A new paper published in Gene Therapy raises serious concerns about the effectiveness of gene therapy for Duchenne muscular dystrophy (DMD), after the treatment failed to show significant benefit in a large-scale clinical trial.
Researchers from the A*STAR Genome Institute of Singapore (A*STAR GIS), together with collaborators from South Korea, Japan, Thailand, and India, have assembled the world’s first Asian Immune Diversity Atlas (AIDA)—a multi-national survey of human bloo…
Investigators at Mass General Brigham have uncovered how resistance to chemotherapies may occur in some cancers. Researchers focused on a pathway that harnesses reactive oxygen species (ROS) to kill cancer cells. The study found that mutations to VPS35…
Our cells harbor a DNA detector termed cGAS to inform the immune system of viral and bacterial infections, cell death, as well as transformation during cancer. Researchers led by Ikerbasque Research Professor Sergio P. Acebrón (University of the Basque…
In multiple sclerosis (MS), antibodies to the common Epstein-Barr virus can accidentally attack a protein in the brain and spinal cord. New research shows that the combination of certain viral antibodies and genetic risk factors can be linked to a grea…
Although there are tumor suppressor genes in normal cells to prevent cancer, gene mutations can cause a normal cell to become a cancerous one. Among those genes, TP53 (encoding the p53 protein) has been identified as the most frequently mutated gene th…
A team of researchers at NYU Abu Dhabi has uncovered how genetic and lifestyle factors influence immune responses to malaria in children from two large West African ethnic groups. The study found that children from the Fulani group have a distinct immu…
Along with defending against pathogens, the body’s innate immune system helps to protect the stability of our genomes in unexpected ways—ways that have important implications for the development of cancer, researchers at Memorial Sloan Kettering Cancer…
An ancient gene mutation among First Nations inhabitants of Oceania may make them more susceptible to infectious diseases like influenza, according to a new study by scientists at the University of Colorado Anschutz Medical Campus.
Development of B cells, white blood cells that make antibodies, follows a progression of stages: common lymphoid progenitors, pre-pro-B cells, pro-B cells, pre-B cells, immature B cells, and then more mature and specialized B cells. By the time the dev…
