- CCNE1 overexpression drives a cGAS-STING-dependent interferon response and sensitizes HRD-positive ovarian cancer to immune checkpoint blockadeby Wang, X., Chen, T., Wang, Z., Wang, C., Xu, X., Yang, M., Zhang, G., Huang, Y., Liu, H.
- Plasma cell-free RNA ITGB3 is associated with long-term clinical benefit in patients with non-small cell lung cancer receiving immunochemotherapyby Yu, Y., Liu, Y., Zhang, X., Yang, W., Hou, S., Yu, W., Zhang, F., Yu, B., Hu, Z., Wu, Z., Huang, S., Wang, J.
- Ptpn1 deficiency collaborates with a NUP98::HOXD13 fusion gene to generate B cell precursor acute lymphoblastic leukemiaby inmunoadminJ Immunol. 2026 Oct 1;215(10):vkag250. doi: 10.1093/jimmun/vkag250. ABSTRACT B cell precursor acute lymphoblastic leukemia (BCP ALL) is driven by a combination of genetic alterations that promote invasion and expansion of undifferentiated B cells. Mice that express a NUP98::HOXD13 (NHD13) fusion gene in hematopoietic cells develop a wide range of hematologic malignancy, and when crossed to … Read more
- Plasma metabolomic profiling identifies candidate biomarkers associated with sepsis diagnosis and mortality predictionby Yanyan ZhuIntroductionSepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection; its early diagnosis and mortality prediction remain challenging, and conventional markers (CRP, PCT) have limited sensitivity and specificit…
- Integrative transcriptomic and computational analysis associates Ms4a6c+ macrophages with fibrosis in radiation proctitis and computationally nominates MOTS-c as a candidate modulatorby Peng WangBackgroundChronic radiation proctitis (CRP) represents a significant clinical challenge characterized by irreversible fibrosis and a lack of specific pharmacological interventions. This study aimed to elucidate the cellular mechanisms underlying impair…