A new form of tumor infiltrating lymphocyte (TIL) therapy, a form of personalized cancer immunotherapy, dramatically improved the treatment’s effectiveness in patients with metastatic gastrointestinal cancers, according to results of a clinical trial l…
When your social media account starts spewing out nonsensical or threatening status updates, it’s safe to assume that it has been hacked and must be shut down.
During development, cells grow, expand, and migrate to generate tissues and organs in a highly controlled manner. Many intracellular pathways—series of signaling cascades within a cell—regulate these actions to avoid non-programmed growth that could le…
Cutaneous melanoma, the most aggressive form of skin cancer, is characterized by its accumulation of a large number of mutations. Although some of these alterations should be recognized as a threat by our defenses, melanomas often escape immune system …
A new study published in the journal Immunity reveals a mechanism that allows triple negative breast cancer (TNBC) to develop resistance to therapy.
Triple-negative breast cancer, an aggressive type of breast cancer, accounts for 10% of all breast cancer cases in the United States annually. CD8+ T cells that normally kill cancer cells often become exhausted and stop.
Glioblastoma, one of the most aggressive and lethal brain cancers, has a five-year survival rate of only 6.9%, according to the National Brain Tumor Society. While the relationship between glioblastoma and cell death, also called necrosis, has been est…
Yale scientists have discovered a promising way to trigger immune responses against certain tumors, using a lupus-related antibody that can slip, undetected, into “cold” tumors and flip on an immune response that has been turned off by cancer. The rese…
Among other functions, the NK cells (natural killers, a type of lymphocyte forming part of the immune system) have the capacity to detect and eliminate cancer cells. But in some cases they cannot overcome the tumor’s defense mechanism and the cancer gr…
B-cell acute lymphoblastic leukemia (B-ALL) is a life-threatening and highly aggressive form of blood cancer. It is the most common childhood cancer, making up 35% of pediatric cancer cases, but it can affect people of any age. CAR T-cell therapy has s…
