A new Northwestern Medicine study has uncovered how a key immunoregulatory receptor plays an unexpected dual role in promoting T-cell exhaustion during chronic infection and cancer, according to findings published in the Proceedings of the National Aca…
Researchers at the Icahn School of Medicine at Mount Sinai have identified the immune cell that acts as the architect and coordinator of powerful immune hubs that form inside tumors and plays a key role in antitumor immunity. This discovery could lead …
We may age at different rates, but none of us escapes aging. A study in mice and human cells by Stanford Medicine researchers pins much of the blame on a particular type of immune cell’s increasing inability, with advancing age, to gobble up another im…
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer that is often diagnosed at advanced stages and carries a low five-year survival rate. Approximately 10% of cases are associated with hereditary predisposition caused by pathogenic mutation…
New research from The Kids Research Institute Australia suggests a simple dietary intervention during pregnancy could help protect against the increased risk of food allergies associated with antibiotics taken before birth.
A subset of cancers, known as microsatellite instability (MSI) and deficient DNA mismatch repair (dMMR) cancers, are more visible to the immune system than others. Because their DNA repair systems are defective, these tumors are more likely to be recog…
Researchers at The University of Texas MD Anderson Cancer Center have discovered a new way in which T cells attack acute myeloid leukemia (AML) cells, which may help explain why AML is particularly sensitive to immune-based treatments and could guide t…
Birds possess a specialized organ called the bursa of Fabricius that mammals do not have. It has long been thought that B cells, part of the immune system, develop exclusively in this organ. However, researchers from Tohoku University have discovered a…
Dozens of research teams around the world are working to halt, treat and even prevent Alzheimer’s disease, which silently develops in the brain for more than a decade before symptoms appear. Although recent years have brought important advances, resear…
Humans cannot fully heal spinal cord injuries. When the spinal cord is damaged, the body’s immune system often spirals into chaos. This overwhelming inflammatory response creates permanent scar tissue that stops nerve cells from ever repairing themselv…
