Cancer Immunol Res. 2026 Jun 30. doi: 10.1158/2326-6066.CIR-25-1602. Online ahead of print. ABSTRACT Macrophages constitute a dominant and functionally diverse immune population within the microenvironment of pancreatic ductal adenocarcinoma (PDAC), yet how macrophage heterogeneity contributes to the tumor remains poorly defined. In an institutional cohort of 145 PDAC specimens, we identified a population of multinucleated … Read more
Background
Metabolic competition and nutrient restriction in the tumor microenvironment (TME) shape the immune infiltrate in tumors and subsequently tumor immunity. In this study we used the transgenic melanoma mouse model tg(Grm1)EPv, which spontaneo…
J Leukoc Biol. 2026 Jun 8;118(6):qiag057. doi: 10.1093/jleuko/qiag057. ABSTRACT Therapeutic modulation of sepsis-induced immune dysfunction by targeting lymphocyte dysfunction with recombinant IL-7 (rIL-7) and anti-PD-1 (e.g. nivolumab) has shown promise in preclinical and early clinical studies. Prior to conducting large randomized controlled trials, an in-depth understanding of the changes induced by rIL-7 or nivolumab (and … Read more
Nature Reviews Immunology, Published online: 30 June 2026; doi:10.1038/s41577-026-01333-yA preprint by Serganova, Colombo et al. shows that tumour glycolytic capacity drives vascular abnormalities that influence the response to immunot…
Nature Reviews Immunology, Published online: 30 June 2026; doi:10.1038/s41577-026-01332-zA preprint by Vick et al. reports a crucial role for vaginal NK cells in maintaining epithelial integrity during infection.
Nature Reviews Immunology, Published online: 30 June 2026; doi:10.1038/s41577-026-01328-9In this Viewpoint, eight experts from the field of T cell exhaustion discuss current understanding of the self-renewing population of PD1+TCF1+TOX…
Nature Reviews Immunology, Published online: 30 June 2026; doi:10.1038/s41577-026-01318-xT cell engagers reprogramme T cells to eliminate pathogenic cell populations and are now emerging as a promising biologic strategy for autoimmune …
J Immunol. 2026 Jun 7;215(6):vkag165. doi: 10.1093/jimmun/vkag165. ABSTRACT Pancreatic ductal adenocarcinoma (PDAC) is characterized by an immunosuppressive tumor microenvironment (TME) in which cancer-associated fibroblasts (CAFs) play pivotal roles in shaping therapeutic responses. Among these, MHC-II-expressing antigen-presenting CAFs (apCAFs) modulate CD4 T-cell activity, yet their contribution to the antitumor immune response remains unclear. Using tumor clones … Read more
Highly sensitized kidney transplant candidates are difficult to transplant because anti-human leukocyte antigen (HLA) sensitization restricts access to immunologically compatible organs, as transplantation across donor-specific antibodies (DSA) increas…
Avian leukosis virus (ALV) remains a major threat to the poultry industry due to its ability to establish persistent infection, induce immunosuppression, and promote tumorigenesis. Despite progress in eradication programs, effective control is hindered…
Individuals living with HIV/AIDS may be more susceptible to various opportunistic infections due to an immunocompromised status, which can result in diverse clinical manifestations. Among potential pathogens, Mycobacterium colombiense—a slow-growing ba…
IntroductionGlobally, 15-30% of patients with chronic hepatitis C develop compensated advanced chronic liver disease (cACLD). cACLD may further advance to decompensated ACLD (dACLD), which is associated with higher liver-related mortality, even after s…
BackgroundThe present study aimed to characterize neurofibromatosis type 1 (NF1)-associated alterations in peripheral white blood cell differentials, focusing on overall patterns and sex-related differences.MethodsWe analyzed 225 Japanese patients with…
Johne’s disease, caused by Mycobacterium avium subsp. paratuberculosis (MAP), is a chronic enteric infection of ruminants characterized by persistence in intestinal macrophages following invasion through Peyer’s patches. Early studies established a pre…
BackgroundHemorrhagic fever with renal syndrome (HFRS) requires early risk stratification, yet the comparative value and reproducibility of complete blood count (CBC)-derived inflammatory indices remain unclear. We compared admission neutrophil-to-lymp…
BackgroundWD-repeat domain 1 (WDR1), a key regulator of actin cytoskeleton dynamics, has been implicated in tumor progression. However, its pan-cancer characteristics and immunological relevance remain unclear. In this study, we performed an integrativ…
IntroductionPyogenic spondylitis (PS) accompanies with diverse destruction, especially the subsequent bone destruction, which leads to spine instability and severe neurological disability. However, the mechanism underlying bone loss induced by infectio…
Gynecological malignancies represent a significant global health burden for women worldwide. Tumor-associated macrophages (TAMs), as a critical component of the immune system, play a pivotal role within the tumor microenvironment (TME). Modulating sign…
ObjectiveTo investigate the role and potential mechanism of CD200 in the pathogenesis of preeclampsia (PE) and to clarify its potential value as a biomarker candidate and possible therapeutic target for PE.MethodsThis retrospective study enrolled 57 pa…
High-dose (HD) influenza vaccines have demonstrated robust effectiveness in preventing severe influenza-related outcomes, including pneumonia, cardiorespiratory complications, and mortality, with evidence from randomized clinical trials, meta-analyses,…
IntroductionType 2 diabetes mellitus (T2DM) develops due to multiple factors, including dietary and lifestyle habits and genetic predisposition. In addition, alterations in the immune system have been suggested to be involved in the onset and progressi…
BackgroundInterleukin-1 (IL-1) cytokines as well as IL-1 genes are key regulators of neuroinflammation in Multiple Sclerosis (MS), with emerging roles in synaptic plasticity and tissue repair. While genetic determinants of MS susceptibility have been e…
BackgroundMetabolic reprogramming and epigenetic alterations contribute to the aggressiveness of human bladder cancer (BC). Lactate-dependent histone modification represents a novel class of histone marks that links the glycolytic metabolite to the epi…
Acute hepatopancreatic necrosis disease (AHPND), caused by Vibrio parahaemolyticus, poses a severe threat to global shrimp aquaculture. Reduced susceptibility of aquaculture-associated bacterial pathogens to conventional antibiotics, together with conc…
Although immune checkpoint blockade (ICB) has changed treatment strategies for gastric adenocarcinoma (STAD), many patients show primary resistance. Tumor-intrinsic transcriptional heterogeneity may contribute to immune escape, but the malignant-cell p…
Mycobacterium tuberculosis (Mtb) remains the leading cause of death from a single infectious agent, despite the availability of the Bacillus Calmette-Guérin (BCG) vaccine and antibiotic therapies. New tuberculosis (TB) vaccines are urgently needed to e…
The therapeutic landscape of oncology has undergone a profound paradigm shift, transitioning from conventional cytotoxic regimens to a sophisticated era of precision immunotherapy. Despite the remarkable clinical success of immune checkpoint inhibitors…
The immune system operates within a dynamic physiological environment shaped by systemic regulatory signals, among which endocrine factors are increasingly recognized as important modulators of immune function. Although thyroid hormones are well known …
Pagetoid reticulosis (PR), also known as Woringer–Kolopp disease (WKD), is a rare subtype of cutaneous T-cell lymphoma. Due to its low incidence and non-specific clinical presentation, it is frequently prone to misdiagnosis. We report the case of a 53-…
The skin barrier serves as the body’s primary line of defense against exogenous insults and is critical for maintaining systemic homeostasis. Emerging evidence indicates that skin barrier dysfunction is not merely a secondary manifestation of psoriasis…
Autophagy plays paradoxical roles in breast cancer, functioning as both a stress-adaptive survival mechanism and a tumor-suppressive process depending on cellular and microenvironmental context. However, the molecular logic governing this functional du…
ObjectiveThis study aimed to systematically evaluate the bidirectional association between obstructive lung diseases (OLD) [including chronic obstructive pulmonary disease (COPD), asthma, and bronchiectasis] and inflammatory bowel disease (IBD) [includ…
BackgroundImmune checkpoint inhibitors (ICIs) have become a cornerstone of treatment for metastatic renal cell carcinoma (mRCC). Nivolumab monotherapy remains an established option in previously treated patients; however, real-world data (RWD) from Cen…
BackgroundCentral and peripheral inflammation are under intense investigation because of their increasing relationship with neuropsychiatric disorders and neurodegeneration. Microglia, the main component of the innate immune system within the brain, co…
BackgroundAcute myeloid leukemia (AML) is an aggressive hematologic malignancy with poor prognosis and significant heterogeneity. Lipid metabolic reprogramming is a key hallmark of cancer, yet its systemic characterization and clinical relevance in AML…
Curr Opin Immunol. 2026 Jun 29;101:102809. doi: 10.1016/j.coi.2026.102809. Online ahead of print. ABSTRACT The fate of T cells is determined through the expression of a unique T cell receptor (TCR). TCR epitope specificity drives spatial localization, phenotypic and metabolic plasticity, effector function, as well as the evolution of complex repertoires of T cell clones. However, … Read more
J Immunol. 2026 Jun 7;215(6):vkag158. doi: 10.1093/jimmun/vkag158. ABSTRACT In human melanoma, tumor cell-specific MHC class II expression is associated with improved response to programmed death 1 and programmed death-ligand 1 blockade; yet the direct effect of melanoma cell-specific MHC class II expression on anti-melanoma T cell responses remains largely unknown. In the clinically relevant Yale … Read more
J Immunol. 2026 Jun 7;215(6):vkag127. doi: 10.1093/jimmun/vkag127. ABSTRACT Downregulation of ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) has been implicated in autophagic cell death. However, how ENPP1 regulates the interplay between autophagy and ferroptosis to maintain trophoblast homeostasis in the context of gestational diabetes mellitus (GDM) remains unclear. To determine ENPP1’s role in autophagy-dependent ferroptosis and its contribution … Read more
J Leukoc Biol. 2026 Jun 29:qiag091. doi: 10.1093/jleuko/qiag091. Online ahead of print. ABSTRACT Eosinophils are highly granulated white blood cells first identified as “granule blood cells” in the 19th century. In this review, we discuss techniques used to identify these unique cells and explore how they release a range of pro- and anti-inflammatory mediators. They … Read more
J Leukoc Biol. 2026 Jun 8;118(6):qiag062. doi: 10.1093/jleuko/qiag062. ABSTRACT The immunotherapy represents the most promising new cancer treatment approach but due to the high heterogeneity of the tumor microenvironment among patients, only a small portion of patients respond to a certain immunotherapy. Therefore, identifying the immune-related subtypes and immune molecular characteristics is of great guiding … Read more
J Leukoc Biol. 2026 Jun 8;118(6):qiag075. doi: 10.1093/jleuko/qiag075. ABSTRACT Autologous cell therapy is a patient-embraced approach to inflammatory disease. Murine models demonstrate that alternatively activated (or regulatory) macrophages can reduce the severity of disease, and human macrophages (M0) educated with interleukin-4 (M(IL4)) limit murine colitis. M0 and M(IL4) from healthy donors and individuals with Crohn’s … Read more
Cancer Immunol Res. 2026 Jun 29:OF1-OF2. doi: 10.1158/2326-6066.CIR-26-0635. Online ahead of print. ABSTRACT Immune checkpoint inhibitors (ICI) have had a transformative impact on cancer treatment. However, many patients still fail to respond to ICIs, underscoring the need to identify novel drivers of resistance. In this issue, Ou and colleagues identify single-stranded DNA binding protein 4 … Read more
While conventionally viewed as a defense against external pathogens, we posit that the adaptive immune system likely evolved primarily to preserve internal epithelial order. We propose that adaptive immunity, with combinatorial diversity emerging ~0.5…
Background
Pembrolizumab 400 mg every 6 weeks (Q6W) was approved based on population pharmacokinetic (pop-PK) modeling rather than pharmacokinetic measurements, leaving real-world concentrations insufficiently characterized. The impact of concentratio…
Why are clonal neoantigens paradoxically rare in established tumors? Why does tumor-associated antigen (TAA) burden inversely correlate with T-cell infiltration? Why do damage-associated molecular pattern (DAMP)/danger signal-inducing interventions (m…
by Du, Y., Yang, L., Dai, H., Zhou, J., Zhou, Z., Yuan, R., Ye, R., Nguyen, A. T. Q., Bhatia, K., Lin, S.-Y.
Background
Despite the widespread adoption of chemoimmunotherapy in triple-negative breast cancer (TNBC), the mechanisms by which cytotoxic chemotherapy engages antitumor immunity remain poorly defined. Identifying tumor-intrinsic immunogenic programs…
J Clin Immunol. 2026 Jun 27. doi: 10.1007/s10875-026-02047-5. Online ahead of print. ABSTRACT TRNT1 deficiency (SIFD syndrome) is a rare inborn error of immunity characterized by sideroblastic anemia, immunodeficiency, periodic fevers, and developmental delay. We report two Romanian patients with genetically confirmed TRNT1 deficiency presenting with characteristic hematologic and immunologic abnormalities and a distinctive facial … Read more
Background
V9V2-T cells form a conserved T-cell subset known for its potent intrinsic antitumor activity and versatility in recognizing diverse cancer types independently of the major histocompatibility complex. Previously, we reported the preclinical…
by Zhang, Y., Sun, H., Yuan, Y., Liu, D., Qiao, J.
This study maps the global clinical trial landscape of cytokine-induced killer (CIK) cell therapy across malignancies and selected immune-related disorders, based on 199 interventional trials retrieved from the Informa database up to February 2026. An…
ObjectiveThis study aimed to characterize the immune profile of neonates with Kasabach-Merritt phenomenon (KMP) and to identify clinical features linked to severe thrombocytopenia in these patients.MethodsThis multicenter retrospective study included n…
N4-acetylcytidine (ac4C) is an evolutionarily conserved RNA modification catalyzed by N-acetyltransferase 10 (NAT10), representing the sole known acetylation modification in eukaryotic mRNA. Recent studies have revealed that ac4C modification plays mul…
BackgroundHead and neck squamous cell carcinoma (HNSC) present a significant treatment challenge due to variability in radiotherapy response, where glycolysis may play a pivotal role in modulating sensitivity. This study aimed to develop a glycolysis-a…
Complement component 3 (C3) plays a central role in innate immunity as a convergence point of the classical, alternative, and lectin pathways. Complete C3 deficiency is an extremely rare inborn error of immunity, typically associated with recurrent sev…
Non-alcoholic fatty liver disease (NAFLD) affects over 30% of the global adult population and has been increasingly recognized as an adverse prognostic factor for colorectal cancer (CRC) liver metastasis (CRLM). However, the underlying immune mechanism…
Background/objectivesThis study aimed to investigate the preventive and protective effect of Buyang Huanwu Decoction (BHD) against hypobaric hypoxia-induced brain injury in mice and to explore its underlying mechanisms. Particular emphasis was placed o…
BackgroundPeople living with HIV (PLWH) have an excess risk of cardiovascular disease (CVD), but little is known regarding intrinsic links between gut microbiota profiles, inflammatory factors, and the risk of carotid atherosclerosis in HIV infection w…
Multiple sclerosis (MS) has traditionally been conceptualized through an event-based framework in which relapses, lesion accumulation, and disability progression evolve along a linear temporal axis. However, converging pathological, imaging, biomarker,…
ObjectiveEpidermodysplasia verruciformis (EV) is a rare genodermatosis with susceptibility to specific HPVs and risk of malignant transformation. Atypical EV presenting as isolated facial hypopigmented macules closely mimicking pityriasis alba can lead…
BackgroundImmunotherapy has emerged as a promising strategy for pancreatic cancer. Radiotherapy not only mediates direct tumor cell killing but also provides a source of tumor antigens for dendritic cells (DCs) uptake and presentation via the induction…
BackgroundThe progression of heart failure (HF) following myocardial ischemia/reperfusion (I/R) injury is driven by regulated cell death. Unlike the restrained nature of apoptosis, pyroptosis and necroptosis are lytic processes that trigger inflammator…
Fusobacterium nucleatum (Fn) is recognized as a novel oncogenic organism closely correlated with colorectal cancer (CRC). Fn can induce gut dysbiosis and promote tumorigenesis through various mechanisms, including activation of oncogenic signaling, mod…
BackgroundSepsis-induced acute lung injury (ALI) represents the earliest and most severe complication of sepsis, with extraordinarily high mortality rates. Baihe Gujin decoction (BHGJD), a classical traditional Chinese medicine formula, has demonstrate…
Anti-IgLON5 disease is a rare autoimmune neurological disorder characterized by anti- neuronal surface autoantibodies targeting the Immunoglobulin-Like Cell Adhesion Molecule 5 (IgLON5) protein. We report a 53-year-old male patient diagnosed with anti-…
Diffuse cutaneous leishmaniasis (DCL), caused by Leishmania mexicana, is a chronic, treatment-refractory form of leishmaniasis characterized by multiple nodular lesions and high parasite load. During chronic infection, T cells acquire an exhausted immu…
IntroductionClostridium perfringens is the primary causative agent of enterotoxemia in yaks, resulting in substantial economic losses on the Qinghai-Tibet Plateau. Conventional vaccines exhibit limited protective breadth and suboptimal efficacy, highli…
Significant advancements have been made in kidney transplantation, with a wealth of immunosuppressive and antimicrobial therapies that have significantly improved graft survival. Despite these accomplishments, the ability to promptly identify kidney al…
ObjectiveWe hypothesized that preoperative administration of liposome arsenic trioxide (LATO) would downregulate hypoxia-inducible factor-1α (HIF-1α) in residual tumors following incomplete radiofrequency ablation (iRFA), thereby modulating the tumor m…
WHIM syndrome is a rare primary immunodeficiency disorder caused by gain-of-function mutations of the chemokine receptor CXCR4, leading to abnormal and exacerbated leukocyte trafficking. It is associated with severe neutropenia and lymphopenia, and rec…
BackgroundGranulomatosis with Polyangiitis (GPA) is an antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis that predominantly affects the upper or lower respiratory tracts and the kidney. While otologic involvement is relatively common in …
Urinary tract infections (UTIs) are common and traditionally linked to bacteria; however, yeasts— particularly Trichosporon asahii — have emerged as opportunistic pathogens in immunocompromised and hospitalized patients. The presence of fungi may repre…
ObjectiveThe pathogenesis of Long COVID (LC) remains poorly understood, with the analysis of immune responses often obscured by variables such as vaccination and reinfection. This study aimed to determine the primary immunological footprint of LC by ex…
BackgroundEarly diagnosis of sepsis remains a major clinical challenge due to the dynamic interplay between infection and host immune response. Conventional biomarkers often fail to capture the dynamic nature of immune activation. Neutrophil-derived re…
BackgroundCoagulation activation and tumor hemorrhage are common in colorectal cancer, but their combined immunological meaning remains incompletely defined. We developed a prespecified hemorrhage-coagulation immune phenotype (HCIP) integrating local h…
AimThis study aimed to compare the efficacy of postoperative adjuvant transcatheter arterial chemoembolization (PA-TACE) and adjuvant lenvatinib plus tislelizumab (PA-LT) in patients with Barcelona Clinic Liver Cancer (BCLC) stage 0–B hepatocellular ca…
IntroductionPeriodontitis prevalence is elevated in patients with inflammatory bowel diseases (IBD). Biological therapies targeting cytokines such as tumor necrosis factor (TNF) and interleukin-12/23 (IL-12/23) are central to IBD management, yet their …
Mucosal Immunol. 2026 Jun 27:100371. doi: 10.1016/j.mucimm.2026.100371. Online ahead of print. ABSTRACT Postbiotics offer improved safety and stability over live probiotics for modulating intestinal immunity, yet the receptor-mediated mechanisms underlying mucosal tolerance remain unclear. Nucleotide-binding oligomerization domain 2 (NOD2), a cytosolic sensor of bacterial cell wall components and a major genetic risk factor for inflammatory … Read more
Semin Immunol. 2026 Jun 27;83:102048. doi: 10.1016/j.smim.2026.102048. Online ahead of print. ABSTRACT Inflammation is a defining feature of the tumor microenvironment (TME) and a key driver of cancer progression. Among inflammatory mediators, the interleukin-1 (IL-1) family of cytokines serves as a central mediator linking tissue damage, metabolic stress and microbial cues to innate immune activation. … Read more
Curr Opin Immunol. 2026 Jun 27;101:102810. doi: 10.1016/j.coi.2026.102810. Online ahead of print. ABSTRACT Ocular sarcoidosis is a frequent manifestation of sarcoidosis and may occur most commonly affecting adults between 30 and 60 years old. Uveitis may be anterior, intermediate, posterior, or present as panuveitis, with marked heterogeneity in severity and clinical course. Diagnosis relies on … Read more
Curr Opin Immunol. 2026 Jun 27;101:102807. doi: 10.1016/j.coi.2026.102807. Online ahead of print. ABSTRACT In this review, we detail the features of barrier germinal centers (GC) that form in tertiary lymphoid structures (TLSs) within non-immune organs that host a local microbiome, and posit a framework of immunity where TLS-GCs created at barrier sites are a key … Read more
J Immunol. 2026 Jun 7;215(6):vkag151. doi: 10.1093/jimmun/vkag151. ABSTRACT Inflammatory diseases arise from complex interactions between immune signaling and cellular stress. Although endoplasmic reticulum (ER) stress is a key modulator of immunity, the mechanisms by which it promotes inflammatory pathology remain incompletely understood. Notably, ER stress-induced NF-κB activation alone is insufficient to account for robust IL-6 … Read more
J Leukoc Biol. 2026 Jun 27:qiag090. doi: 10.1093/jleuko/qiag090. Online ahead of print. ABSTRACT Macrophages coordinate cytokine responses by integrating signals from pattern recognition receptors including NOD2 and TLR4. NOD2 detects muramyl dipeptide derived from bacterial peptidoglycan, and TLR4 recognizes lipopolysaccharide in the outer membrane of Gram-negative bacteria. NOD2 and TLR4 signals synergize to enhance cytokine … Read more
J Leukoc Biol. 2026 Jun 27:qiag084. doi: 10.1093/jleuko/qiag084. Online ahead of print. ABSTRACT Originally characterized for its roles in T-cell activation and adhesion, CD43 is a prominent mucin-like sialoglycoprotein expressed on hematopoietic cells. CD43 is broadly expressed across leukocyte populations, with its levels, molecular configuration, and ligand interactions varying by cell type, activation state, and … Read more
Curr Opin Immunol. 2026 Jun 26;101:102808. doi: 10.1016/j.coi.2026.102808. Online ahead of print. ABSTRACT The SARS-CoV-2 pandemic has renewed interest in mucosal vaccines, yet these approaches have long struggled to generate durable protection against airway pathogens. A key limitation is the incomplete understanding of how upper airway antigens are handled to shape immune response quality and … Read more
J Immunol. 2026 Jun 7;215(6):vkag160. doi: 10.1093/jimmun/vkag160. ABSTRACT The V158F polymorphism found in the human Fc receptor CD16a (also known as FcγRIIIa) is thought to influence autoimmune disorders and responses to IgG-based therapies. V158F is known to influence the IgG affinity, and thereby triggering of the CD16a receptor expressed on various immune cells. In contrast … Read more
J Immunol. 2026 Jun 7;215(6):vkag168. doi: 10.1093/jimmun/vkag168. ABSTRACT Forkhead Box P1 (Foxp1) is a transcription factor critical for the proper development of multiple tissues. While Foxp1 has a well-described role in regulating adaptive immunity through modulation of T and B cells, a function in medullary thymic epithelial cells (mTECs) has not been reported. Here we … Read more
J Immunol. 2026 Jun 7;215(6):vkag170. doi: 10.1093/jimmun/vkag170. ABSTRACT Memory T-cell inflation is a distinctive immunological phenomenon observed during persistent viral infections such as cytomegalovirus (CMV). Unlike conventional memory T-cell responses, which contract after infection resolution, a subset of CMV-specific T cells undergoes a progressive and sustained expansion, termed “inflation”, which is thought to be critical … Read more
Cancer Immunol Res. 2026 Jun 26. doi: 10.1158/2326-6066.CIR-25-1611. Online ahead of print. ABSTRACT Immune checkpoint inhibitors (ICIs) have transformed cancer care, at times generating durable partial or even complete responses in advanced cancers. However, only a minority of patients experience these “excellent” responses. Thus, there is a need for novel biomarkers that can identify those … Read more
J Immunol. 2026 Jun 7;215(6):vkag143. doi: 10.1093/jimmun/vkag143. ABSTRACT Acquired immunity in mammals depends upon capture and presentation of antigens by specialized macrophage populations in splenic marginal zone and lymph node sinuses and follicular dendritic cells within germinal centers. Cells referred to as follicular dendritic cells in chickens express CSF1R, the receptor for CSF1 and IL34. … Read more
J Immunol. 2026 Jun 7;215(6):vkag133. doi: 10.1093/jimmun/vkag133. ABSTRACT Reproducible and efficient genetic engineering of human NK cells remains a primary challenge to next-generation chimeric antigen receptor (CAR) therapies, specifically for larger constructs with multiple plasmids and transgenes. Lentiviral vectors (LVs) pseudotyped with baboon envelope (BaEV) outperform vesicular stomatitis virus G protein in transducing hematopoietic stem … Read more
J Immunol. 2026 Jun 7;215(6):vkag137. doi: 10.1093/jimmun/vkag137. ABSTRACT In the canonical model of VDJ recombination, a single diversity (D) gene is incorporated into the complementarity-determining region 3 (CDR3) to produce a T cell receptor δ (TCRδ; TRD) or TCRβ (TRB) chain. But by constructing a dataset of more than 2.7 million TRD CDR3 sequences from … Read more
J Immunol. 2026 Jun 7;215(6):vkag135. doi: 10.1093/jimmun/vkag135. ABSTRACT Regulators of G protein signaling (RGS) deactivate G proteins associated with G protein-coupled receptors (GPCRs), a large receptor family with diverse functions. Of the 20 RGS, the Rgs14 single-nucleotide polymorphism is associated with inflammatory bowel disease, and Rgs14 expression is higher in macrophages than in epithelial cells. … Read more
