- Reaching maturity: Thymic γδ T cell differentiation in mice and humans
by Rúben G. R. Pinheiro and Bruno Silva-Santos
Science Immunology, Volume 10, Issue 114, December 2025.
- Erratum for the Review “The immunology of brain tumors” by L. Bunse et al.
by AAAS: Science Immunology: Table of Contents
Science Immunology, Volume 10, Issue 114, December 2025.
- Heterogeneity of the intestinal mononuclear phagocyte compartment in health and inflammatory bowel disease
by inmunoadmin
Science Immunology, Volume 10, Issue 114, December 2025.
- Hypoxia-induced EGR1 remodels neutrophils to suppress antitumor immunity
by inmunoadmin
Science Immunology, Volume 10, Issue 114, December 2025.
- Smart chains: Designer antibodies shaped by AI
by Thomas T. Xu and Shiv Pillainn
Science Immunology, Volume 10, Issue 114, December 2025.
- Sugar-coated CAR T for sweeter cell therapies
by Dachuan Dong and Jonathan S. Maltzman
Science Immunology, Volume 10, Issue 114, December 2025.
- Assessing AI’s cognitive abilities for scientific discovery in the field of systems vaccinology
by Lucie Rodriguez-Coffinet, Dmitri Kazmin, Bali Pulendran
Science Immunology, Volume 10, Issue 114, December 2025.
- AI immunologists are here: Are they ready for prime time?
by Jacob Kim, Ao Huang, John S. Tsang
Science Immunology, Volume 10, Issue 114, December 2025.
- Molecular basis for de novo thymus regeneration in a vertebrate, the axolotl
by inmunoadmin
Science Immunology, Volume 10, Issue 114, December 2025.
- Maternal allergy and neonatal RSV infection synergize via FcR-mediated allergen uptake to promote the development of asthma in early life
by inmunoadmin
Science Immunology, Volume 10, Issue 113, November 2025.
- Editorial expression of concern
by Seth Thomas Scanlon
Science Immunology, Volume 10, Issue 113, November 2025.
- Joint profiling of gene expression and chromatin accessibility in pancreatic lymph nodes and spleens in human type 1 diabetes
by inmunoadmin
Science Immunology, Volume 10, Issue 113, November 2025.
- GPR25 promotes the formation of lung and liver tissue-resident memory CD8 T cells
by inmunoadmin
Science Immunology, Volume 10, Issue 113, November 2025.
- An islet-resident macrophage antioxidant program preserves β cell physiology
by inmunoadmin
Science Immunology, Volume 10, Issue 113, November 2025.
- CD21 primes extrafollicular differentiation of autoreactive B cells in a TLR7-driven lupus model
by inmunoadmin
Science Immunology, Volume 10, Issue 113, November 2025.
- Two of a kind, one with MS: Gut microbes tip the balance
by Kevin Champagne-Jorgensen and Jennifer L. Gommerman
Science Immunology, Volume 10, Issue 113, November 2025.
- B cells and dengue: A cat-and-mouse game
by Kritika Dixit and David R. Martinez
Science Immunology, Volume 10, Issue 113, November 2025.
- Characterization of the mammalian prodefinitive angio-hematopoietic lineage
by inmunoadmin
Science Immunology, Volume 10, Issue 113, November 2025.
- B cells targeting parasites capture spatially linked antigens to secure T cell help
by inmunoadmin
Science Immunology, Volume 10, Issue 113, November 2025.
- TH17 cells converted into exTH17 cells sustain rheumatoid-like IL-17–independent inflammatory arthritis
by inmunoadmin
Science Immunology, Volume 10, Issue 113, November 2025.
- Stem-like tissue-resident memory T cells control functional heterogeneity and reactivation of T cell memory in the intestine
by inmunoadmin
Science Immunology, Volume 10, Issue 112, October 2025.
- Local activation of mutant RIG-I by short noncoding Y-RNA in the kidney triggers lethal nephritis
by inmunoadmin
Science Immunology, Volume 10, Issue 112, October 2025.
- RNA binding proteins control the G2-M checkpoint of the germinal center B cell
by inmunoadmin
Science Immunology, Volume 10, Issue 112, October 2025.
- Mitochondrial and lysosomal signaling orchestrates heterogeneous metabolic states of regulatory T cells
by inmunoadmin
Science Immunology, Volume 10, Issue 112, October 2025.
- Lipolysis-microlipophagy cascade regulated by adipose triglyceride lipase drives pathogenic adaptive type 2 immunity
by inmunoadmin
Science Immunology, Volume 10, Issue 112, October 2025.
- Simultaneous induction of multiple classes of broadly neutralizing antibody precursors by combination germline-targeting immunization in nonhuman primates
by inmunoadmin
Science Immunology, Volume 10, Issue 112, October 2025.
- Simultaneous priming of HIV broadly neutralizing antibody precursors to multiple epitopes by germline-targeting mRNA-LNP immunogens in mouse models
by inmunoadmin
Science Immunology, Volume 10, Issue 112, October 2025.
- Protein palmitoylation and sphingolipid metabolism control regulated exocytosis in cytotoxic lymphocytes
by inmunoadmin
Science Immunology, Volume 10, Issue 112, October 2025.
- Anticancer immune responses are hindered by cis interaction of inhibitory checkpoint SIRPα
by inmunoadmin
Science Immunology, Volume 10, Issue 112, October 2025.
- Erratum for the Research Article “METTL1-mediated m7G methylation of Sarm1 mRNA promotes macrophage inflammatory responses and multiple organ injury” by C. Hou et al.
by AAAS: Science Immunology: Table of Contents
Science Immunology, Volume 10, Issue 112, October 2025.
- Germinal center–mediated broadening of B cell responses to SARS-CoV-2 booster immunization
by inmunoadmin
Science Immunology, Volume 10, Issue 112, October 2025.
- Taking aim at autoimmunity—Antigen-Fc constructs for mucosal pemphigus hit the mark
by Francesca Beretta and Valentina Damato
Science Immunology, Volume 10, Issue 112, October 2025.
- The immunology of brain tumors
by Lukas Bunse, Theresa Bunse, Michael Kilian, Francisco J. Quintana, Michael Platten
Science Immunology, Volume 10, Issue 112, October 2025.
- The power of the few: RORγt+ dendritic cells promote food-specific peripheral regulatory T cells
by Elise G. Liu and Adam Williams
Science Immunology, Volume 10, Issue 112, October 2025.
- Vaccination-induced T cell responses maintain polyclonality with high antigen receptor avidity
by inmunoadmin
Science Immunology, Volume 10, Issue 112, October 2025.
- Group 2 innate lymphoid cells regulate nociceptive and gait functions of the peripheral nervous system
by inmunoadmin
Science Immunology, Volume 10, Issue 111, September 2025.
- Design of a potent interleukin-21 mimic for cancer immunotherapy
by inmunoadmin
Science Immunology, Volume 10, Issue 111, September 2025.
- Inhibitory immune checkpoints in cancer immunotherapy
by Zhenghai Tang and André Veillette
Science Immunology, Volume 10, Issue 111, September 2025.
- Nuclear polarization to the immune synapse facilitates an early transcriptional burst
by inmunoadmin
Science Immunology, Volume 10, Issue 111, September 2025.
- Allergen-induced airway matrix remodeling in mice can be prevented or reversed by targeting chitinase-like proteins
by inmunoadmin
Science Immunology, Volume 10, Issue 111, September 2025.
- Single-cell multiomics identifies Tcf1 and Lef1 as key initiators of early thymic progenitor fate
by inmunoadmin
Science Immunology, Volume 10, Issue 111, September 2025.
- Loss-of-function mutations ensure that response to immune checkpoint therapy is NOD2 be denied
by Ana C. Anderson and Manu Rangachari
Science Immunology, Volume 10, Issue 111, September 2025.
- It’s getting hot in here: Heating up the tumor microenvironment with an oral HO-1 inhibitor
by Cait A. McAlindon and Rachael A. Clark
Science Immunology, Volume 10, Issue 111, September 2025.
- METTL1-mediated m7G methylation of Sarm1 mRNA promotes macrophage inflammatory responses and multiple organ injury
by inmunoadmin
Science Immunology, Volume 10, Issue 111, September 2025.
- Enkephalin-producing regulatory T cells in the skin restrain local inflammation through control of nociception
by inmunoadmin
Science Immunology, Volume 10, Issue 111, September 2025.
- DDX55 safeguards naïve T cell homeostasis by suppressing activation-promoting transposable elements
by inmunoadmin
Science Immunology, Volume 10, Issue 111, September 2025.
- Dosing interval is a major factor determining the quality of T cells induced by SARS-CoV-2 mRNA and adenoviral vector vaccines
by inmunoadmin
Science Immunology, Volume 10, Issue 110, August 2025.
- MAIT and other innate-like T cells integrate adaptive immune responses to modulate interval-dependent reactogenicity to mRNA vaccines
by inmunoadmin
Science Immunology, Volume 10, Issue 110, August 2025.
- Reprogramming intratumoral Treg cells by morpholino-mediated splicing of FOXP3 for cancer immunotherapy
by inmunoadmin
Science Immunology, Volume 10, Issue 110, August 2025.
- HIV broadly neutralizing antibody precursors to the Apex epitope induced in nonhuman primates
by inmunoadmin
Science Immunology, Volume 10, Issue 110, August 2025.
- Combined Flt3L and CD40 agonism restores dendritic cell–driven T cell immunity in pancreatic cancer
by inmunoadmin
Science Immunology, Volume 10, Issue 110, August 2025.
- COVID-19 vaccine type controls stromal reprogramming in draining lymph nodes
by inmunoadmin
Science Immunology, Volume 10, Issue 110, August 2025.
- Stem-like and effector peripheral helper T cells comprise distinct subsets in rheumatoid arthritis
by inmunoadmin
Science Immunology, Volume 10, Issue 110, August 2025.
- Erratum for the Research Article “Targeting T cell plasticity in kidney and gut inflammation by pooled single-cell CRISPR screening” by L. U. B. Enk et al.
by AAAS: Science Immunology: Table of Contents
Science Immunology, Volume 10, Issue 110, August 2025.
- GM-CSF derived from alveolar type 2 cells promotes CD301b+ cDC2 generation and allergic airway inflammation
by inmunoadmin
Science Immunology, Volume 10, Issue 110, August 2025.
- A noncanonical cytoplasmic role for BUB1 in restraining DNA damage–induced dsRNA accumulation and sensing within stress granules
by Mengjie Hu, Dong Pan, Meng Jiao, Xuhui Bao, Xinjian Liu, Fang Li, Chuan-Yuan Li
Science Immunology, Volume 10, Issue 110, August 2025.
- A LAGging kiss leaves T cells cold
by Thomas T. Xu and Shiv Pillainn
Science Immunology, Volume 10, Issue 110, August 2025.
- Immune signature clues are key to unlocking the mystery of clinical responses
by Robin R. Kobylski and Laura A. Solt
Science Immunology, Volume 10, Issue 110, August 2025.
- Vagal TRPV1+ sensory neurons protect against influenza virus infection by regulating lung myeloid cell dynamics
by inmunoadmin
Science Immunology, Volume 10, Issue 110, August 2025.
- CD4 T cell therapy counteracts inflammaging and senescence by preserving gut barrier integrity
by inmunoadmin
Science Immunology, Volume 10, Issue 110, August 2025.
- Human CD4+ T cells regulate peripheral immune responses in rheumatoid arthritis via insulin-like growth factor–like family member 2
by inmunoadmin
Science Immunology, Volume 10, Issue 110, August 2025.
- A Dock8-dependent mechanosensitive central actin pool maintains T cell shape and protects the nucleus during migration
by inmunoadmin
Science Immunology, Volume 10, Issue 109, July 2025.
- Regulatory T cells in brown adipose tissue safeguard thermogenesis by restraining interferon-γ–producing lymphocytes
by inmunoadmin
Science Immunology, Volume 10, Issue 109, July 2025.
- Tissue origin and virus specificity shape human CD8+ T cell cytotoxicity
by inmunoadmin
Science Immunology, Volume 10, Issue 109, July 2025.
- OTUD3 prevents ulcerative colitis by inhibiting microbiota-mediated STING activation
by inmunoadmin
Science Immunology, Volume 10, Issue 109, July 2025.
- Interactions between placental Hofbauer cells and L. monocytogenes change throughout gestation
by inmunoadmin
Science Immunology, Volume 10, Issue 109, July 2025.
- Innate lymphoid cells originate from fetal liver–derived tissue-resident progenitors
by inmunoadmin
Science Immunology, Volume 10, Issue 109, July 2025.
- Multimodal delineation of a layer of effector function among exhausted CD8 T cells in tumors
by inmunoadmin
Science Immunology, Volume 10, Issue 109, July 2025.
- Noncanonical Hedgehog signaling through Smoothened controls cytotoxic T cell migration in the tumor microenvironment
by inmunoadmin
Science Immunology, Volume 10, Issue 109, July 2025.
- TB or not TB: That depends on the antibody Fc
by Surabhi Kumar and Kevin C. O’Connor
Science Immunology, Volume 10, Issue 109, July 2025.
- Tuft cells restrain intestinal type 2 immunity through the transcription factor Spi-B
by inmunoadmin
Science Immunology, Volume 10, Issue 109, July 2025.
- The 10 commandments of immunoregulation in lymphoma
by Maria de los Reyes Capilla Guerra and Gabriel K. Griffin
Science Immunology, Volume 10, Issue 109, July 2025.
- Primate retroelement exonization and sexually dimorphic IL13RA1 transcription tune type 2 immune responses
by inmunoadmin
Science Immunology, Volume 10, Issue 109, July 2025.
- Radiotherapy enhances anticancer CD8 T cell responses by cGAMP transfer through LRRC8A/C volume-regulated anion channels
by inmunoadmin
Science Immunology, Volume 10, Issue 108, June 2025.
- Riplet promotes lipid metabolism changes associated with CD8 T cell exhaustion and anti–PD-1 resistance in hepatocellular carcinoma
by inmunoadmin
Science Immunology, Volume 10, Issue 108, June 2025.
- CLNS1A regulates genome stability and cell cycle progression to control CD4 T cell function and autoimmunity
by inmunoadmin
Science Immunology, Volume 10, Issue 108, June 2025.
- A linear ontogeny accounts for the development of naive, memory, and tumor-infiltrating regulatory T cells in mice
by inmunoadmin
Science Immunology, Volume 10, Issue 108, June 2025.
- TNF switches homeostatic efferocytosis to lytic caspase-8–dependent pyroptosis and IL-1β maturation
by inmunoadmin
Science Immunology, Volume 10, Issue 108, June 2025.
- Noncanonical functions of T follicular helper cells
by Shivangi Dave and André Ballesteros-Tato
Science Immunology, Volume 10, Issue 108, June 2025.
- PSGL-1 is a phagocytosis checkpoint that enables tumor escape from macrophage clearance
by inmunoadmin
Science Immunology, Volume 10, Issue 108, June 2025.
- Inflammatory mischief managed: How retinoic acid calms heart attacks at the (marrow) source
by Sahily Reyes-Esteves and Christopher A. Hunter
Science Immunology, Volume 10, Issue 108, June 2025.
- An Il12 mRNA-LNP adjuvant enhances mRNA vaccine–induced CD8 T cell responses
by inmunoadmin
Science Immunology, Volume 10, Issue 108, June 2025.
- Dissection of the immune landscape in psoriatic arthritis defines immunoproteasome up-regulation in treatment resistance
by inmunoadmin
Science Immunology, Volume 10, Issue 108, June 2025.
- Inducible protein degradation reveals inflammation-dependent function of the Treg cell lineage–defining transcription factor Foxp3
by inmunoadmin
Science Immunology, Volume 10, Issue 108, June 2025.
- Immuno-amnesia: Without B cells, T cells cannot remember
by Jonathan S. Maltzmannnn
Science Immunology, Volume 10, Issue 108, June 2025.
- An activating Stat1 mutant disrupts normal STAT4 innate lymphocyte programs during viral infection
by inmunoadmin
Science Immunology, Volume 10, Issue 107, May 2025.
- Human LY9 governs CD4+ T cell IFN-γ immunity to Mycobacterium tuberculosis
by inmunoadmin
Science Immunology, Volume 10, Issue 107, May 2025.
- A light-regulated circadian timer optimizes neutrophil bactericidal activity to boost daytime immunity
by inmunoadmin
Science Immunology, Volume 10, Issue 107, May 2025.
- An engineered viral protein activates STAT5 to prevent T cell suppression
by inmunoadmin
Science Immunology, Volume 10, Issue 107, May 2025.
- ILC3s promote intestinal tuft cell hyperplasia and anthelmintic immunity through RANK signaling
by inmunoadmin
Science Immunology, Volume 10, Issue 107, May 2025.
- Cross-regulation between the nervous system and type 2 immunity
by Nicholas M. Mroz, Pailin Chiaranunt, Anna V. Molofsky, Ari B. Molofsky
Science Immunology, Volume 10, Issue 107, May 2025.
- C/EBPα activates Irf8 expression in myeloid progenitors at the +56-kb enhancer to initiate cDC1 development
by inmunoadmin
Science Immunology, Volume 10, Issue 107, May 2025.
- Uptake of lipids from ascites drives NK cell metabolic dysfunction in ovarian cancer
by inmunoadmin
Science Immunology, Volume 10, Issue 107, May 2025.
- Chimeric autoantibody receptor T cells clonally eliminate B cells producing autoantibodies against IFN-γ
by inmunoadmin
Science Immunology, Volume 10, Issue 107, May 2025.
- How dengue defies dogma: An extrafollicular tale
by Jordan Polster and David R. Martinez
Science Immunology, Volume 10, Issue 107, May 2025.
- Tolerance requires diversity (of antigen presenting cells)
by Danielle R. Jacobsen and Stephanie C. Eisenbarth
Science Immunology, Volume 10, Issue 107, May 2025.
- Apoptotic cells are not all created equal
by Amanda O. Wong and Kodi S. Ravichandran
Science Immunology, Volume 10, Issue 107, May 2025.
- Distinct type I and II interferon responses direct cortical and medullary thymic epithelial cell development
by inmunoadmin
Science Immunology, Volume 10, Issue 107, May 2025.
- Fibroblastic reticular cells form reactive myeloid cell niches in human lymph nodes
by inmunoadmin
Science Immunology, Volume 10, Issue 107, May 2025.
- Cell type–specific efferocytosis determines functional plasticity of alveolar macrophages
by inmunoadmin
Science Immunology, Volume 10, Issue 107, May 2025.
