Could CAR-T therapy be a cure for lupus? Early trials show promise
Systemic lupus erythematosus (SLE) is a complex autoimmune disease with a spectrum of very different manifestations and variable severity.
Medical Xpress
Withdrawal of kidney treatment significantly benefits patients and NHS
Early withdrawal of a treatment for patients with a rare kidney disease is possible without relapse, safer for patients and saves the NHS millions of pounds, new research has revealed.
Bone metastases cultivate immature immune cells to resist immunotherapy
Many major cancers, including those of the lung, breast and prostate gland, spread to the bones as they progress. These bone metastases are often debilitating, even deadly. They are also notoriously resistant to all kinds of treatment, including immuno…
New technology maps immune cell communication to guide personalized cancer therapies
An interdisciplinary team of scientists has developed a technology to decode immune cell communication. By measuring interactions between cells, the method offers insights into how the human body fights viral infections, how malfunctions can lead to au…
Bystander T cells can enhance antitumor effects of bispecific antibody
T-cell redirection therapy using chimeric antigen receptor (CAR) T cells and/or bispecific antibody (BsAb) has been established and become a promising treatment strategy for relapsed/refractory B-cell lymphomas. To further improve their therapeutic eff…
Lung damage not main driver of persistent infections in cystic fibrosis, study finds
A new study meticulously sampled different lung regions in people with cystic fibrosis to understand why infections persist after new treatments.
Inactivation of key pathway boosts the body’s immune response against tumors
Immunotherapy uses the body’s immune system to recognize and destroy cancer cells. One way to do this is through immune checkpoint inhibitors.
Certain RNA modifications could contribute to the development of autoimmune disorders
New research published in Nature has uncovered powerful evidence that may explain why a new chemical modification of RNA is made in cells.
Replacing brain immune cells in mice slows neurodegeneration: Technique may help with diseases like Alzheimer’s
Tay-Sachs and Sandhoff diseases, genetic disorders affecting the brain, have no effective treatment and are typically fatal within the first years of life.
Computational tool ranks compounds to improve cancer immunotherapy effectiveness
A study published in Cell Reports Medicine reports a scalable, data-driven computational framework for designing combinatorial immunotherapies, offering hope for patients with poor responses to current immunotherapies.