Gene therapies hold immense promise for treating sight loss. These therapies use a modified, harmless virus to deliver therapeutic genes directly to diseased cells, helping them to function normally again.
Yale University School of Medicine reports that cysteinyl leukotrienes released by intestinal mast cells are essential for anaphylaxis after food ingestion in mice, while responses to intravenous allergen challenge proceed without that requirement.
Most vaccines are designed to provide immunity against just one pathogen. Vaccines for chicken pox (caused by varicella-zoster virus) were only developed to fight that one disease, for example.
Many major cancers, including those of the lung, breast and prostate gland, spread to the bones as they progress. These bone metastases are often debilitating, even deadly. They are also notoriously resistant to all kinds of treatment, including immuno…
Immunotherapy uses the body’s immune system to recognize and destroy cancer cells. One way to do this is through immune checkpoint inhibitors.
At the time when patients with lupus, or systemic lupus erythematosus (SLE), are diagnosed, approximately 15% to 30% will already have the inflammation-caused kidney disease lupus nephritis, which compromises kidney function and can lead to kidney fail…
Scientists at the National Institute of Biological Sciences, Beijing report that two pore-forming proteins from the common mold Alternaria alternata puncture airway epithelial membranes and initiate signals that drive allergic airway inflammation.
The U.S. Food and Drug Administration has approved Apellis Pharmaceuticals’ Empaveli (pegcetacoplan) as the first treatment for C3 glomerulopathy (C3G) or primary immune complex membranoproliferative glomerulonephritis (IC-MPGN).
A paper published in Cell highlights how researchers have leveraged AI-based computational protein design to create a novel synthetic ligand that activates the Notch signaling pathway, a key driver in T-cell development and function.
Allergic to peanuts? Bees? Pollen? Cockroaches? There’s a shot for that.
