- Countering tumor-derived PGE2-EP2/4 signaling mediates neutrophil activationJohanna Bödder on 28 de January de 2026 at 11:00by inmunoadminJ Leukoc Biol. 2025 Dec 26;118(1):qiaf186. doi: 10.1093/jleuko/qiaf186. ABSTRACT Neutrophils have recently been demonstrated to play a variable role in cancer progression, likely due to adaptability to environmental signals that influence neutrophil phenotype and function. In the tumor microenvironment, tumor-derived prostaglandin E2 is well established as a major suppressor of immune cell function and facilitates … Read more
- EpCAM (CD326) is dispensable for in vitro B cell activation and maintenance of antibody-secreting cellsShannon R Menzel on 28 de January de 2026 at 11:00by inmunoadminJ Leukoc Biol. 2025 Dec 26;118(1):qiaf162. doi: 10.1093/jleuko/qiaf162. ABSTRACT Antibody-secreting cells (ASCs) provide the foundation for protective humoral immunity following infection or vaccination. Recent advances have revealed substantial phenotypic complexity within the ASC compartment, associated with diverse functional states and differentiation stages. Epithelial cell adhesion molecule (EpCAM, CD326) has emerged as a marker of mature … Read more
- Type I interferonopathy in ATR-X syndrome reveals a transcriptional role for cGASby Rachel GeltmanNature Reviews Immunology, Published online: 28 January 2026; doi:10.1038/s41577-026-01275-5A preprint by El-Daher et al. describes an interferonopathy-associated mutation in the chromatin remodeller ATRX, which identifies an unexpecte…
- Roles of T cell subpopulations in thyroid eye disease. Hemlata Bisnauthsing Kelvin K.L. Chong Clement C. Tham Chi Pui Pang Wai Kit Chu a Department of Ophthalmology & Visual Sciences, The Chinese University of Hong Kong, Hong Kong SAR, Chinaby inmunoadminVolume 59, Issue 1, December 2026.
- Significance of glomerular IgG3 deposition in patients with primary membranous nephropathy. Ming-Xuan Gao Zhen-Jun Zhao Hong-Shan Chen Jia-Yi Ma Xi Cheng Yan Qi Xin Cao Xi-Qian Gao Ying-Xin Fang Li Wei Wen-Ya Shang Jun-Ya Jia Tie-Kun Yan Peng-Cheng Xu Qiu-Hua Gu a Department of Nephrology, Kidney Disease Medical Center, Tianjin Medical University General Hospital, National Key Clinical Specialty, Tianjin Key Medical Discipline, Tianjin, People’s Republic of Chinab Department of Nephrology, Tianjin Medical University General Hospital Airport Hospital, Tianjin, People’s Republic of Chinaby inmunoadminVolume 59, Issue 1, December 2026.