- Lysosome-Induced Increase in Intracellular Granularity of Leukocytes: A Key Morphological Biomarker for Early Sepsis in Cell Population DataHuan Qi on 16 de July de 2026 at 10:00by inmunoadminJ Leukoc Biol. 2026 Jul 16:qiag098. doi: 10.1093/jleuko/qiag098. Online ahead of print. ABSTRACT Early and rapid identification of sepsis is critical for improving clinical outcomes; however, reliable real-time biomarkers remain unavailable. The scattergram parameters of peripheral blood circulating leukocytes are altered during infection and sepsis. This study aims to explore the cellular biological characteristics underlying … Read more
- A role for non-coding RNAs and alternative splicing in the regulation of neutrophil activation and gene expression in systemic lupus erythematosusGrace Filbertine on 16 de July de 2026 at 10:00by inmunoadminJ Leukoc Biol. 2026 Jul 16:qiag100. doi: 10.1093/jleuko/qiag100. Online ahead of print. ABSTRACT Excess neutrophil apoptosis and the release of neutrophil extracellular traps (NETs) in systemic lupus erythematosus (SLE) leads to accumulation of cell debris and production of auto-antibodies targeting nuclear proteins and DNA. SLE neutrophil activation is regulated by changes in gene expression, notably … Read more
- Blautia coccoides-derived acetate potentiates anti-PD-1 immunotherapy in melanoma by activating cytotoxic CD8+ T cellsby Zhang, Z., Liang, X., Tian, Y., Li, C., Cao, X., Wang, D., Xie, A., Liu, S., Lin, K., Li, Q., Liang, Y.Background Gut microbiota can modulate cancer immunotherapy and enhance the efficacy of programmed cell death protein 1 (PD-1) blockade in tumors, yet the responsible microbes and underlying mechanisms remain incompletely understood. Methods Publicly…
- Diverse origin and nature of tumor-infiltrating lymphocytes: the infection hypothesisby inmunoadminIn the 19th century, Rudolf Virchow observed lymphocyte infiltration in tumors and suggested a potential link between cancer and inflammation. Current explanations for the origin of tumor-infiltrating lymphocytes are based on the interaction between c…
- Interleukin-18 armours antitumour immune effectorsby Akshat SharmaNature Reviews Immunology, Published online: 16 July 2026; doi:10.1038/s41577-026-01330-1Interleukin-18 (IL-18) shapes tumour immunity through tightly regulated, context-dependent effects on T cells, NK cells and the tumour microenviro…