The immune system’s moonlighters

Scientists have discovered that the immune system stalwart I B has a moonlighting gig. A tiny protein sequence within I B activates another family of key immune proteins called POUs. The discovery may point to a new drug target for various autoimmune d…

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Inflammation: Targeting the transporter

Using specially-developed nanobodies that bind to SPNS2 and enlarge the entire structure, the enlarged SPNS2 structure allows the S1P molecules to be viewed via cryogenic electron microscopy. Scientists have analyzed the structure of the SPNS2 protein …

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