- Secondary bile acids as immune and metabolic mediators. Stefano Fiorucciby inmunoadminTrends Immunol. 2026 Mar 3:S1471-4906(25)00316-3. doi: 10.1016/j.it.2025.12.008. Online ahead of print. ABSTRACT Bile acids are cholesterol derivatives, generated by the coordinated intervention of human and bacterial genes, functioning as endogenous ligands for multiple transcription factors and receptors throughout the body. While only two primary bile acids are generated by the human liver, the intestinal microbiota … Read more
- Amyloid precursor protein is a subunit of microglial Hv1 channelsby inmunoadminCurr Opin Immunol. 2026 Mar 3;100:102751. doi: 10.1016/j.coi.2026.102751. Online ahead of print. ABSTRACT Voltage-gated proton channels (Hv1) are key regulators of microglial activation, coupling proton extrusion to reactive oxygen species production, cellular pH homeostasis, and pro-inflammatory signaling. Dysregulated Hv1 activity exacerbates neuroinflammation and contributes to a range of central nervous system pathologies. Our recent work … Read more
- Clinical trials and new therapies in Sjögren’s diseaseby inmunoadminCurr Opin Immunol. 2026 Mar 3;100:102743. doi: 10.1016/j.coi.2026.102743. Online ahead of print. ABSTRACT Despite major advances in understanding Sjögren’s disease (SjD), no approved disease-modifying therapies have been approved. Management remains largely symptomatic with the use of off-label immunomodulators for systemic features. This gap highlights the substantial unmet need for targeted treatment. Encouragingly, the therapeutic landscape … Read more
- Targeting synovial fibroblast KCa1.1 channels in rheumatoid arthritisby inmunoadminCurr Opin Immunol. 2026 Mar 3;100:102747. doi: 10.1016/j.coi.2026.102747. Online ahead of print. ABSTRACT Fibroblast-like synoviocytes (FLS) play major roles in the pathogenesis of rheumatoid arthritis (RA). Human and rat FLS express the KCa1.1 channel (BK, Maxi-K, Slo1, and KCNMA1) as their major potassium channel at the plasma membrane. Reducing the expression or function of this … Read more
- Beyond ion flux: the potassium channel KV1.3 and its regulatory function in neutrophilsby inmunoadminCurr Opin Immunol. 2026 Mar 3;100:102750. doi: 10.1016/j.coi.2026.102750. Online ahead of print. ABSTRACT The voltage-gated potassium channel KV1.3 (KCNA3) is a critical ion channel regulating membrane potential in immune cells, facilitating sustained calcium influx and activating downstream signaling events. Besides its canonical role as an ion channel, KV1.3 has been postulated to exert additional functions … Read more