New gene discovery aids HIV vaccine progress
Continuing their journey to develop a vaccine for HIV, Oregon Health & Science University researchers have identified a gene that could have prevented their vaccine from working in humans.
HIV & AIDS
Multiomics of HIV non-progressors reveals immunity behind AIDS evasion
A multiomic analysis led by the IrsiCaixa AIDS Research Institute has uncovered genetic and immune mechanisms in some HIV-positive individuals, known as viremic non-progressors (VNPs), to avoid disease progression without antiretroviral therapy.
‘Undetectable’ HIV patients could hold key to treatments
A rare group of HIV-positive people who maintain undetectable levels of the virus in their blood without medication could hold the key to new therapies for others living with the disease, says a leading genome expert.
Team demonstrates unprecedented control of SIV replication with immune-based approach
Emory researchers are the first to show unprecedented control of SIV replication and decay of viral reservoirs by combining a stringent model of infection with the interruption of antiretroviral therapy (ART). The success of this immune-based approach …
Triple antibody therapy shows promise for long-lasting HIV control
In a study of 12 participants, researchers at Beth Israel Deaconess Medical Center (BIDMC) have demonstrated that a cocktail of three broadly neutralizing antibodies (bNAb) successfully suppressed virus in people living with HIV. A subset of participan…
Diabetes drug helps the immune system recognize reservoirs of HIV, study discovers
Metformin, a drug used to treat type 2 diabetes, could help deplete the viral reservoir and eliminate it entirely in people living with HIV who receive antiretroviral therapy, Canadian researchers say in a new study.
Study: First sustained remission of HIV infection following a bone marrow transplant in absence of protective mutation
A total of seven individuals worldwide (two patients in Berlin and patients in London, Düsseldorf, New York, City of Hope and Geneva) are considered likely to have been cured or to be in long-term remission of HIV infection after receiving a bone marro…
New lab test to detect persistent HIV strains in Africa may aid search for cure
A multinational team led by Weill Cornell Medicine investigators developed a test that will help measure the persistence of HIV in people affected by viral strains found predominantly in Africa—a vital tool in the search for an HIV cure that will benef…
Study highlights need for cell-type-specific therapies in treatment of HIV
Researchers from the University of Illinois have demonstrated the importance of cell-type-specific targeting in the treatment of HIV. Their study, published in the Proceedings of the National Academy of Sciences, is one of the first to examine the diff…
Study highlights importance of early interventions to combat HIV
A study has compared the development of HIV reservoirs—locations in the body where the virus persists in a latent state—between patients who receive either early or late medical interventions. The findings highlight the importance of timely treatments …