A molecule opens a breach in HIV, providing access to its reservoirs
An international team led by two Université de Montréal researchers has unveiled how a molecule capable of opening the “shell” of HIV improves the elimination of infected cells.
HIV & AIDS
Fighting two infections at once: Hepatitis C cure may relieve immune strain in HIV patients
The hepatitis C virus—HCV—can persist in the livers of those infected and even lead to liver disease or failure in extreme cases. It affects tens of millions of people worldwide and there is no vaccine to prevent infection, but effective treatment can …
New study identifies key mechanism driving HIV-associated immune suppression
Researchers from the Institute of Human Virology (IHV) at the University of Maryland School of Medicine have discovered how a specific type of immune cell may contribute to the persistence of HIV infections. The finding offers new insight into why the …
Self-reactive T cells may explain why some patients can’t reach undetectable HIV levels
Despite the capability of antiretroviral drugs to suppress HIV to undetectable levels, some people living with the human immunodeficiency virus can’t reach the goal of viral imperceptibility even with daily doses of the potent medications.
Early HIV drugs give immune system a brief reprieve before dysregulation returns, study finds
Despite effective HIV medication, the immune system of people with HIV remains disrupted in the long term.
Perineural pathway that fuels HIV persistence despite treatment identified
Addressing the question of whether and how immune cells (macrophages) in the central nervous system (CNS) traffic out, researchers have now identified a perineural pathway through which the HIV virus can redistribute throughout the body. The findings f…
Immunotherapy approach offers hope for long-term HIV control without daily medication
HIV remains a major global health issue, affecting nearly 40 million people worldwide. Current treatments, known as antiretroviral therapy (ART), are highly effective at suppressing the virus and preventing illness, but they are not curative and must b…
Antibody discovered that blocks almost all known HIV variants in neutralization assays
An international research team led by the University of Cologne has discovered an antibody that could advance the fight against HIV. The newly identified antibody 04_A06 proved to be particularly effective in laboratory tests. It was able to neutralize…
Findings on a toxic HIV molecule pave way for clinical drug trial
What if the presence of a well-known but misunderstood viral protein explains why some people living with HIV (PLWH) never recover their health, even with antiretroviral treatment?
HIV mystery uncovered: How the virus reprograms host cells to create perfect hiding places
For over three decades, HIV has played an elaborate game of hide-and-seek with researchers, making treating—and possibly even curing—the disease a seemingly insurmountable obstacle to achieve.