Cancer Immunol Res. 2025 Aug 29. doi: 10.1158/2326-6066.CIR-25-0083. Online ahead of print. ABSTRACT Polymerase epsilon mutant (POLE-mut) endometrial cancers (EC) are characterized by a near 100% disease-specific survival rate, even when treated by surgery alone. This spectacular survival, combined with the ultramutated genome and high level of neoantigens in these tumors, indicates a substantial degree … Read more
Cancer Immunol Res. 2025 Aug 29. doi: 10.1158/2326-6066.CIR-25-0047. Online ahead of print. ABSTRACT Immunotherapy has emerged as a promising treatment for head and neck squamous cell carcinoma (HNSCC), yet clinical responses remain limited. Elevated expression of interferon-stimulated gene 15 (ISG15), commonly observed in oral squamous cell carcinoma (OSCC), may contribute to this limited efficacy. Although … Read more
J Leukoc Biol. 2025 Aug 29:qiaf123. doi: 10.1093/jleuko/qiaf123. Online ahead of print. ABSTRACT Trained immunity amplifies innate immune responses in an antigen-independent manner. This study explored the ability of trained human primary macrophages to modulate the phenotype and function of T cells. Macrophages play an important role in antigen presentation, resulting in T-cell activation and … Read more
J Immunol. 2025 Aug 1;214(8):1881-1888. doi: 10.1093/jimmun/vkaf128. ABSTRACT Programmed cell death is an integral arm of immunity, especially in response to intracellular pathogen infection, for the release of inflammatory mediators, and the clearance of pathogen-infected cells. In the central nervous system, cell death as a form of immunity may seem paradoxical; neuronal health is critical … Read more
J Immunol. 2025 Aug 1;214(8):1863-1871. doi: 10.1093/jimmun/vkaf116. ABSTRACT The lymphatics are a system of vessels that traffic lymph and immune cells throughout the body to maintain fluid balance and aid in the response to infection and injury. Although the lymphatics are often thought of as a passive conduit, this review will demonstrate that the lymphatics … Read more
J Leukoc Biol. 2025 Aug 5;117(8):qiaf115. doi: 10.1093/jleuko/qiaf115. ABSTRACT We present a novel classification system for murine thymic epithelial cells (TECs), identifying 11 distinct types, four in the thymic cortex and seven in the medulla, based on their spatial localization and unique ultrastructural features. As key stromal components of the thymic microenvironment, TECs play indispensable … Read more
Nature Reviews Immunology, Published online: 29 August 2025; doi:10.1038/s41577-025-01220-yA study by Bhattarai et al. in Nature Immunology reports that ILC3-to-ILC1 plasticity in the gut is regulated by circadian clock proteins.
Cellular & Molecular Immunology, Published online: 29 August 2025; doi:10.1038/s41423-025-01338-yMacrophage-derived VISTA engages with LRIG1 and hinders gut epithelial repair in colitis
Cellular & Molecular Immunology, Published online: 29 August 2025; doi:10.1038/s41423-025-01337-zFunctional importance of bile acid-FXR signaling in neonatal immunity and disease
J Leukoc Biol. 2025 Aug 5;117(8):qiaf112. doi: 10.1093/jleuko/qiaf112. ABSTRACT Bronchopulmonary dysplasia (BPD) is the most common chronic lung disease in preterm infants and is a major health hazard for preterm infants worldwide. Hyperoxia-induced oxidative stress is one of the major risk factors for the development of BPD, and ideas for timely intervention in the development … Read more
J Immunol. 2025 Aug 28:vkaf208. doi: 10.1093/jimmun/vkaf208. Online ahead of print. ABSTRACT The main limitations of cancer treatment with high doses of recombinant interleukin 2 (IL-2) are high toxicity and the undesired expansion of regulatory T cells. The generation of IL-2 mutated variants (muteins) with changes in the affinity for different chains of the IL-2 … Read more
Chronic pain is a defining feature of endometriosis and contributes significantly to the diminished quality of life observed in affected individuals. Despite advances in understanding disease pathology, current therapeutic strategies largely fail to si…
IntroductionAnti-interferon-γ autoantibodies (AIGAs) syndrome is a rare, adult-onset immunodeficiency characterized by increased susceptibility to various opportunistic infections. Currently, there are no standardized diagnostic or therapeutic guidelin…
BackgroundIn recent years, an increasing number of studies have investigated the effects of breathing exercises on walking ability and quality of life in patients with multiple sclerosis (MS). However, the results of these studies are inconsistent. Thi…
Oral squamous cell carcinoma (OSCC) remains a formidable malignancy with persistently poor clinical outcomes. Recent research has underscored the pivotal role of the innate immune system, particularly tumor-associated macrophages (TAMs), a key componen…
Hepatic ischemia-reperfusion injury (HIRI) is a major complication in liver transplantation, hepatic surgeries, and shock-induced acute liver failure. This injury is characterized by mitochondrial dysfunction, oxidative stress, and calcium overload, wi…
Immune system plays a central role in the pathogenesis of cancer and autoimmune diseases. An entire field has emerged to identify separate minor cell subpopulations carrying potential molecular targets or activation markers to study their prognostic ro…
BackgroundThere is a lack in reliable and widely used prognostic scores to predict survival in patients with hepatocellular carcinoma (HCC) receiving immunotherapy. The aim of our study was to develop a prognostic score that could predict 1-year OS in …
As an important livestock species, sheep exhibit remarkable environmental adaptability. Immunoglobulins, expressed by B cells, are among the most crucial effector molecules in adaptive immunity. However, systematic research on the structure and express…
BackgroundUterine leiomyosarcoma (ULSA) is a highly aggressive gynecologic malignancy characterized by early metastasis, profound immunosuppression, and resistance to conventional therapies, including immune checkpoint blockade (ICB). The intricate tum…
BackgroundDistinguishing malignant lung adenocarcinoma (LAC) from benign pulmonary nodules (BPN) is a major clinical challenge. While exosomal microRNAs (miRNAs) are established liquid biopsy biomarkers, tumor-educated platelet miRNAs represent an emer…
Please confirm that the below Frontiers AI generated Alt-Text is an accurate visual description of your Figure(s). These Figure Alt-text proposals won’t replace your figure captions and will not be visible on your article. If you wish to make any chang…
The tumour microenvironment (TME) is a complex and dynamic environment containing diverse cellular, stromal and soluble factors, that collectively influence cancer progression, immune evasion and therapeutic resistance. Among the immune components of t…
BackgroundDiabetic nephropathy (DN), a major complication of type 2 diabetes mellitus (DM), is driven by complex mechanisms involving mitochondrial dysfunction, senescence, and chronic inflammation. Despite therapeutic advances, interventions specifica…
BackgroundHypertrophic spinal pachymeningitis (HSP) and retroperitoneal fibrosis (RPF) are rare inflammatory disorders, often associated with immunoglobulin G4-related disease (IgG4-RD). This case underscores the diagnostic intricacies and therapeutic …
BackgroundThe prognosis of kidney transplantation is currently assessed primarily through clinical monitoring, which involves considerable time and financial costs. Estimated plasma volume status (ePVS) has emerged as a straightforward and efficient me…
IntroductionHyperactivation of the Wnt/β-catenin pathway serves as a central mechanism underlying tumor progression, immune evasion, and resistance to immune checkpoint inhibitor therapy in colorectal cancer (CRC). A pivotal contributor to this process…
BackgroundThe current study evaluated the impact of lysophospholipid emulsifiers’ (LPLs) dietary incorporation on ameliorating the negative impacts of oxidative stress in broilers.MethodsA total of 270 2-week-old male Avian 48 chicks were randomly divi…
BackgroundAlthough precision-targeted therapies and tyrosine kinase inhibitors (TKIs) have significantly improved outcomes in non-small-cell lung cancer (NSCLC), patients with EGFR-mutant NSCLC with concurrent TP53 mutations often develop drug resistan…
Ulcerative colitis (UC) is a kind of chronic inflammatory bowel disease, is driven by dysregulated immune responses involving neutrophils (NEUs) and macrophages. NEUs exacerbate mucosal injury through reactive oxygen species (ROS), neutrophil extracell…
Regulatory T cells (Tregs) are a unique subset of T cells vital for maintaining immune balance, preventing autoimmune diseases, and controlling immune responses. First identified in the early 1990s, Tregs are now well recognized for their role in suppr…
Although initially described as an immune-privileged site, the central nervous system (CNS) is now known to harbor a resident immune system, composed of different innate and adaptive cell types that maintain tissue homeostasis, are regulated in patholo…
IntroductionHepatocellular carcinoma (HCC) represents a significant health challenge, with immunotherapy serving as a crucial component of its complex treatment regimen. This study investigates the use of TP53Y220C as a preferred antigen to induce cyto…
Herpes simplex keratitis (HSK), caused by herpes simplex virus type I (HSV-1) ocular infection, is a leading cause of visual morbidity worldwide, and although cases of HSK can be managed with current medications, new developments are required to make t…
BackgroundThis study aimed to investigate ferroptosis-related biomarkers and their potential molecular basis in UC.MethodsUC datasets (GSE87466 and GSE47908) from the Gene Expression Omnibus database were merged as the training set, and batch effects w…
The tumor microenvironment (TME) is a complex system, in which the energy metabolism of tumor cells plays a key role in the occurrence, development and metastasis of tumors. In the TME, the energy supply of tumor cells mainly comes from glycolysis. Thi…
BackgroundImmunotherapy has progressively gained prominence as a cornerstone therapeutic modality across diverse oncological contexts, with its clinical efficacy intricately linked to the dynamic interactions between the tumor microenvironment (TME) an…
BackgroundPrimary cicatricial alopecia (PCA) is known to be associated with various comorbidities; however, findings regarding the likelihood of specific comorbidities in PCA patients have been inconsistent.ObjectiveThis study aimed to assess the preva…
ObjectiveIn this study, we retrospectively analyzed the relationship between PRL level and serum inflammatory and immune markers in patients with granulomatous lobular mastitis (GLM) and analyzed the effect of bromocriptine treatment on serum inflammat…
Cancer Immunol Res. 2025 Aug 28. doi: 10.1158/2326-6066.CIR-25-0159. Online ahead of print. ABSTRACT Myeloid cells – including monocytes, macrophages, dendritic cells, and granulocytes – are critical architects of the tumor microenvironment, where they exert diverse functions ranging from immunosuppressive to immunostimulatory. Advances in single-cell omics and high-dimensional immune profiling have unveiled the remarkable heterogeneity and … Read more
Cancer Immunol Res. 2025 Aug 28. doi: 10.1158/2326-6066.CIR-25-0491. Online ahead of print. ABSTRACT Advanced sarcomas have limited treatment options after standard therapy, and therefore we investigated the efficacy and safety of sintilimab plus anlotinib in this setting. Patients aged 18-75 years with advanced sarcomas and prior systemic therapy were enrolled. Patients with untreated, primary chemotherapy-resistant … Read more
Cancer Immunol Res. 2025 Aug 28. doi: 10.1158/2326-6066.CIR-24-0835. Online ahead of print. ABSTRACT While immune checkpoint inhibitors have led to durable responses in various cancer types, a substantial proportion of patients do not respond to these interventions. To uncover potential factors associated with a positive response to immunotherapy, we used a bilateral tumor model using … Read more
Curr Opin Immunol. 2025 Aug 26;96:102649. doi: 10.1016/j.coi.2025.102649. Online ahead of print. ABSTRACT Acute graft-versus-host disease (aGVHD) is a significant complication of allogeneic hematopoietic cell transplantation (allo-HCT), characterized by immune-mediated tissue damage from donor immune cells. Standard treatment of aGVHD involves systemic corticosteroids, but many patients do not respond adequately, with 30%-50% of patients being … Read more
J Immunol. 2025 Aug 28:vkaf177. doi: 10.1093/jimmun/vkaf177. Online ahead of print. ABSTRACT Identifying cell intrinsic regulators of immune sexual dimorphism is critical for treatment of several immunopathologies. We show that Malat1 is required for appropriate cytokine expression in female but not male T helper 2 (Th2) cells. Malat1 deficiency impairs in vitro Th2 differentiation of … Read more
Curr Opin Immunol. 2025 Aug 26;96:102650. doi: 10.1016/j.coi.2025.102650. Online ahead of print. ABSTRACT Transfusion-related acute lung injury (TRALI) is a life-threatening complication of blood transfusion, with mortality rates exceeding 40% in critically ill patients. Despite its clinical severity, TRALI pathogenesis remains unclear, leaving clinicians struggling to fully understand and manage it due to its unpredictable … Read more
Trends Immunol. 2025 Aug 26:S1471-4906(25)00200-5. doi: 10.1016/j.it.2025.08.002. Online ahead of print. ABSTRACT Gut dysbiosis and intestinal inflammation may contribute to neurological disorders through the gut-brain axis. A recent report by White et al. uncovered that intestinal inflammation triggers the migration of microbiota-specific CD4+ T cells to the brain, where they drive neuroinflammatory responses via IL-23R/GM-CSF. … Read more
BackgroundThe tumor microenvironment (TME) is crucial in influencing the progression and therapeutic response of ovarian cancer.MethodThis study conducted a comprehensive bibliometric and visualization analysis of research trends and focal areas concer…
BackgroundMalate dehydrogenase 1 (MDH1), an NAD(H)-dependent isoenzyme, is a key component of the malate-aspartate shuttle (MAS). A significant association has been observed between MDH1 expression and various characteristics of the tumor microenvironm…
