A drug dismantles a metabolic barrier to anti-tumor immunity
A new study has identified a specific mode of fat uptake by immune cells within tumors that serves as a metabolic checkpoint against anti-cancer immune responses.
Immune System News -- ScienceDaily
Are ‘zombie’ skin cells harmful or helpful? The answer may be in their shapes
Researchers have identified three subtypes of senescent skin cells with distinct shapes, biomarkers, and functions — an advance that could equip scientists with the ability to target and kill the harmful types while leaving the helpful ones intact.
New way to prevent duodenal cancer
People with the hereditary disease familial adenomatous polyposis (FAP) have a greatly increased risk of developing a malignant tumor of the duodenum. Researchers have now discovered a mechanism in the local immune system that can drive the development…
Immune cells drive congenital paralysis disease
Patients with spastic paraplegia type 15 develop movement disorders during adolescence that may ultimately require the use of a wheelchair. In the early stages of this rare hereditary disease the brain appears to play a major role by over-activating th…
Scientists develop new bone marrow imaging technique
A new bone marrow imaging technique could change treatment for cancer, autoimmune disease and musculoskeletal disorders.
Blocking a surprising master regulator of immunity eradicates liver tumors in mice
‘Cold’ tumors are resistant to common immunotherapies. Researchers have uncovered a master regulator that can be manipulated to prevent tumor growth in mice.
New bioactive compound for difficult-to-treat allergies
Irritable bowel syndrome, chronic itching, asthma and migraine are in many cases hard-to-treat conditions. They have in common that they are triggered by an excessive immune response — which in severe cases can be life-threatening. A team of researche…
Clinical trials to test vaccine against Alzheimer’s-promoting tau protein
Researchers hope to launch human clinical trials in their quest for a vaccine to prevent the buildup of pathological tau after demonstrating that this vaccine generated a robust immune response in both mice and non-human primates.
B cells found to be crucial for long-term vaccine protection, new study shows
Researchers have uncovered a critical, previously underappreciated role for B cells in vaccine protection. Best known for producing antibodies, B cells also guide other immune cells, specifically CD8 T cells, teaching them how to mount lasting defenses…
Post-treatment Lyme disease syndrome may be driven by remnants of infection
Scientists believe they know what causes the treated infection to mimic chronic illness: the body may be responding to remnants of the bacteria that causes Lyme that tend to pool in the liver and joint fluid.