Study provides a blueprint of tumor-infiltrating B cells with therapeutic implications
In a study published in Science on May 3, researchers unveiled two responding patterns of tumor-infiltrating B cells with therapeutic implications.
Medical Xpress
Researchers find B cells drive responses of other immune cells, can be modified to prevent multiple sclerosis symptoms
B cells can control responses of myeloid cells through the release of particular cytokines (small proteins that control the growth and activity of cells in the immune system), disproving the previous consensus that T cells are the only orchestrators of…
New approach for developing cancer vaccines could make immunotherapies more effective in acute myeloid leukemia
Acute myeloid leukemia (AML) is a type of blood cancer that forms in the soft marrow of the bones, typically attacking cells that would otherwise form the key component of the body’s immunodefense system, white blood cells.
Drug targeting RNA modifications shows promise for treating neuroblastoma
Neuroblastoma is a common pediatric cancer that originates in developing nerve cells outside the brain. While increasingly intensive treatments have improved the survival of patients with high-risk neuroblastoma, currently more than 40% of patients do …
Newly discovered mechanism of T-cell control can interfere with cancer immunotherapies
Activated T cells that carry a certain marker protein on their surface are controlled by natural killer (NK) cells, another cell type of the immune system. In this way, the body presumably curbs destructive immune reactions.
Scientists discover new immunosuppressive mechanism in brain cancer
The Wistar Institute assistant professor Filippo Veglia, Ph.D., and team, have discovered a key mechanism of how glioblastoma—a serious and often fatal brain cancer—suppresses the immune system so that the tumor can grow unimpeded by the body’s defense…
Pan-cancer analysis uncovers a new class of promising CAR T–cell immunotherapy targets
Targeting anti-cancer therapy to affect cancer cells but not healthy cells is challenging. For chimeric antigen receptor (CAR) T–cell immunotherapy, where a patient’s own immune cells are re-engineered to attack cancer cells, many solid and brain cance…
Lymphocytes recruit the immune system to fight most aggressive breast cancer, study confirms
Researchers at the UAB and the Hospital del Mar Research Institute have confirmed that patients with the presence of NK lymphocytes around tumors have a better response to treatment. This confirms the feasibility of using cytokines secreted by NK cells…
Molecular testing: Pioneering precision medicine for colorectal cancer
A new perspective paper explores the current state and future directions of precision medicine in colorectal cancer (CRC). It outlines advancements in molecular testing and their implications for targeted and immunological therapies in CRC. This resear…
Researchers discover how immune B cells hunt down cancer around the body
Scientists have discovered the key features of immune B cells that make them successful at targeting tumors—including when cancer has spread to a different part of the body.