- The indole-brain connection: neuroimmune mechanisms and therapyby inmunoadminCurr Opin Immunol. 2025 Dec 11;98:102708. doi: 10.1016/j.coi.2025.102708. Online ahead of print. ABSTRACT The microbiota-gut-brain axis (MGBA) has been recognized as an important communication network between the gut and the brain. This network operates through immune, neural, and endocrine pathways, wherein microbiota-derived metabolites act as essential messengers regulating MGBA. Among gut metabolites, indole and its … Read more
- Salivary gland organoids and the future of modeling autoimmune epithelitis in Sjögren’s diseaseby inmunoadminCurr Opin Immunol. 2025 Dec 11;98:102707. doi: 10.1016/j.coi.2025.102707. Online ahead of print. ABSTRACT Sjögren’s disease (SjD) is a systemic autoimmune disorder characterized by a striking tropism for epithelial tissues, particularly the salivary and lacrimal glands. Lack of function of the salivary glands (SGs) leads to a panoply of symptoms, dramatically reducing patient quality of life. … Read more
- Tissue signatures of human macrophages during homeostasis and activationby inmunoadminJ Immunol. 2025 Dec 12:vkaf317. doi: 10.1093/jimmun/vkaf317. Online ahead of print. ABSTRACT Human macrophages (MΦs) reside in tissues and develop tissue-specific identities. While studies in mice have identified molecular signatures for site-specific MΦ differentiation, less is known about the transcriptional profiles of human MΦs in distinct sites, including mucosal tissues and lymphoid organs during homeostasis … Read more
- Maternal proteome profiling reveals dynamic gestational age-specific responses to de novo vaccinationby inmunoadminJ Immunol. 2025 Dec 12:vkaf298. doi: 10.1093/jimmun/vkaf298. Online ahead of print. ABSTRACT Pregnancy is characterized by dynamic immunological adaptations which are essential for maintaining both maternal and fetal health. The first-time use of coronavirus disease 2019 (COVID-19) vaccines in pregnant individuals presented an opportunity to discover pregnancy-specific immunoproteomic signatures across gestation. In this study, we … Read more
- Sex-Specific Metabolic Programming in Human Neutrophil SubsetsAnjali S Yennemadi on 12 de December de 2025 at 11:00by inmunoadminJ Leukoc Biol. 2025 Dec 12:qiaf179. doi: 10.1093/jleuko/qiaf179. Online ahead of print. ABSTRACT While sex differences in neutrophil metabolism have been documented, whether this metabolic dimorphism extends to specific neutrophil subsets remains unknown.LDNs are characterized by their lower buoyant density compared to normal-density neutrophils(NDNs), are present in low numbers in healthy individuals, and are often … Read more