Patient-driven discovery reveals potential target for autoimmune diseases
A medical mystery served as the genesis for a Yale-led study that has promising implications for treating a range of autoimmune diseases.
Immunology
Research suggests early life antibiotic increases asthma risk, providing clues to potential prevention of adult asthma
Early exposure to antibiotics can trigger long term susceptibility to asthma, according to new research from Monash University. Importantly, the research team isolated a molecule produced by gut bacteria that in the future could potentially be trialed …
Q&A: Researchers discuss cellular inflammation uncovered in rare neurodegenerative condition
Researchers at The Hospital for Sick Children (SickKids) have found that inflammation in an immune cell may be responsible in part for some severe symptoms in a group of rare genetic conditions called lysosomal storage diseases (LSDs).
Rising incidence of chronic allergic disorder in Japan confirmed by large-scale data analysis
In one of the first studies of its kind in Japan, Osaka Metropolitan University-led researchers uncovered the incidence and prevalence of the chronic allergic disorder eosinophilic esophagitis, or EoE.
Immunogenicity of human-induced pluripotent stem cell-derived cardiomyocyte sheets
Human induced pluripotent stem (hiPS) cells refer to stem cells derived from adult somatic cells like blood or skin cells. hiPS-derived cardiomyocytes (hiPC-CMs) have shown promise in treating ischemic heart disease. However, their clinical application…
Inulin-gel-based oral immunotherapy may offer long-awaited treatment for food allergy sufferers
A study from the University of Michigan has identified a potential new treatment for food allergies in inulin, a naturally occurring plant fiber commonly used as a supplement, a prebiotic in soda, a replacement for sweeteners and for other products and…
Small molecules induce trained immunity, opening a new approach to fighting disease
Vaccines provide a front-line defense against dangerous viruses, training adaptive immune cells to identify and fight specific pathogens.
Scientists discover how to improve vaccine response to potentially deadly bacterium
Researchers from Trinity College Dublin have taken a leap forward in understanding how we might fight back against the potentially deadly MRSA bacterium. They have shown in an animal model that targeting a key suppressive immune molecule (IL-10) during…
New pathway in immune defense discovered: Interaction of monocytes and platelets decoded
Monocytes, a special type of white blood cell, secrete cytokines as inflammatory messengers that are crucial for an appropriate immune response. Researchers at the University Hospital Bonn (UKB) and the University of Bonn have now discovered that plate…
Scientists create first mouse model with complete, functional human immune system
A breakthrough for biomedical research promises new insight into immunotherapy development and disease modeling. Scientists at The University of Texas Health Science Center at San Antonio have created a humanized mouse model with a human immune system …