Scientists pioneer immunotherapy technique for autoimmune diseases
Mayo Clinic scientists have developed an immunotherapy strategy that potentially lays the groundwork for treating a spectrum of autoimmune diseases.
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Researchers identify new way to inhibit immune cells that drive allergic asthma
Researchers at the Keck School of Medicine, University of Southern California, have discovered that a protein called Piezo1 prevents a type of immune cell in the lung from becoming hyperactivated by allergens. The study, to be published in the Journal …
Scientists have a new tool in the race to improve the diagnosis and prognosis of sepsis
Researchers from Lund University in Sweden have identified distinct molecular signatures associated with the clinical signs of sepsis that could provide more accurate diagnosis and prognosis of sepsis, as well as help to target specific therapies at pa…
An infamous ‘inflammasome’—a rogue protein complex—appears to underlie a rare and disabling autoimmune disorder
Autoimmune diseases are among the most puzzling because turncoat constituents of the body wage a constant state of war. Sometimes the underlying cause of an autoimmune condition is so obscure—hidden within chemical miscues of the body—that a long inves…
Researchers discover skin biomarkers in infants that predict early development of food allergies
Food allergies occur often in childhood and can be severe or even fatal. Researchers at National Jewish Health are working to develop a program to prevent food allergies and have now identified early predictors of the condition.
Researchers develop AI-based tool paving the way for personalized cancer treatments
In the ongoing fight against cancer, scientists around the globe are exploring innovative approaches to unlock the mysteries of the human immune system—the complex network of organs, cells and proteins that defends the body against disease.
COVID-19 antibody discovery could explain long COVID
UVA Health researchers have discovered a potential explanation for some of the most perplexing mysteries of COVID-19 and long COVID. The surprising findings could lead to new treatments for the difficult acute effects of COVID-19, long COVID, and possi…
Clinical trial: Some sarcoma patients improve with T cell immunotherapy
A clinical trial led by researchers at Washington University School of Medicine in St. Louis has shown that a T cell immunotherapy—in which the patients’ own T cells are genetically modified to attack and kill cancer cells—is effective in treating some…
Research finds T cell subset significantly expands in spleen and brain after virus infection
It is currently unclear where T cells in the brains of teleosts originate from. While viewing the central nervous system (CNS) as immune privileged has been widely accepted, previous studies suggest that T cells residing in the thymus but not in the sp…
Researchers create new tool for assessing risk of kidney injury after chemotherapy
Using patient data from six major U.S. cancer centers, Brigham researchers and collaborators developed a risk prediction model for moderate-to-severe kidney injury after receiving the chemotherapy drug cisplatin in the largest, first generalizable stud…