Scientists pioneer immunotherapy technique for autoimmune diseases
Mayo Clinic scientists have developed an immunotherapy strategy that potentially lays the groundwork for treating a spectrum of autoimmune diseases.
Immunology
Researchers identify new way to inhibit immune cells that drive allergic asthma
Researchers at the Keck School of Medicine, University of Southern California, have discovered that a protein called Piezo1 prevents a type of immune cell in the lung from becoming hyperactivated by allergens. The study, to be published in the Journal …
An infamous ‘inflammasome’—a rogue protein complex—appears to underlie a rare and disabling autoimmune disorder
Autoimmune diseases are among the most puzzling because turncoat constituents of the body wage a constant state of war. Sometimes the underlying cause of an autoimmune condition is so obscure—hidden within chemical miscues of the body—that a long inves…
Researchers discover skin biomarkers in infants that predict early development of food allergies
Food allergies occur often in childhood and can be severe or even fatal. Researchers at National Jewish Health are working to develop a program to prevent food allergies and have now identified early predictors of the condition.
Old immune systems revitalized in mouse study, may improve vaccine response in the elderly
Planes, trains, boats, automobiles and even feet. During the past decades and centuries, global travel and human migration have made all of us more worldly—from our broadening awareness of the world beyond our birthplaces, to our more sophisticated pal…
Research unveils metabolic strategies to enhance CAR-T cell therapy
While cancer remains one of the leading global causes of death, advancements in cancer therapies have significantly improved its manageability and potential for cure. Among these revolutionary cancer treatments are chimeric antigen receptor-T (CAR-T) c…
Researchers find new way to curb asthma attacks
A protein that shuts down immune cells in the lungs could be key to a new treatment for asthma attacks, a new report says.
Macrophages produce heat from brown adipose tissue in response to cold, study reveals
Researchers from University of Tsukuba have elucidated the molecular mechanism by which macrophages, a type of immune cell, control heat production in brown adipose tissue to increase the body temperature in response to cold.
CARv3-TEAM-E T-cell treatment beneficial for recurrent glioblastoma
For patients with recurrent glioblastoma, treatment with chimeric antigen receptor (CAR) T-cells engineered to target the epidermal growth factor receptor (EGFR) variant III tumor-specific antigen, in addition to the wild-type EGFR protein, through sec…
Lymph node-like biomaterial scaffold for augmenting CAR-T cell therapy
In a study published in the journal National Science Review, a research team aimed to enhance treatment efficacy of CAR-T cell therapy for solid tumors. The research was led by Dr. Zhen Gu and Dr. Hongjun Li from the College of Pharmaceutical Sciences …