how … Read more