An international team of researchers report in the journal Nature Immunology that a mutation in the gene OTULIN causes pediatric-onset pyoderma gangrenosum, characterized by recurrent ulcerating skin sores. They classify the condition as a new inborn e…
Researchers at the University of Maryland School of Medicine (UMSOM) have identified a target that may improve the response to CAR T-cell therapy, a treatment for patients with recurrent or difficult-to-treat blood cancers.
A detailed cellular study of Crohn’s disease has mapped how gene activity changes across more than 50 cell types in the gut. The study provides an open resource of the genes that characterize each cell type and those whose activity shifts in disease, u…
Dual-target CAR T-cell therapy for recurrent glioblastoma (GBM), delivered directly into the cerebrospinal fluid (CSF), triggers a broad immune response, with natural killer (NK) cell activation linked to better patient outcomes and longer overall surv…
Certain white blood cells in the immune system, known as neutrophils, can make cancer immunotherapy less effective, according to a new study from Karolinska Institutet published in the journal Immunity. The results show that a signaling molecule in the…
Researchers from Amsterdam UMC, in collaboration with other hospitals, have successfully completed the first Phase III study of an in vivo CRISPR therapy. In this large-scale, double-blind trial, 80 patients with hereditary angioedema were randomized t…
You might think of cancer as a mass of rogue cells that grow uncontrollably. But cancer is more organized and strategic than that. Rather, cancer is a tightly controlled cellular neighborhood that can keep the body’s defenses out or weaken them once th…
It’s common knowledge that ticks can spread infections that cause serious illnesses, including Lyme disease. Now health officials are trying to raise awareness of a lesser-known problem: a life-threatening allergy to meat triggered by tick bites.
Scientists at Florida International University may have found a way to make a powerful cancer treatment work even better. The treatment, called CAR-T therapy, uses a patient’s own immune cells to fight cancer. Doctors remove special immune cells called…
Patients with COVID-19 can show several different antiviral immune response patterns, which may influence how the disease develops. This is shown in a new study from Karolinska Institutet, published in Genome Medicine, highlighting the importance of in…
