- The CXCL10/CXCR3 axis drives actin remodeling to recruit CD4+ T cells to gut epithelium during transmissible gastroenteritis virus infectionby inmunoadminJ Immunol. 2026 Aug 4;215(8):vkag222. doi: 10.1093/jimmun/vkag222. ABSTRACT The immune system initially protects hosts against viral pathogens, with chemokines guiding immune cell movement. However, their expression patterns and immune cell recruitment mechanisms during transmissible gastroenteritis virus (TGEV) infection are still not fully understood. Here, we identified a distinct chemokine expression profile in intestinal epithelial cells … Read more
- The IL-1 system in inflammation and cancer. Cecilia Garlandaby inmunoadminSemin Immunol. 2026 Aug 8;83:102051. doi: 10.1016/j.smim.2026.102051. Online ahead of print. ABSTRACT Inflammation is a pathogenetic driver of several pathological conditions, including cancer. The tumor microenvironment, which includes cellular, molecular, and structural components, is an essential component of cancer, involved in tumor promoting or controlling processes. In particular, inflammatory players contribute to the establishment of … Read more
- IgA binding characteristics of golden hamster and ferret Fcα receptorsby inmunoadminJ Immunol. 2026 Aug 4;215(8):vkag218. doi: 10.1093/jimmun/vkag218. ABSTRACT Golden hamster (Mesocricetus auratus) and ferret (Mustela putorius furo) are important animal models in studies of human infectious disease. They are used widely to investigate pathogen-spreading mechanisms and host immunology to evaluate the safety and efficacy of small molecules, biologic drugs and vaccines. To this end, immunoglobulin … Read more
- Delivery of extracellular vesicle-associated microRNA-146a regulates human monocyte phenotype and functionby inmunoadminJ Immunol. 2026 Aug 4;215(8):vkag226. doi: 10.1093/jimmun/vkag226. ABSTRACT CCR2+ monocytes are recruited to sites of acute myocardial injury, where they play a critical role in clearing necrotic debris and replenishing the depleted resident macrophage population. Although this response is necessary for early tissue repair, prolonged activation of inflammatory pathways and persistent recruitment of CCR2+ monocytes … Read more
- Identifying molecular signatures underpinning treatment responses to novel therapeutics influencing COVID-19 outcomesby inmunoadminJ Immunol. 2026 Aug 4;215(8):vkag189. doi: 10.1093/jimmun/vkag189. ABSTRACT COVID-19 continues to present ongoing global health challenges driven by diverse immune responses and heterogeneous clinical outcomes. The ACCORD trial evaluated 3 investigational treatments-bemcentinib, tozorakimab, and zilucoplan-in patients hospitalized with COVID-19, each of which has demonstrated clinical efficacy. To better understand their molecular mechanisms, we conducted a … Read more