Trends in Immunology

Background Multiple myeloma (MM) is a hematologic malignancy characterized by a high relapse rate despite recent therapeutic advances. B-cell maturation antigen (BCMA) and G protein-coupled receptor class C group 5 member D (GPRC5D) are two well-valid…

Background Limited durability of clinical responses remains a major challenge in chimeric antigen receptor (CAR)-T therapy. CAR-enhancers (CAR-Es), which fuse tumor antigens to interleukin (IL)-2 muteins, provide a targeted strategy to enhance CAR-T p…

Curr Opin Immunol. 2026 Feb 16;99:102739. doi: 10.1016/j.coi.2026.102739. Online ahead of print. ABSTRACT Sjögren’s disease (SjD) is a chronic, systemic autoimmune disease that mainly targets saliva- and tear-producing glands. T-cells are a substantial immune cell subset involved in SjD pathogenesis, including break of tolerance toward self, and constitute a major part of tissue-resident and infiltrating … Read more

BackgroundMacrophages are dynamic immune cells whose phenotype and function are shaped by environmental cues, including inflammatory stimuli and oxidative stress. A major source of macrophage-derived reactive oxygen species (ROS) is NADPH Oxidase 2 (NO…

BackgroundBioprosthetic heart valves (BHVs) are widely used in cardiac surgery but are limited by structural valve deterioration (SVD). The Translink study showed that immune responses to xenogeneic glycans contribute to SVD. Hyaluronan (HA), a glycosa…