- CD39+CD71+ erythroid cells exhibit enhanced purine metabolism and T cell-suppressive function in triple-negative breast cancer and other immunoregulatory settingsby inmunoadminJ Immunol. 2026 Nov 2;215(11):vkag301. doi: 10.1093/jimmun/vkag301. ABSTRACT CD71+ erythroid cells (CECs) expand in tumor-bearing hosts and suppress antitumor immunity, but the mechanisms underlying their immunoregulatory activity remain incompletely understood. Here, we identify CD39-mediated purine metabolism as a previously unrecognized suppressive pathway used by CECs. In the 4T1 model of triple-negative breast cancer, CD39 was … Read more
- Dendritic cell metabolism in cancer and immunityby Zhiyuan YouNature Reviews Immunology, Published online: 13 November 2026; doi:10.1038/s41577-026-01368-1This Review explores how nutrients, metabolites and metabolic programmes shape the immunogenic and tolerogenic functions of dendritic cells (D…
- TOX and PD-1 are required for the maintenance of CD4 T cell precursors during chronic infectionScience Immunology, Volume 11, Issue 125, November 2026.
- IFN-γ–driven MHC class II on gut epithelium induces cytolytic TH1 cell differentiation and stem cell loss in graft-versus-host diseaseScience Immunology, Volume 11, Issue 125, November 2026.
- The development and validation of an IL-1β fate-mapping mouse unveils unexpected heterogeneity in innate immunityby inmunoadminJ Immunol. 2026 Nov 2;215(11):vkag304. doi: 10.1093/jimmun/vkag304. ABSTRACT Interleukin-1 beta (IL-1β) is a highly proinflammatory cytokine whose synthesis and cleavage are tightly regulated. It is important for protection from several infections, but can also play a damaging role in autoimmune and autoinflammatory diseases. While pattern recognition receptor activation leads to potent induction of IL-1β, its … Read more