Immune System News -- ScienceDaily Analyzing the genetics of patients that responded well to checkpoint blockade revealed mutations in the gene Asxl1 in immune T cells. Disrupting the Asxl1 gene in T cells enhanced response to immune checkpoint blockade and improved long-term tumor cont…
Inflammation of the arteries is a primary precursor and driver of cardiovascular disease — the No. 1 killer of people in the United States. This inflammation is associated with the buildup of dangerous plaque inside the arteries. Advanced treatments a…
A human cell culture model of the lung’s most important immune cells, alveolar macrophages, helped make a key finding that is prompting researchers to rethink the role of another immune protein.
Researchers have demonstrated that patients with metastatic non-squamous non-small cell lung cancer (NSCLC) harboring specific mutations in the STK11 and/or KEAP1 tumor suppressor genes were more likely to benefit from adding the immunotherapy tremelim…
Scientists have recreated the growth of Lewy bodies in human neurons and followed their formation to gain important insight into why and how they form. Critically, they find that immune challenge is important for this process, identifying a previously …
In the fight against cancer, chimeric antigen receptor (CAR) T cell therapy has achieved notable success in treating blood cancers. However, it has been largely ineffective against solid tumors. A study demonstrates that a different immunotherapy appro…
Researchers have discovered a natural immune mechanism in mice that stops escaped cancer cells from developing into tumors elsewhere in the body.
Breakthrough research uses nanoparticles to help the body accept transplanted organs without lifelong immunosuppressive drugs, reducing risks.
A new study reveals critical insights into the role of gamma-delta T cells across 33 cancer types, shedding light on their potential as clinical biomarkers and therapeutic targets in cancer treatment. This comprehensive analysis represents a significan…
Researchers have found a potential new way to improve the treatment of multiple sclerosis (MS) using a novel combined therapy. The results build on two harmonized Phase I clinical trials, focusing on the use of Vitamin D3 tolerogenic dendritic cells (V…
