Researchers used CRISPR to remove CD33 from donor stem cells, potentially giving doctors a way to attack aggressive blood cancers without destroying the healthy cells patients need after a transplant. In a 30-patient trial, the edited cells successfull…
Chronic inflammation tied to stress, lifestyle, mental health, and socioeconomic conditions may silently change the heart for years before any symptoms appear. People with the highest inflammation levels faced a 43% greater risk of heart attack and str…
Scientists have identified the genetic cause behind the mysterious AnWj blood group antigen, solving a puzzle that began in 1972 and establishing a new blood group system called MAL. The discovery could make it much easier to find extremely rare AnWj-n…
Scientists are testing a counterintuitive way to fight mesothelioma, an aggressive asbestos-linked cancer with few effective treatments. A new experimental mesothelioma drug kills cancer cells by disabling PRX3, an antioxidant defense that tumors use t…
Scientists have discovered that some severe genetic disorders linked to rapid aging may be driven not just by damaged DNA, but by the body’s overreaction to that damage. When broken DNA fragments leak into the wrong part of a cell, an immune sensor cal…
Scientists discovered that aging cells can use malfunctioning mitochondria to unlock inflammatory genes and keep the immune system stuck in a prolonged state of alert. Blocking one part of this process reduced inflammation and improved healthy aging in…
Scientists have uncovered a natural braking system that helps the immune system switch off inflammation and prevent harmful immune cells from building up. Boosting this pathway in people reduced inflammation-related immune changes and sped up pain reli…
Researchers found that blocking IL1RAP could disrupt a powerful inflammatory network that helps pancreatic cancer survive treatment. In preclinical experiments, the approach reduced tumor-protecting cells and fibrosis while boosting the activity of can…
UCLA researchers developed ready-made cancer-fighting T cells from cord blood stem cells that can attack solid tumors through two separate detection systems. In mice, a single dose controlled cancer and extended survival while avoiding a dangerous comp…
Scientists have found evidence that vulnerability to rheumatoid arthritis may begin before birth. Finger joints commonly affected by the disease develop with different tissue structures and larger populations of specialized fibroblasts than joints that…
