- Elevated CHAF1A suppresses type I interferon production and causes immunotherapy resistance in esophageal squamous cell carcinomaby inmunoadminCancer Immunol Res. 2026 Jul 16. doi: 10.1158/2326-6066.CIR-25-1617. Online ahead of print. ABSTRACT In esophageal squamous cell carcinoma (ESCC), chemoradiotherapy potentiates the effects of immune checkpoint inhibitors (ICIs) by activating the tumor-intrinsic innate immune response. However, ESCC cells frequently suppress this activation, which contributes to the high rates of immunotherapy resistance (70-80%) observed clinically. Thus, … Read more
- CD4+ T cells play distinct roles during the priming versus effector phases of immune checkpoint therapy-dependent tumor elimination by CD8+ T cellsby inmunoadminCancer Immunol Res. 2026 Jul 16. doi: 10.1158/2326-6066.CIR-25-1652. Online ahead of print. ABSTRACT It is well established that CD4⁺ T cells play a critical role in facilitating immune checkpoint therapy (ICT). Although CD4+ T-cell function in lymph nodes during CD8⁺ T-cell priming has been well investigated, their requirement at the effector phase in the tumor … Read more
- Lysosome-Induced Increase in Intracellular Granularity of Leukocytes: A Key Morphological Biomarker for Early Sepsis in Cell Population DataHuan Qi on 16 de July de 2026 at 10:00by inmunoadminJ Leukoc Biol. 2026 Jul 16:qiag098. doi: 10.1093/jleuko/qiag098. Online ahead of print. ABSTRACT Early and rapid identification of sepsis is critical for improving clinical outcomes; however, reliable real-time biomarkers remain unavailable. The scattergram parameters of peripheral blood circulating leukocytes are altered during infection and sepsis. This study aims to explore the cellular biological characteristics underlying … Read more
- A role for non-coding RNAs and alternative splicing in the regulation of neutrophil activation and gene expression in systemic lupus erythematosusGrace Filbertine on 16 de July de 2026 at 10:00by inmunoadminJ Leukoc Biol. 2026 Jul 16:qiag100. doi: 10.1093/jleuko/qiag100. Online ahead of print. ABSTRACT Excess neutrophil apoptosis and the release of neutrophil extracellular traps (NETs) in systemic lupus erythematosus (SLE) leads to accumulation of cell debris and production of auto-antibodies targeting nuclear proteins and DNA. SLE neutrophil activation is regulated by changes in gene expression, notably … Read more
- Blautia coccoides-derived acetate potentiates anti-PD-1 immunotherapy in melanoma by activating cytotoxic CD8+ T cellsby Zhang, Z., Liang, X., Tian, Y., Li, C., Cao, X., Wang, D., Xie, A., Liu, S., Lin, K., Li, Q., Liang, Y.Background Gut microbiota can modulate cancer immunotherapy and enhance the efficacy of programmed cell death protein 1 (PD-1) blockade in tumors, yet the responsible microbes and underlying mechanisms remain incompletely understood. Methods Publicly…