Researchers enhance natural killer cells to target pediatric brain cancer
Florida State University researchers are giving oncologists another tool in their fight against pediatric brain cancer.
Oncology & Cancer
Natural killer cells expressing interleukin-21 show promising antitumor activity in glioblastoma cells
Natural killer (NK) cells engineered to express interleukin-21 (IL-21) demonstrated sustained antitumor activity against glioblastoma stem cell-like cells (GSCs) both in vitro and in vivo, according to new research from The University of Texas MD Ander…
Light-activated macrophages show increased appetite for cancer cells
The body has a veritable army constantly on guard to keep us safe from microscopic threats from infections to cancer. Chief among these forces is the macrophage, a white blood cell that surveils tissues and consumes pathogens, debris, dead cells, and c…
Unmasking hidden potential: LMO4 enhances T cell cancer-fighting abilities
T cell therapies, which use genetically-engineered T cells of the human immune system as therapeutics, are revolutionizing medical oncology by effectively treating previously incurable blood cancers. However, their success against solid tumors has been…
Tpex cells: A game-changer in targeted tumor immunotherapy
Progenitor exhausted CD8+ T (Tpex) cells have emerged as a pivotal component in tumor immunotherapy due to their unique ability to self-renew and rapidly proliferate. These cells have shown promise in expanding and differentiating into functional exhau…
Individualized cancer therapy demonstrates safety and sustained immune responses in Phase I trial
For decades, researchers have worked to develop therapies that can prime the immune system to recognize and attack proteins on the surface of tumor cells. However, success has been limited due to the technological challenge of engineering therapies tha…
Study shows a distinct pattern in protein production can predict severe side effects from skin cancer treatment
An activity pattern in certain genes responsible for building proteins known as spleen tyrosine kinases can predict which melanoma patients are likely to have severe side effects from immunotherapy designed to treat the most deadly skin cancer, a study…
Researchers develop pioneering immunotherapy for aggressive brain cancer
QIMR Berghofer researchers have developed super-charged immune cells that could potentially improve glioblastoma survival by fighting the deadly brain cancer and preventing its recurrence.
Scientists unravel how the BCG vaccine leads to the destruction of bladder cancer cells
Using zebrafish “avatars,” an animal model developed by the Cancer Development and Innate Immune Evasion lab at the Champalimaud Foundation (CF), led by Rita Fior, Mayra Martínez-López—a former Ph.D. student at the lab now working at the Universidad de…
Cancer stem cell-immune cell crosstalk in the tumor microenvironment for liver cancer progression
The complex dynamics between liver cancer stem cells (CSCs) and immune cells within the tumor microenvironment (TME) are central to the progression of liver cancer. These interactions are critical in creating an immunosuppressive setting that significa…