- Multimodal and fair artificial intelligence in paediatric rheumatology: challenges and opportunities for a holistic and equitable futureby inmunoadminCurr Opin Immunol. 2026 Aug 14;102:102835. doi: 10.1016/j.coi.2026.102835. Online ahead of print. ABSTRACT Multimodal artificial intelligence (AI) is an emerging domain comprising a set of tools with potential clinical relevance in paediatric rheumatology, a field characterised by rare, heterogeneous diseases and diagnostic delays. This narrative review synthesises current evidence on how multimodal and fair AI … Read more
- Generation and characterization of a novel MHC-II tetramer for tracking and characterization of toxin B-specific CD4+ T cell responsesby inmunoadminJ Immunol. 2026 Aug 4;215(8):vkag152. doi: 10.1093/jimmun/vkag152. ABSTRACT The gastrointestinal pathogen Clostridioides difficile is a major burden for health systems due to high rates of recurrence. C. difficile pathogenesis is mediated by two virulence factors, toxin A (TcdA) and toxin B (TcdB). Antibodies specific for TcdA and TcdB are correlated with protection from symptomatic recurrence; … Read more
- One lipid to imprint them all?. Nicolas Cénacby inmunoadminTrends Immunol. 2026 Aug 14:S1471-4906(26)00188-2. doi: 10.1016/j.it.2026.07.009. Online ahead of print. ABSTRACT A recent report by Fan et al. identifies trans-vaccenic acid, a maternal diet-derived lipid transferred through breast milk, as a key regulator of neonatal T-cell development. Beyond identifying a single bioactive metabolite, this study positions breast milk as a source of developmental signals … Read more
- The transcription factor NF-Y promotes myeloid cell survival and protects from inflammatory vascular diseaseCarlos Silvestre-Roig on 14 de August de 2026 at 10:00by inmunoadminJ Leukoc Biol. 2026 Aug 14:qiag113. doi: 10.1093/jleuko/qiag113. Online ahead of print. ABSTRACT Myeloid cells orchestrate vascular inflammation through transcriptional programs that control their maturation, effector function, and survival. While lineage-determining transcription factors establish myeloid identity, our understanding of the transcriptional regulation of myeloid cell behavior in chronic inflammatory contexts remains limited. Nuclear factor-Y (NF-Y) … Read more
- TIM3 blockade with hypomethylating therapy restores NK-cell and cytotoxic CD4+ T-cell activity in patients with AML or MDSby inmunoadminCancer Immunol Res. 2026 Aug 14. doi: 10.1158/2326-6066.CIR-26-0160. Online ahead of print. ABSTRACT Occasional complete responses to immune checkpoint inhibitor therapy demonstrate that acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) can be immune-sensitive when appropriately targeted. Here, we analyzed AML/MDS patients (n=14) treated with the anti-TIM3 sabatolimab and the hypomethylating agent decitabine in a … Read more