Using targeted radiation during surgery—referred to as intraoperative radiation—to eliminate pancreatic cancer cells that have spread to areas around the pancreas, investigators at Johns Hopkins have been able to reduce the recurrence rate around the p…
In a new study, University of Arizona researchers created a model for cutaneous squamous cell carcinoma, a type of skin cancer, and identified two mutated tumor proteins, or neoantigens, that contain features of good candidates for a vaccine.
Cancer immunotherapy, especially using T cells, is showing a lot of promise in treating blood cancers. Bioengineered T cells, especially those equipped with chimeric antigen receptors (CAR-T cells), have revolutionized cancer treatment. But while they’…
Melanoma is the most common form of skin cancer, but for patients with advanced melanoma who no longer respond to standard immunotherapy, treatment options are painfully limited. Vanderbilt researchers led by Professor Emerita of Pharmacology Ann Richm…
A team of researchers led by Peter Mac’s Professor Sherene Loi has uncovered how having children and breastfeeding reduces a woman’s long-term risk of breast cancer.
An international collaboration of researchers, including Imperial College London and UCLA, has developed a collagen-binding interleukin 12 strategy that lets CAR-T cells treat prostate cancer in mice while curbing previously encountered cytokine-relate…
Promising study in dual inhibition of PD1 and macrophage migration inhibitory factor
Results of a study led by researchers at Roswell Park Comprehensive Cancer Center show that combining two types of immunotherapy—engineered T cells that secrete bispecific T cell engagers (BiTEs) and an immune checkpoint inhibitor—can alter the tumor m…
A research team led by the Faculty of Dentistry at The University of Hong Kong (HKU) has developed a novel vascularized tumor model using a non-surgical injectable hydrogel system. This innovative approach provides a powerful new platform for researchi…
A research team has discovered a previously overlooked subtype of brain tumor termed IME IDH-mutant astrocytoma. Contrary to typical medical expectations, this subtype exhibits strong immune activity, classified as “immune‑hot,” yet tends to have poore…
