Review explores potential of senescent cell-derived vaccines for cancer and aging
A new review paper titled “Senescent cell-derived vaccines: a new concept towards an immune response against cancer and aging?” has been published in Aging.
Oncology & Cancer
The current state of immunotherapy in colorectal cancer
Colorectal cancer (CRC) is a major health concern worldwide, characterized by high incidence and mortality rates. Despite advances in treatment, metastatic CRC (mCRC) remains particularly challenging.
New therapy strengthens the immune system’s counterattack on skin cancer
An international research team has demonstrated a method to identify the cells in the immune system that can recognize and fight cancer cells in samples from 9 out of 10 patients affected by the rare but aggressive form of skin cancer, Merkel cell carc…
New antibody harbors great potential for fighting blood cancer
Acute lymphoblastic leukemia (ALL) is the most common cancer in children. This form of blood cancer, which also occurs in adults, is caused by malignantly degenerated precursor cells of certain white blood cells (B-cell precursors or T-cells) that divi…
Breakthrough research makes cancer-fighting viral agent more effective
When a cancer cell doesn’t respond to traditional therapies, doctors may turn to a sort of viral biological warfare, by deploying “troops” in the form of viral agents that are specifically engineered to target and eliminate cancer cells. The mode of at…
Study suggests changing the gut microbiome improves health outcomes for newly-diagnosed metastatic kidney cancer
Physician scientists from City of Hope, one of the largest cancer research and treatment organizations in the United States, found that people with metastatic kidney cancer who orally took a live biotherapeutic product called CBM588 while in treatment …
Understanding the mechanism behind melanoma resistance to treatment
In many cases of malignant melanoma, the effect of targeted treatment is lost over time. A research team from UZH and USZ has now discovered that a factor secreted by tumor cells is responsible for the resistance. These findings could pave the way for …
Starving cancer cells to enhance DNA damage and immunotherapy response
A new research perspective titled “Starving cancer cells to enhance DNA damage and immunotherapy response” has been published in Oncotarget.
Slowing inflammation may boost immunotherapy’s effectiveness against advanced lung cancer
Adding an anti-inflammatory drug to anti-PD1 checkpoint inhibitor immunotherapy has shown great promise as a new strategy against advanced lung cancer, based on results from a small clinical trial led by investigators at the Abramson Family Cancer Cent…
Team finds exportin 1 governs immunosuppressive functions of myeloid-derived suppressor cells in tumors
A team of Roswell Park Comprehensive Cancer Center experts led by Hemn Mohammadpour, DVM, Ph.D., has conducted research that offers new insights into tumor biology and may lay the groundwork for more effective cancer immunotherapy.