A recent study has provided the first side-by-side comparison of how three major COVID-19 vaccine types differ in triggering immune responses and sustaining protection, according to an analysis published in JCI Insight.
Bacteria may be the next frontier in cancer treatment, according to a team led by researchers at Penn State that devised a new approach of creating bacteria-derived mixtures—or cocktails—to help fight bladder cancer. They tested their mixtures of good …
Scientists at The University of Texas at El Paso have found a promising new target in the fight against high-grade serous carcinoma, an aggressive form of ovarian cancer. Less than 50% of women survive five years after diagnosis, according to the team.
Researchers led by a team from Mass General Brigham and the Ragon Institute have discovered why some people living with HIV who are given a treatment called broadly neutralizing anti-HIV antibodies (bNAbs) can safely stop taking standard, lifelong HIV …
New research published in The Journal of Immunology suggests that a lack of dietary iron can negatively affect the ability of immune cells to respond to viral infection in the lungs. In mice with dietary iron deficiency and influenza, immune cells stru…
Scientists led by Stephanie Eisenbarth, MD, Ph.D., the Roy and Elaine Patterson Professor of Medicine and director of the Center for Human Immunobiology, have discovered how critical IgA antibodies are produced through unexpected cellular pathways, fin…
About 40 million people worldwide are living with HIV infection. In the United Kingdom, there are approximately 100,000 people affected. If the infection is not treated, the body will eventually be unable to defend itself against pathogens or tumor cel…
In several disease conditions, including infections and cancers, innate immune activation and nutrient scarcity occur together. A study from St. Jude Children’s Research Hospital, published in Cell, found that this combination causes a unique type of …
A new study from UC San Francisco shows it may be possible to control HIV without long-term antiviral treatment—an advance that points the way toward a possible cure for a disease that affects 40 million people around the world.
HIV treatment has delivered life-altering advantages. Antiretroviral therapy has led to a reduced mortality and improved life expectancy for people living with HIV. Nearly 41 million people were living with HIV in 2024. Eastern and southern Africa acco…
An international team led by two Université de Montréal researchers has unveiled how a molecule capable of opening the “shell” of HIV improves the elimination of infected cells.
Scientists have uncovered how too much sunlight can flip a hidden switch inside skin cells that makes inflammation spiral out of control and increases the risk of cancer. Their research reveals that UV radiation breaks down a protective protein called …
A new study published in the Journal of Clinical Investigation has identified biomarkers that predict the likelihood of a patient developing checkpoint inhibitor-associated autoimmune diabetes before they are treated with immune checkpoint inhibitors. …
A new study published in the Journal of Clinical Investigation has identified biomarkers that predict the likelihood of a patient developing checkpoint inhibitor-associated autoimmune diabetes before they are treated with immune checkpoint inhibitors. …
Belgian scientists from VIB and Ghent University (UGent), together with Danish collaborators, have uncovered compelling evidence that early-infancy infection with respiratory syncytial virus (RSV) significantly increases the risk of developing childhoo…
Regulatory T cells (Treg cells), a specialized type of immune cell, are usually seen as “peacekeepers” that prevent excessive immune attacks. Surprisingly, a new study published in Signal Transduction and Targeted Therapy shows that Treg cells utilize …
In preclinical studies, researchers found that priming the immune system with a Treg-expanding therapy before stem cell transplant boosted survival, protected vital organs, and promoted a balanced gut microbiome—offering hope for safer, more effective …
Scientists studying young adults with obesity discovered early indicators of brain stress that resemble patterns seen in cognitive impairment. The group showed higher inflammation, signs of liver strain and elevated neurofilament light chain, a marker …
Rheumatoid arthritis begins years before pain ever appears, and scientists have now mapped the hidden immune battle that unfolds long before symptoms. By studying people with RA-linked antibodies over seven years, researchers discovered sweeping inflam…
The hepatitis C virus—HCV—can persist in the livers of those infected and even lead to liver disease or failure in extreme cases. It affects tens of millions of people worldwide and there is no vaccine to prevent infection, but effective treatment can …
Researchers at Stanford found a way to cure or prevent Type 1 diabetes in mice using a combined blood stem cell and islet cell transplant. The procedure creates a hybrid immune system that stops autoimmune attacks and eliminates the need for immune-sup…
Scientists have discovered how a mitochondrial mutation rewires immune function in a model of inherited primary mitochondrial disorders, which often lead to severe disability and death. They have discovered that this single inherited mutation causes wh…
Cedars-Sinai investigators may have figured out why certain immunosuppressive treatments don’t work well in rheumatoid arthritis. In a study published in Science Immunology, scientists trace the problem to specific changes that occur in immune cells wi…
Researchers at the University of Arizona have uncovered a previously unknown population of circulating immune cells that play a critical role in fibrosis, the buildup of scar tissue that can lead to organ failure and disfigurement. The findings, publis…
Researchers at The University of Texas MD Anderson Cancer Center have found that renal medullary carcinoma (RMC) cells use an adaptive mechanism called “myeloid mimicry” to hide from the immune system and promote disease hyperprogression after immunoth…
A new paper from the University of Kansas overturns the idea that a “risk gene” carried by millions of people worldwide influences production of type 1 interferon, a workhorse of the immune system. The work is published in the journal ImmunoHorizons.
An international research team led by scientists from Bern and Charité—Universitätsmedizin Berlin has identified a previously unknown function of the intestinal nervous system.
Pancreatic cancer is among the deadliest forms of cancer, with most patients diagnosed after the disease has already spread throughout the body. The five-year survival rate for metastatic cases hovers around 2–3%, and median survival is often measured …
Lecanemab, sold under the name Leqembi, is a monoclonal antibody therapy for Alzheimer’s disease that clears toxic amyloid plaques and delays cognitive decline. Researchers from VIB and KU Leuven have now demonstrated the mechanism behind it for the fi…
“I just can’t make it tonight. You have fun without me.” Across much of the animal kingdom, when infection strikes, social contact shuts down. A new study details how the immune and central nervous systems implement this sickness behavior.
Have you ever found yourself searching for a word you should know, forgetting what you were just doing, or feeling mentally foggy for no obvious reason?
Biomedical research that began at the University of Virginia School of Medicine has yielded a much-needed new treatment for patients with the deadliest form of blood cancer.
It has only recently become known that two parallel systems of blood formation exist in the body, originating from different precursor cells. Researchers at the German Cancer Research Center (DKFZ) have developed a method to examine both systems separa…
Researchers from the Institute of Human Virology (IHV) at the University of Maryland School of Medicine have discovered how a specific type of immune cell may contribute to the persistence of HIV infections. The finding offers new insight into why the …
Researchers at the Icahn School of Medicine at Mount Sinai have discovered how to reverse aging in blood-forming stem cells in mice by correcting defects in the stem cell’s lysosomes. The breakthrough, published in Cell Stem Cell, identifies lysosomal …
A new study published in the Journal of Biological Chemistry from UC Davis Comprehensive Cancer Center finds that TIGIT, an immune checkpoint receptor targeted by cancer immunotherapy drugs, triggers a different response in rhesus macaques compared to …
Studying T cells, the immune cells most responsible for responding to infections and cancers, just received a significant boost in the form of a new technique from St. Jude Children’s Research Hospital. While T-cell analysis can reveal much about how t…
Amid concerns about the simultaneous spread of multiple respiratory diseases, such as colds and influenza, with the change of seasons in current times, a clinical study has scientifically proven that kimchi, a traditional Korean fermented food, enhance…
Researchers at the LSU LCMC Health Cancer Center have published findings in npj Breast Cancer that shed new light on triple-negative breast cancer (TNBC), one of the most aggressive forms of breast cancer.
Beneath the surface of your gut lies a vast network of neurons—as many as in your spinal cord. New research from the Champalimaud Foundation (CF) in Lisbon shows that in mice this “second brain” helps decide whether the immune system should go into att…
About 5 million people worldwide live with the autoimmune condition lupus. This condition can cause a range of symptoms, including tiredness, fever, joint pain and a characteristic butterfly-shaped rash across the cheeks and nose.
Detailed mapping of CD4⁺ T cells from children with systemic lupus erythematosus (SLE) has revealed distinct immune cell subsets with likely roles in disease pathogenesis, according to a study led by Weill Cornell Medicine investigators. The findings a…
Liver transplants often save the lives of seriously ill patients. However, there remains a risk that the body will reject the new organ. Doctors distinguish between acute and chronic rejection. While acute rejection is easy to diagnose and treat, chron…
A new nasal-delivered nanotherapy shows promise against aggressive glioblastoma tumors. By activating the STING immune pathway using gold-core spherical nucleic acids, researchers were able to reach the brain without invasive surgery. When paired with …
Memory T cells are a special type of white blood cell that “remember” past infections and vaccines, helping our bodies to quickly respond if we encounter the same germs again. These cells are found throughout the body: some circulate in the blood, whil…
Ulcerative colitis (UC) is one of the most common inflammatory bowel diseases, a lifelong condition that can cause chronic inflammation and ulcers in the lining of the large intestine. This can lead to symptoms such as rectal pain and bleeding, and per…
Researchers at Washington University School of Medicine in St. Louis, along with collaborators at Northwestern University, have developed a noninvasive approach to treat one of the most aggressive and deadly brain cancers. Their technology uses precise…
Type 1 diabetes (T1D) impacts nearly two million Americans, and by the time most people learn they have it, most of the body’s insulin-producing cells are destroyed. Now, pinpointing a hidden group of immune “attack” cells in the pancreatic lymph nodes…
Despite recommendations for posttreatment surveillance in lung cancer patients, there is wide variability in the follow-up care that lung cancer patients receive. A recent study, led by senior author Leah Backhus, MD, MPH, Professor of Cardiothoracic S…
Researchers at the Icahn School of Medicine at Mount Sinai and collaborators have created the most comprehensive map to date showing how antibodies attach to the SARS-CoV-2 virus, which causes COVID-19, and how viral mutations weaken that attachment.
At the cellular level, the mechanics of how muscle tissue repair occurs gets complicated. There are significant differences between, say, tearing a muscle in a sports injury versus muscle tissue wasting away from diseases like muscular dystrophy.
A new study led by researchers at The University of Texas MD Anderson Cancer Center shows that a specific subset of mutations in the POLE gene is strongly associated with durable responses to immunotherapy in patients with metastatic colorectal cancer …
A research team led by Professor Eijiro Miyako at the Graduate School of Advanced Science and Technology, Japan Advanced Institute of Science and Technology (JAIST), has discovered that the marine bacterium Photobacterium angustum demonstrates remarkab…
A pioneering preclinical study has shown that CAR T cell therapy—a personalized form of immunotherapy used in cancer treatment—could be a highly effective tool against atherosclerosis, the condition where a build-up of plaque in the arteries reduces bl…
With a five-year survival rate of less than 5%, glioblastoma is one of the most aggressive types of brain cancer. Until now, all available treatments, including immunotherapy—which involves strengthening the immune system to fight cancer—have proved di…
Major depressive disorder (MDD) is characterized by a lowered mood and loss of interest, contributing not only to difficulties in academic and professional life but also as a major cause of suicide in South Korea. However, there are currently no object…
Researchers found that hot tubs raise core body temperature more effectively than traditional or infrared saunas, leading to stronger boosts in blood flow and immune activity. Only hot-water immersion produced measurable changes in inflammatory markers…
Immunotherapy, which harnesses our body’s own immune system to fight cancer, has revolutionized modern oncology. Yet despite its success with several cancers, many patients still fail to respond to therapy or experience relapse later on. Scientists hav…
A clinical oncology research team at the LKS Faculty of Medicine, the University of Hong Kong (HKUMed), in collaboration with the US National Cancer Institute (NCI), has developed an innovative big data platform, called the “Cancer Immunology Data Engi…
An international research group directed by UMC Utrecht has developed and characterized two first-in-class antibodies that specifically block the high-affinity IgG receptor FcγRI. Their findings open new perspectives for therapeutic modulation of FcγRI…
Polycystic kidney disease (PKD) is a debilitating hereditary condition in which fluid-filled sacs form and proliferate in the kidneys. Over time, the painful, growing cysts rob the organs of their function, often leading to dialysis in advanced cases. …
Researchers discovered that chronic inflammation fundamentally remodels the bone marrow, allowing mutated stem cell clones to quietly gain dominance with age. Reprogrammed stromal cells and interferon-responsive T cells create a self-sustaining inflamm…
Alzheimer’s disease (AD) is a highly debilitating neurodegenerative disease characterized by the progressive loss of memory and decline of mental functions. Earlier research has uncovered some of the neural and biological underpinnings of AD, but many …
A new study led by researchers at the Johns Hopkins Kimmel Cancer Center found that patients with advanced basal cell carcinoma (BCC) may benefit from receiving immunotherapy earlier in the course of treatment.
Artificial intelligence (AI) can predict how well patients with rectal cancer will respond to treatment by analyzing standard tissue samples taken during diagnosis, finds a new study from researchers at UCL and UCLH.
A combination of blood stem cell and pancreatic islet cell transplant from an immunologically mismatched donor completely prevented or cured type 1 diabetes in mice in a study by Stanford Medicine researchers. Type 1 diabetes arises when the immune sys…
Our body’s immune system is quick to spring into action when it spots a foreign object that shouldn’t be there. Sometimes the same defense mechanism can get confused and end up attacking the very cells it’s meant to protect, a phenomenon known as an au…
Chronic pain might quietly push people toward developing high blood pressure—and the more widespread the pain, the greater the danger. A massive analysis of over 200,000 adults uncovered strong links between long-lasting pain, depression, inflammation,…
A new study led by University of Toronto researchers has shown that immune cells in the gut follow an atypical pathway to produce antibodies that provide long-term protection against viruses.
Researchers at the Technion—Israel Institute of Technology Faculty of Biology have identified a unique mechanism involved in the aging of the immune system—along with a framework for enhancing its function in older individuals. The study, published in …
A new study has discovered a molecular signal that tumors exploit to exhaust the T cells meant to destroy them—and how silencing that signal could revive the body’s immunity.
Researchers at the University of California San Diego School of Medicine have identified a promising new therapy for triple-negative breast cancer (TNBC), which is among the most aggressive and difficult-to-treat forms of the disease.
Over the 40-year history of the University of Colorado Cancer Center, its investigators have answered many questions about cancer—what causes it, how to prevent it, and how to treat it. Those discoveries have helped many people with cancer live longer,…
Cells have an internal skeleton that maintains their structure and also drives their movement. Known as the cytoskeleton, this scaffold is composed of a network of dynamic filaments made of a protein called actin.
New results from a multicenter clinical trial show that combining immunotherapy drugs nivolumab and ipilimumab significantly improves treatment response in patients with advanced and difficult-to-treat cancers. The trial results have been pre-published…
Yale School of Medicine (YSM) researchers have made key breakthroughs in understanding how to treat fibrotic diseases such as scleroderma and graft-versus-host disease.
Researchers at the Kennedy Institute have provided the most comprehensive overview to date of how the distinctive segmented nucleus of neutrophils influences their function in health and disease.
A new Cedars-Sinai Cancer study shows that patients with advanced liver cancer who receive immunotherapy to shrink their tumors have improved outcomes after liver transplant or tumor removal.
The immune system faces a delicate balancing act: It must be aggressive enough to fight infections and cancer, yet restrained enough to avoid attacking the body’s own tissues.
Prior exposure to coronaviruses that cause ordinary colds can boost the immune system’s ability to attack a vulnerable site on the COVID-19-causing coronavirus SARS-CoV-2, according to a study led by investigators at Weill Cornell Medicine.
Researchers have uncovered and then overcome an obstacle that has led to the failure of pioneering efforts in xenotransplantation, in which an animal kidney is transplanted into a human.
Scientists are trying a revolutionary new approach to treat rheumatoid arthritis, multiple sclerosis, lupus and other devastating autoimmune diseases—by reprogramming patients’ out-of-whack immune systems.
A research team led by the Department of Clinical Oncology, Center of Cancer Medicine, School of Clinical Medicine, LKS Faculty of Medicine, the University of Hong Kong (HKUMed), has identified a critical factor contributing to the failure of liver can…
Scientists have discovered strange microscopic structures in the blood of people with Long COVID—clusters of tiny microclots tangled together with sticky immune webs known as neutrophil extracellular traps, or NETs. These combined structures show up fa…
A naturally-occurring protein that tends to be expressed at higher levels in breast cancer cells boosts the effectiveness of some anticancer agents, including doxorubicin, one of the most widely used chemotherapies, and a preclinical drug known as ErSO…
The Society of Nuclear Medicine and Molecular Imaging (SNMMI) has released a position paper outlining the education, training, and experience needed to ensure the safe and effective delivery of radiopharmaceutical therapy (RPT), a rapidly growing form …
Last year, researchers at the University of California, Riverside, developed a novel “molecular crowbar” strategy to degrade the oncogenic enzyme Pin1, a protein that is overexpressed in many tumors, including pancreatic cancer. They designed compounds…
One of humanity’s most ubiquitous infectious pathogens bears the blame for the chronic autoimmune condition called systemic lupus erythematosus (lupus), Stanford Medicine investigators and their colleagues have found.
Colorectal cancer precursor lesions are benign growths that can develop into colorectal cancer (CRC) over time, through either a conventional or serrated pathway. Understanding how the immune system reacts to these precursor lesions could further the u…
Cancer Center at Illinois (CCIL) Program Leader Erik Nelson’s lab made an important discovery about the relationship between cholesterol and breast cancer progression with crucial implications for breast cancer therapeutics.
A new study from the Icahn School of Medicine at Mount Sinai helps explain why some people with multiple myeloma, a type of blood cancer, stay in remission for many years after receiving CAR T cell therapy, while others see their cancer return sooner. …
The weeks leading up to a major surgery can be a time of uncertainty and worry for patients, many of whom anticipate the need for rehabilitation to get back on their feet. But if patients improve their physical and mental health prior to surgery, a pro…
As the immune system ages, it reacts more slowly to pathogens, vaccines become less effective, and the risk of cancer increases. At the same time, the immune system follows a 24-hour rhythm, as the number and activity of many immune cells fluctuate thr…
New research comparing four different flu vaccines found that the ability of the vaccines to activate cells of the immune system that help to protect against infection varied greatly depending on the vaccine type and age of the patient. Researchers say…
Researchers at the University of Southampton have identified a new subtype of lymphoma that could pave the way to improved and more targeted treatments for some blood cancer patients. The cancer scientists and biologists have also found that lymphoma c…
New clinical research has identified a blood test that can reveal which women are more likely to respond to a particular treatment for ovarian cancer, known as PARP inhibitor therapy.
