Mucosa Immunology

Mucosal Immunol. 2025 Apr 1:S1933-0219(25)00032-7. doi: 10.1016/j.mucimm.2025.03.006. Online ahead of print. ABSTRACT Intranasal vaccines potentially offer superior protection against viral infections compared with injectable vaccines. The immunogenicity of intranasal vaccines including adenovirus vector (AdV), has room for improvement, while few options are available for safe execution. In this study, we demonstrate that modifying a basic … Read more

Mucosal Immunol. 2025 Mar 29:S1933-0219(25)00033-9. doi: 10.1016/j.mucimm.2025.03.007. Online ahead of print. ABSTRACT Alterations in goblet cell biology constitute one of the most effective host responses against enteric parasites. In the gastrointestinal (GI) tract, millions of bacteria influence these goblet cell responses by binding to pattern recognition receptors such as toll-like receptors (TLRs). Studies suggest that … Read more

Mucosal Immunol. 2025 Mar 28:S1933-0219(25)00030-3. doi: 10.1016/j.mucimm.2025.03.004. Online ahead of print. ABSTRACT Adult skin varies across regions, with differences in chemical, physical, microbiota, and immune barriers. However, data on topographical immune differences in other age groups are limited. This study aimed to explore the chronological maturation of the immune barrier in various skin regions. A … Read more

Mucosal Immunol. 2025 Mar 28:S1933-0219(25)00031-5. doi: 10.1016/j.mucimm.2025.03.005. Online ahead of print. ABSTRACT Heatstroke (HS) is typically considered a sepsis-like syndrome caused by hyperthermia, often accompanied by multiple organ dysfunctions (MODS). To explore the mechanisms of MODS, we established a mouse model of HS by exposing mice to a hyperthermic and high-humidity environment. Then, we utilized … Read more

Mucosal Immunol. 2025 Mar 26:S1933-0219(25)00029-7. doi: 10.1016/j.mucimm.2025.03.003. Online ahead of print. ABSTRACT Our understanding of the airway epithelium’s role in driving asthma pathogenesis has evolved over time. From being regarded primarily as a physical barrier that could be damaged via inflammation, the epithelium is now known to actively contribute to asthma development through interactions with … Read more

Mucosal Immunol. 2025 Mar 17:S1933-0219(25)00027-3. doi: 10.1016/j.mucimm.2025.03.001. Online ahead of print. ABSTRACT Pseudomonas aeruginosa (P.aeruginosa) is a pathogenic opportunistic bacterium, classified as a priority by the WHO for the research of new treatments. As this bacterium is harmful through the inflammation and tissue damage it causes, we investigated the role of Myeloid Derived Suppressor Cells … Read more

Mucosal Immunol. 2025 Mar 14:S1933-0219(25)00028-5. doi: 10.1016/j.mucimm.2025.03.002. Online ahead of print. ABSTRACT Host-microbiota cooperation is critical for successful intestinal homeostasis. The commensal segmented filamentous bacteria (SFB) are crucial for orchestrating the post-natal maturation of the host gut immune system and establishing a healthy state of physiological inflammation, which largely depends on their intimate attachment to … Read more

Mucosal Immunol. 2025 Mar 6:S1933-0219(25)00026-1. doi: 10.1016/j.mucimm.2025.02.008. Online ahead of print. ABSTRACT Inflammatory Bowel Disease (IBD) features en masse neutrophil (PMN) infiltration of the colon tissue, where PMNs occupy spatially distinct niches, including the lamina propria mucosa (LPNs) and the crypt epithelium (epithelium-associated neutrophils or EANs). Spatial PMN localization is currently used as a clinical … Read more

Mucosal Immunol. 2025 Feb 26:S1933-0219(25)00024-8. doi: 10.1016/j.mucimm.2025.02.006. Online ahead of print. ABSTRACT Females are disproportionately affected by asthma. An increased understanding of how female sex hormones influence key pathophysiological processes that underpin asthma may identify new, more effective asthma therapies, particularly for females with severe, poorly controlled asthma. We assessed the effects of oral ethinylestradiol/levonorgestrel … Read more

Mucosal Immunol. 2025 Feb 25:S1933-0219(25)00025-X. doi: 10.1016/j.mucimm.2025.02.007. Online ahead of print. ABSTRACT Autoimmune uveitis (AIU) is an immune-inflammatory disease that can lead to blindness. However, incomplete understanding of the involved immune cell subsets and their contributions to retinal injury has hindered the development of effective AIU therapies. Using single-cell RNA sequencing and immunofluorescence, we identified … Read more

Mucosal Immunol. 2025 Feb 21:S1933-0219(25)00021-2. doi: 10.1016/j.mucimm.2025.02.003. Online ahead of print. ABSTRACT Emerging evidence indicates that gingival-resident helper CD4+ T cells are major drivers of periodontal inflammation in response to commensal and pathogenic oral microorganisms. Whether tissue-resident memory CD8+ T cells (TRM), which principally safeguard against viruses and cancer but also drive certain autoimmune and … Read more

Mucosal Immunol. 2025 Feb 21:S1933-0219(25)00023-6. doi: 10.1016/j.mucimm.2025.02.005. Online ahead of print. ABSTRACT Interleukin-10 (IL-10) is an immunomodulatory cytokine critical for intestinal immune homeostasis. IL-10 is produced by various immune cells but IL-10 receptor signaling in intestinal CX3CR1+ mononuclear phagocytes is necessary to prevent spontaneous colitis in mice. Here, we utilized fluorescent protein reporters and cell-specific … Read more

Mucosal Immunol. 2025 Feb 19:S1933-0219(25)00022-4. doi: 10.1016/j.mucimm.2025.02.004. Online ahead of print. ABSTRACT Lung-resident memory T cells (lung TRMs) settle in the lung and respond rapidly to external antigens, and are therefore considered to have great potential for development of respiratory vaccines. Here, we demonstrate that lung-resident memory Th2 cells (lung TRM2) protect against pulmonary mycosis … Read more

Mucosal Immunol. 2025 Feb 19:S1933-0219(25)00020-0. doi: 10.1016/j.mucimm.2025.02.002. Online ahead of print. ABSTRACT Recently, we demonstrated that influenza A virus (IAV)-infected murine neonates lacking a functional IFN-I receptor (IFNAR-/-) had significantly improved survival and reduced lung pathology relative to wild-type (WT) neonates. In direct contrast, adult IFNAR-/- mice display enhanced morbidity following IAV infection relative to … Read more

Mucosal Immunol. 2025 Feb 18:S1933-0219(25)00019-4. doi: 10.1016/j.mucimm.2025.02.001. Online ahead of print. ABSTRACT Influenza virus infection is a leading cause of morbidity and mortality worldwide, posing a significant public health problem. The pro-inflammatory cytokine interleukin-6 (IL-6) has been shown to promote defense against respiratory viral infection, while excessive IL-6 responses have been associated with severe pneumonia. … Read more

Mucosal Immunol. 2025 Feb 5:S1933-0219(25)00010-8. doi: 10.1016/j.mucimm.2025.01.010. Online ahead of print. ABSTRACT The ocular surface microbiota plays a critical role in maintaining corneal homeostasis, but its disruption and subsequent effects on corneal functions remain poorly understood. This study investigates how antibiotic-induced microbial depletion affects the corneal circadian transcriptome in C57BL/6J mice. Dysbiosis was induced using … Read more

Mucosal Immunol. 2025 Feb 5:S1933-0219(25)00013-3. doi: 10.1016/j.mucimm.2025.01.013. Online ahead of print. ABSTRACT Mitochondria are key regulators of inflammatory responses and mitochondrial dysfunction is closely linked to various inflammatory diseases. Increasing genetic and experimental evidence suggests that mitochondria play a critical role in inflammatory bowel disease (IBD). In the complex environment of the intestinal tract, intestinal … Read more

Mucosal Immunol. 2025 Feb 1:S1933-0219(25)00012-1. doi: 10.1016/j.mucimm.2025.01.012. Online ahead of print. ABSTRACT Innate lymphoid cells (ILC) have emerged as critical immune effectors with key roles in orchestrating the wider immune response. While ILC are relatively rare cells they are found enriched within discrete microenvironments, predominantly within barrier tissues. An emerging body of evidence implicates complex … Read more

Mucosal Immunol. 2025 Feb 1:S1933-0219(25)00009-1. doi: 10.1016/j.mucimm.2025.01.009. Online ahead of print. ABSTRACT The ocular mucosal surface regularly encounters external materials in the air and tear fluids. Microfold (M) cells, specialized epithelial cells for antigen uptake, are present in tear duct-associated lymphoid tissue (TALT) within the nasolacrimal sac; however, their immunological significance is unclear. We generated … Read more

Mucosal Immunol. 2025 Jan 31:S1933-0219(25)00011-X. doi: 10.1016/j.mucimm.2025.01.011. Online ahead of print. ABSTRACT Gut inflammatory diseases cause microbial dysbiosis. Human immunodeficiency virus-1 (HIV) infection disrupts intestinal integrity, subverts repair/renewal pathways, impairs mucosal immunity and propels microbial dysbiosis. However, microbial metabolic mechanisms driving repair mechanisms in virally inflamed gut are not well understood. We investigated the capability … Read more

Mucosal Immunol. 2025 Jan 28:S1933-0219(25)00008-X. doi: 10.1016/j.mucimm.2025.01.008. Online ahead of print. ABSTRACT Host response aimed at eliminating the infecting pathogen, as well as the pathogen itself, can cause tissue injury. Tissue injury leads to the release of a myriad of cellular components including mitochondrial DNA, which the host senses through pattern recognition receptors. How the … Read more

Mucosal Immunol. 2025 Jan 25:S1933-0219(25)00007-8. doi: 10.1016/j.mucimm.2025.01.007. Online ahead of print. ABSTRACT Maternal obesity is a condition with increasing prevalence worldwide, that correlates with negative infant outcomes. Here we performed an observational cross-sectional study, where peripheral blood and colostrum samples from 37 mothers with BMI between 18.5-25 or > 30 kg/m2 (21 and 16 mothers, … Read more

Mucosal Immunol. 2025 Jan 23:S1933-0219(25)00006-6. doi: 10.1016/j.mucimm.2025.01.006. Online ahead of print. ABSTRACT Our immune system and gut microbiota are intricately coupled from birth, both going through maturation during early life and senescence during aging almost in a synchronized fashion. The symbiotic relationship between the human host and microbiota is critically dependent on a healthy immune … Read more

Mucosal Immunol. 2025 Jan 21:S1933-0219(25)00001-7. doi: 10.1016/j.mucimm.2025.01.001. Online ahead of print. NO ABSTRACT PMID:39843282 | DOI:10.1016/j.mucimm.2025.01.001

Mucosal Immunol. 2025 Jan 20:S1933-0219(25)00003-0. doi: 10.1016/j.mucimm.2025.01.003. Online ahead of print. ABSTRACT Intestinal immune homeostasis relies on intestinal epithelial cells (IECs), which provide an efficient barrier, and warrant a state of tolerance between the microbiome and the mucosal immune system. Thus, proper epithelial microbial sensing and handling of microbes is key to preventing excessive immunity, … Read more

Mucosal Immunol. 2025 Jan 20:S1933-0219(25)00002-9. doi: 10.1016/j.mucimm.2025.01.002. Online ahead of print. ABSTRACT Dimeric IgA (dIgA) is the dominant antibody in many mucosal tissues. It is actively transported onto mucosal surfaces as secretory IgA (sIgA) which plays an integral role in protection against enteric pathogens, particularly in young children. Therapeutic strategies that deliver engineered, potently neutralizing … Read more

Mucosal Immunol. 2025 Jan 19:S1933-0219(25)00004-2. doi: 10.1016/j.mucimm.2025.01.004. Online ahead of print. ABSTRACT First- and secondhand smokers are at an increased risk for influenza virus (IFV)-related respiratory failure and death. Despite approved influenza antiviral treatments, there is an unmet need for treatments that can improve outcomes in populations at risk for respiratory failure, including tobacco users … Read more

Mucosal Immunol. 2025 Jan 15:S1933-0219(25)00005-4. doi: 10.1016/j.mucimm.2025.01.005. Online ahead of print. ABSTRACT Immunoglobulin A (IgA), the most abundantly produced antibody at mucosal surfaces, is thought to play key roles in immune responses to respiratory and enteric pathogens and in the regulation of commensal colonization. Low IgA levels have been associated with recurrent infections and immune … Read more

Mucosal Immunol. 2025 Jan 2:S1933-0219(24)00136-3. doi: 10.1016/j.mucimm.2024.12.013. Online ahead of print. ABSTRACT Mucosal tissues, including those in the respiratory and gastrointestinal tracts, are critical barrier surfaces for pathogen invasion. Infections at these sites not only trigger local immune response, but also recruit immune cells from other tissues. Emerging evidence in mouse models and human samples … Read more

Mucosal Immunol. 2024 Dec 31:S1933-0219(24)00137-5. doi: 10.1016/j.mucimm.2024.12.014. Online ahead of print. ABSTRACT Inflammatory bowel diseases (IBDs) are characterized by unrestrained innate and adaptive immune responses and compromised intestinal epithelial barrier integrity. Regulatory T (Treg) cells are crucial for maintaining self-tolerance and immune homeostasis in intestinal tissues. Prostaglandin E2 (PGE2), a bioactive lipid compound derived from … Read more

Mucosal Immunol. 2024 Dec 31:S1933-0219(24)00138-7. doi: 10.1016/j.mucimm.2024.12.015. Online ahead of print. ABSTRACT Diabetes mellitus is associated with an increased risk of pneumonia, often caused by so-called typical and atypical pathogens including Streptoccocus pneumoniae and Legionella pneumophila, respectively. Here, we employed a variety of mouse models to investigate how diabetes influences pulmonary antibacterial immunity. Following intranasal … Read more

Mucosal Immunol. 2024 Dec 21:S1933-0219(24)00135-1. doi: 10.1016/j.mucimm.2024.12.012. Online ahead of print. ABSTRACT Neuro-immune interactions within barrier organs, such as lung, gut, and skin, are crucial in regulating tissue homeostasis, inflammatory responses, and host defence. Our rapidly advancing understanding of peripheral neuroimmunology is transforming the field of barrier tissue immunology, offering a fresh perspective for developing … Read more

Mucosal Immunol. 2024 Dec 20:S1933-0219(24)00133-8. doi: 10.1016/j.mucimm.2024.12.010. Online ahead of print. ABSTRACT The precise role of neutrophil-derived reactive oxygen species (ROS) in combating bacterial uropathogens during urinary tract infections (UTI) remains largely unexplored. In this study, we elucidate the antimicrobial significance of NADPH oxidase 2 (NOX2)-derived ROS, as opposed to mitochondrial ROS, in facilitating neutrophil-mediated … Read more

Mucosal Immunol. 2024 Dec 19:S1933-0219(24)00134-X. doi: 10.1016/j.mucimm.2024.12.011. Online ahead of print. NO ABSTRACT PMID:39708956 | DOI:10.1016/j.mucimm.2024.12.011

Mucosal Immunol. 2024 Dec 19:S1933-0219(24)00132-6. doi: 10.1016/j.mucimm.2024.12.009. Online ahead of print. ABSTRACT The murine uterus contains three subsets of innate lymphoid cells (ILCs). Innate lymphoid cell type 1 (ILC1) and conventional natural killer (cNK) cells seed the uterus before puberty. Tissue-resident NK (trNK) cells emerge at puberty and vary in number during the estrous cycle. … Read more

Mucosal Immunol. 2024 Dec 13:S1933-0219(24)00130-2. doi: 10.1016/j.mucimm.2024.12.007. Online ahead of print. ABSTRACT Decidual CD8+T (dCD8+T) cells are pivotal in the maintenance of the delicate balance between immune tolerance towards the fetus and immune resistance against pathogens. The endometrium and decidua represent uterine environments before and during pregnancy, respectively, and the composition and phenotypic alterations of … Read more

Mucosal Immunol. 2024 Dec 13:S1933-0219(24)00129-6. doi: 10.1016/j.mucimm.2024.12.006. Online ahead of print. ABSTRACT We aimed to elucidate the dynamic changes in short-chain fatty acids (SCFA) produced by the gut microbiota following smoking exposure and their role in chronic obstructive pulmonary disease (COPD) pathogenesis. SCFA concentrations were measured in human plasma, comparing non-smokers (n = 6) and … Read more

Mucosal Immunol. 2024 Dec 13:S1933-0219(24)00131-4. doi: 10.1016/j.mucimm.2024.12.008. Online ahead of print. ABSTRACT Despite the central role of cytokines in mediating inflammation that underlies a range of childhood diseases, cytokine testing remains primarily limited to research settings and surrogate markers of inflammation are often used to inform clinical diagnostic and treatment decisions. There are currently no … Read more

Mucosal Immunol. 2024 Dec 13:S1933-0219(24)00128-4. doi: 10.1016/j.mucimm.2024.12.005. Online ahead of print. ABSTRACT Despite advances in our understanding of their diagnosis and treatment, pediatric allergies impose substantial burdens on affected children, families, and healthcare systems. Further, the prevalence of allergic diseases has dramatically increased over the past half-century, leading to additional concerns and concerted efforts to … Read more

Mucosal Immunol. 2024 Dec 11:S1933-0219(24)00126-0. doi: 10.1016/j.mucimm.2024.12.003. Online ahead of print. ABSTRACT In complex organisms, functional units must interact cohesively to maintain homeostasis, especially within mucosal barriers that house diverse, specialized cell exposed to constant environmental challenges. Understanding how homeostasis at mucosal barriers is maintained and how its disruption can lead to autoimmune diseases or … Read more

Mucosal Immunol. 2024 Dec 9:S1933-0219(24)00127-2. doi: 10.1016/j.mucimm.2024.12.004. Online ahead of print. ABSTRACT The role of innate receptors in initiating the early inflammatory response to helminth larval stages in affected tissues during their life cycle within the host remains poorly understood. Given its pivotal role in detecting microbial elements and eliciting immune responses, exploring the NOD1 … Read more

Mucosal Immunol. 2024 Dec 9:S1933-0219(24)00124-7. doi: 10.1016/j.mucimm.2024.12.001. Online ahead of print. ABSTRACT Interleukin (IL)-33 is released following tissue damage, causing airway inflammation and remodelling via reduced IL-33 (IL-33red)/serum stimulation-2 (ST2) and oxidised IL-33 (IL-33ox)/receptor for advanced glycation end products (RAGE)/epidermal growth factor receptor (EGFR) pathways. This study aimed to identify associations of IL-33 with clinical … Read more

Mucosal Immunol. 2024 Dec 9:S1933-0219(24)00125-9. doi: 10.1016/j.mucimm.2024.12.002. Online ahead of print. ABSTRACT Recent evidence suggests that the gut microbiota can influence pain sensitivity, highlighting the potential for microbiota-targeted pain interventions. During early life, both the microbiota and nociceptors are fine-tuned and respond to environmental factors, however, little is known about how they interact with each … Read more

Mucosal Immunol. 2024 Nov 24:S1933-0219(24)00115-6. doi: 10.1016/j.mucimm.2024.11.007. Online ahead of print. ABSTRACT Interleukin (IL)-33 is a key responder to intestinal injury and inflammation. In the colon, it is expressed by several cell populations, with the specific cellular source likely determining its role. The colonic epithelium expresses IL-33; however, the factors controlling its production and the … Read more

Mucosal Immunol. 2024 Nov 24:S1933-0219(24)00117-X. doi: 10.1016/j.mucimm.2024.11.009. Online ahead of print. ABSTRACT Host-directed therapy, using nasal administration of the Toll-like receptor 5 agonist flagellin in combination with antibiotics, has proven effective against pneumococcal pneumonia. In this study, we investigated the immune mechanisms underlying the therapy-induced protective effects. Transcriptomic analysis of lung tissue during infection revealed … Read more

Mucosal Immunol. 2024 Nov 23:S1933-0219(24)00116-8. doi: 10.1016/j.mucimm.2024.11.008. Online ahead of print. ABSTRACT CD4+ memory T cell (TM) reactivation drives chronicity in inflammatory bowel disease (IBD), including Crohn’s disease (CD) and ulcerative colitis. Defects driving loss of TM regulation likely differ between patients but remain undefined. In health, approximately 40 % of circulating gut-homing CD38+TM, express … Read more

Mucosal Immunol. 2024 Nov 22:S1933-0219(24)00111-9. doi: 10.1016/j.mucimm.2024.11.003. Online ahead of print. ABSTRACT The recurrent herpes simplex virus-1 (HSV-1) infection of the cornea can cause the development of herpes stromal keratitis (HSK). This chronic immunoinflammatory condition is a major cause of infection-induced vision loss. The previous episodes of HSK increase the risk of future recurrences in … Read more

Mucosal Immunol. 2024 Nov 22:S1933-0219(24)00114-4. doi: 10.1016/j.mucimm.2024.11.005. Online ahead of print. ABSTRACT Strongyloides ratti is a helminth parasite that displays tissue-migrating and intestinal life stages. Myeloid C-type lectin receptors (CLRs) are pattern recognition receptors that recognize pathogen-derived ligands and initiate immune responses. To date, the role of CLRs in S. ratti infection has not been … Read more

Mucosal Immunol. 2024 Nov 22:S1933-0219(24)00113-2. doi: 10.1016/j.mucimm.2024.11.006. Online ahead of print. ABSTRACT IgA antibodies have an important role in clearing mucosal pathogens. In this study, we have examined the contribution of IgA to the immune control of the gastrointestinal bacterial pathogens Helicobacter pylori and Citrobacter rodentium. Both bacteria trigger a strong local IgA response that … Read more

Mucosal Immunol. 2024 Nov 21:S1933-0219(24)00112-0. doi: 10.1016/j.mucimm.2024.11.004. Online ahead of print. ABSTRACT The fungal community of the skin microbiome is dominated by a single genus, Malassezia. Besides its symbiotic lifestyle at the host interface, this commensal yeast has also been associated with diverse inflammatory skin diseases in humans and pet animals. Stable colonization is maintained … Read more

Mucosal Immunol. 2024 Nov 8:S1933-0219(24)00110-7. doi: 10.1016/j.mucimm.2024.11.002. Online ahead of print. ABSTRACT There is an unmet need for effectively treating dry eye disease (DED), a T cell-mediated chronic, inflammatory ocular surface disorder. Given the potential of nonneuronal adrenergic system in modulating T cell response, we herein investigated the therapeutic efficacy and the underlying mechanisms of … Read more

Mucosal Immunol. 2024 Nov 7:S1933-0219(24)00109-0. doi: 10.1016/j.mucimm.2024.11.001. Online ahead of print. ABSTRACT Altered intestinal immune homeostasis leads to chronic inflammation in Crohn’s disease (CD). To address disease- and tissue-specific alterations, we performed a T cell-centric mass cytometry analysis of peripheral and intestinal lymphocytes from patients with CD and healthy donors’ PBMCs. Chronic intestinal inflammation enforced … Read more

Mucosal Immunol. 2023 Oct 27:S1933-0219(23)00081-8. doi: 10.1016/j.mucimm.2023.10.003. Online ahead of print. NO ABSTRACT PMID:39491094 | DOI:10.1016/j.mucimm.2023.10.003

Mucosal Immunol. 2023 Oct 27:S1933-0219(23)00082-X. doi: 10.1016/j.mucimm.2023.10.004. Online ahead of print. ABSTRACT Endogenous retroelements play vital roles in sustaining immune homeostasis. Activation of endogenous retroelements can trigger cGAS/STING pathway and downstream pro-inflammatory cytokine production. M1 macrophages, which can be induced by pro-inflammatory cytokines, are involved in the development of colitis. Here we aimed to determine … Read more

Mucosal Immunol. 2024 Oct 17:S1933-0219(24)00105-3. doi: 10.1016/j.mucimm.2024.10.002. Online ahead of print. ABSTRACT The lungs represent a dynamic microenvironment where airway macrophages (AMs) are the major lung-resident macrophages. AMs dictate the balance between tissue homeostasis and immune activation and thus have contradictory functions by maintaining tolerance and tissue homeostasis, as well as initiating strong inflammatory responses. … Read more

Mucosal Immunol. 2024 Oct 14:S1933-0219(24)00108-9. doi: 10.1016/j.mucimm.2024.10.005. Online ahead of print. ABSTRACT To establish protection against harmful foreign antigens, the small intestine harbors guardian sites called Peyer’s patches (PPs). PPs take up antigens through microfold (M) cells and transfer them to the sub-epithelial dome (SED), which contains a high density of mononuclear phagocytes (MPs), for … Read more

Mucosal Immunol. 2024 Oct 11:S1933-0219(24)00107-7. doi: 10.1016/j.mucimm.2024.10.004. Online ahead of print. ABSTRACT Infections by enteric virus and intestinal inflammation are recognized as a leading cause of deadly gastroenteritis, and NLRP6 and NLRP9b signaling control these infection and inflammation. However, the regulatory mechanisms of the NLRP6 and NLRP9b signaling in enteric viral infection remain unexplored. In … Read more

Mucosal Immunol. 2024 Oct 8:S1933-0219(24)00106-5. doi: 10.1016/j.mucimm.2024.10.003. Online ahead of print. ABSTRACT While much is known about the functional effects of type 2 cytokines interleukin (IL)-4, IL-5 and IL-13 in homeostasis and disease, we still poorly understand the functions of IL-9. Chronic inflammation seen in allergic diseases, autoimmunity and cancer is however frequently accompanied by … Read more

Mucosal Immunol. 2024 Oct 5:S1933-0219(24)00104-1. doi: 10.1016/j.mucimm.2024.10.001. Online ahead of print. ABSTRACT Epithelial barriers such as the skin, lung, and gut, in addition to having unique physiologic functions, are designed to preserve tissue homeostasis upon challenge with a variety of allergens, irritants, or pathogens. Both the innate and adaptive immune systems play a critical role … Read more

Mucosal Immunol. 2024 Sep 27:S1933-0219(24)00099-0. doi: 10.1016/j.mucimm.2024.09.006. Online ahead of print. ABSTRACT Atopic diseases such as Eosinophilic Esophagitis (EoE) often progress into fibrosis (FS-EoE), compromising organ function with limited targeted treatment options. Mechanistic understanding of FS-EoE progression is confounded by the lack of preclinical models and the heavy focus of research on eosinophils themselves. We … Read more

Mucosal Immunol. 2024 Sep 25:S1933-0219(24)00097-7. doi: 10.1016/j.mucimm.2024.09.004. Online ahead of print. ABSTRACT Inflammatory bowel disease (IBD) chronicity results from memory T helper cell (Tmem) reactivation. Identifying patient-specific immunotypes is crucial for tailored treatment. We conducted a comprehensive study integrating circulating immune proteins and circulating Tmem, with intestinal tissue histology and mRNA analysis, in therapy-naïve pediatric … Read more

Mucosal Immunol. 2024 Sep 16:S1933-0219(24)00096-5. doi: 10.1016/j.mucimm.2024.09.003. Online ahead of print. ABSTRACT The host-microbiome axis has been implicated in promoting anti-inflammatory immune responses. Yet, the underlying molecular mechanisms of commensal-mediated IL-10 production by regulatory B cells (Bregs) are not fully elucidated. Here, we demonstrate that bacterial CpG motifs trigger the signaling downstream of TLR9 promoting … Read more

Mucosal Immunol. 2024 Sep 8:S1933-0219(24)00091-6. doi: 10.1016/j.mucimm.2024.08.011. Online ahead of print. ABSTRACT Dietary micronutrients, particularly vitamin B12 (VB12), profoundly influence the physiological maintenance and function of intestinal cells. However, it is still unclear whether VB12 modulates the transcriptional and metabolic programming of ileal macrophages (iMacs), thereby contributing to intestinal homeostasis. Using multiomic approaches, we demonstrated … Read more

Mucosal Immunol. 2024 Sep 7:S1933-0219(24)00095-3. doi: 10.1016/j.mucimm.2024.09.002. Online ahead of print. ABSTRACT Postoperative cognitive dysfunction (POCD) is a prevalent neurological complication that can impair learning and memory for days, months, or even years after anesthesia/surgery. POCD is strongly associated with an altered composition of the gut microbiota (dysbiosis), but the accompanying metabolic changes and their … Read more

Mucosal Immunol. 2024 Sep 7:S1933-0219(24)00094-1. doi: 10.1016/j.mucimm.2024.09.001. Online ahead of print. ABSTRACT The transcriptomic signatures that shape responses of innate lymphoid cells (ILCs) have been well characterised, however post-transcriptional mechanisms which regulate their development and activity remain poorly understood. We demonstrate that ILC groups of the intestinal lamina propria express mature forms of microRNA-142 (miR-142), … Read more

Mucosal Immunol. 2024 Sep 7:S1933-0219(24)00093-X. doi: 10.1016/j.mucimm.2024.08.012. Online ahead of print. ABSTRACT Inflammation of the ileum, or ileitis, is commonly caused by Crohn’s disease (CD) but can also accompany ulcerative colitis (backwash ileitis), infections or drug-related damage. Oxidative tissue injury triggered by reactive oxygen species (ROS) is considered part of the ileitis etiology. However, not … Read more

Mucosal Immunol. 2024 Sep 5:S1933-0219(24)00092-8. doi: 10.1016/j.mucimm.2024.08.010. Online ahead of print. ABSTRACT The impact of dietary fiber on intestinal T cell development is poorly understood. Here we show that a low fiber diet reduces MHC-II antigen presentation by small intestinal epithelial cells (IECs) and consequently impairs development of CD4+CD8αα+ intraepithelial lymphocytes (DP IELs) through changes … Read more

Mucosal Immunol. 2024 Aug 21:S1933-0219(24)00089-8. doi: 10.1016/j.mucimm.2024.08.008. Online ahead of print. ABSTRACT Acute respiratory distress syndrome (ARDS) is a life-threatening condition characterized by severe inflammation and pulmonary dysfunction. Despite advancements in critical care, effective pharmacological interventions for ARDS remain elusive. While Janus kinase 2 (JAK2) inhibitors have emerged as an innovative treatment for numerous autoinflammatory … Read more

Mucosal Immunol. 2024 Aug 20:S1933-0219(24)00088-6. doi: 10.1016/j.mucimm.2024.08.007. Online ahead of print. ABSTRACT PLX5622 is a small molecular inhibitor of the CSF1 receptor (CSF1R) and is widely used to deplete macrophages within the central nervous system (CNS). We investigated the impact of PLX5622 treatment in wild-type C57BL/6 mice and discovered that one-week treatment with PLX5622 was … Read more

Mucosal Immunol. 2024 Sep 25:S1933-0219(24)00098-9. doi: 10.1016/j.mucimm.2024.09.005. Online ahead of print. ABSTRACT Inflammatory bowel disease (IBD) is characterized by very severe intestinal inflammation associated with extra-intestinal manifestations. One of the most critical ones is bone destruction, which remains a major cause of morbidity and a risk factor for osteopenia and osteoporosis in IBD patients. In … Read more

Mucosal Immunology, Published online: 21 November 2022; doi:10.1038/s41385-022-00578-9Mucosal immunization with a delta-inulin adjuvanted recombinant spike vaccine elicits lung-resident immune memory and protects mice against SARS-CoV-2

Mucosal Immunology, Published online: 15 November 2022; doi:10.1038/s41385-022-00579-8Intestinal epithelium in early life

Mucosal Immunology, Published online: 13 November 2022; doi:10.1038/s41385-022-00577-wEpithelial dysfunction is prevented by IL-22 treatment in a Citrobacter rodentium-induced colitis model that shares similarities with inflammatory bo…

Mucosal Immunology, Published online: 09 November 2022; doi:10.1038/s41385-022-00576-xSeverity of neonatal influenza infection is driven by type I interferon and oxidative stress

Mucosal Immunology, Published online: 03 November 2022; doi:10.1038/s41385-022-00574-zResistance is futile? Mucosal immune mechanisms in the context of microbial ecology and evolution

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