- Mechanobiology of neutrophil inflammasome signaling in psoriasisby inmunoadminCurr Opin Immunol. 2025 Oct 17;97:102680. doi: 10.1016/j.coi.2025.102680. Online ahead of print. ABSTRACT While T cells play a prominent role, polymorphonuclear neutrophils (PMN) are also significant players in the pathogenesis of psoriasis. This review details the mechanobiology of PMN in the amplification of skin inflammation, a process often under-scrutinized compared to T cell pathways. PMN … Read more
- Immunoregulatory Functions of the ER Stress Sensor IRE1 in Myeloid Cell BiologyAlonso Lira on 18 de October de 2025 at 10:00by inmunoadminJ Leukoc Biol. 2025 Oct 17:qiaf145. doi: 10.1093/jleuko/qiaf145. Online ahead of print. ABSTRACT Myeloid cells- including monocytes, macrophages, dendritic cells (DCs), and granulocytes constitute a versatile arm of the immune system, serving as frontline sentinels that detect and react to environmental cues and orchestrate tailored immune responses. Their ability to respond promptly to distinct threats … Read more
- Short‐Chain Fatty Acid Sodium Butyrate Suppresses Protective Humoral Immunity by Inhibiting Follicular T Helper Cell Differentiation. [[{“value”:”Bhushan Nikam,
Someshwar Nath Jha,
Yatish Thakare,
Poonam Coshic,
Nimesh Gupta”}]]by inmunoadminWe show that sodium butyrate suppresses Tfh-cell differentiation, via HDAC inhibition, leading to inefficient germinal center responses and impaired antibody generation. This suboptimal humoral immunity fails to confer protection against virus infection, underscoring sodium butyrate’s potential impact on shaping GC-derived protective immunity. ABSTRACT The gut microbiome and its metabolites are critical regulators of intestinal homeostasis, … Read more
- T follicular helper cells drive functionally distinct lymphoid and lung resident germinal centres and limit allergic airway disease. Faith I Uwadiaeby inmunoadminMucosal Immunol. 2025 Oct 15:S1933-0219(25)00107-2. doi: 10.1016/j.mucimm.2025.10.005. Online ahead of print. ABSTRACT T follicular helper cells (TFH) play a central role in orchestrating antibody mediated immunity. Despite the importance of antibody responses, especially allergen-specific IgE, in allergic airway diseases (AAD) such as asthma, the precise role TFH play in AADs has remained elusive. Using a … Read more
- Three’s company: The cooperative signals behind the differentiation of Th9 cells. J Alejandra Rodriguezby inmunoadminSemin Immunol. 2025 Oct 16;80:101999. doi: 10.1016/j.smim.2025.101999. Online ahead of print. ABSTRACT T helper 9 (Th9) cells, characterized by their production of interleukin-9 (IL-9), play pivotal roles in protective immunity and inflammatory disease. Their differentiation depends on the integration of three signals: TCR engagement (Signal 1), co-stimulatory receptor activation (Signal 2), and cytokine-driven transcriptional programming … Read more