A large interdisciplinary team of researchers has found that as mice age, levels of a certain type of immunoglobulin escalate, exacerbating tissue aging. In their paper published in the journal Cell, the group describes how they analyzed tissue from mu…
A team of Rice University bioengineers has developed a mathematical model that clarifies why interleukin-12 (IL-12)—a potent immune-boosting protein that holds promise for cancer treatment—loses effectiveness over time when used as an immunotherapeutic…
Recent research reveals that the immune system interacts with the body’s internal clock, influencing both fat storage and temperature regulation.
Berry-flavored vapes can weaken the lungs’ natural defenses, making it harder for the body to fight off infections, research suggests. The study, published in Proceedings of the National Academy of Sciences, compared effects of flavored e-cigarettes to…
From sending cancer into remission to alleviating COVID-19 symptoms, immunotherapy can provide revolutionary disease treatments. Immunotherapies use antibodies—proteins that bind to cell markers called antigens—to target and eliminate the antigen. But …
The first 3D images of a whole human thymus have been created using a specialized X-ray technique by researchers from University College London (UCL) and the Francis Crick Institute. The highly-intricate images showed that structures called Hassall’s b…
Macrophage cells are the immune system’s frontline soldiers, early on the scene to protect the body from foreign invaders. These cells answer the immune system’s critical question for the rest of its troops: friend or foe?
Investigators led by Pablo Penaloza-MacMaster, Ph.D., associate professor of Microbiology-Immunology, have discovered that administering an antibody treatment four days after mRNA vaccination enhances immune responses and vaccine efficacy in mice, acco…
For kidney transplant recipients experiencing antibody-mediated rejection, the current standard of care involves removing donor-specific antibodies (DSAs) through plasmapheresis (PLEX)—a procedure that removes antibodies from the plasma portion of the …
Chronic active antibody-mediated rejection (caAMR) is a common cause of allograft loss after transplantation, with no approved therapies. Clazakizumab, a monoclonal antibody that targets the inflammatory cytokine interleukin-6 (IL-6), stabilized kidney…
