Emerging evidence underscores a key role for the tumor microenvironment in supporting or suppressing cancer immunity. Of note, pro- and antitumor immune activity is controlled by not only the types of immune cells present but also their spatial arrange…
The intensity of T cell receptor (TCR) signaling controls thymic positive and negative selection of conventional T cells (Tconv cells) and regulatory T cells (Treg cells), as well as their peripheral activation. Accordingly, the effects of graded TCR s…
The success of cancer immunotherapy depends on the mobilization of leukocytes with the capacity to eliminate tumor cells. γδ T cells represent a lymphocyte lineage with strong cytotoxic potential and abundant production of antitumor cytokines…
Glycan-binding proteins (GBPs), including Galectins, sialic acid–binding immunoglobin-type lectins (Siglecs), and C-type lectin receptors (CLRs), are key regulators of immune cell development, activation, differentiation, trafficking, and homeost…
The major effector cells of antitumor immunity are killer lymphocytes that recognize and eliminate tumor cells. The fact that tumor cells look a lot like normal cells poses a challenge to antitumor immune control. A danger signal from the tumor or from…
Immune inhibitory receptors are negative regulators of immune cells and, as such, dampen immune responses. Blocking inhibitory receptors in cancer results in not only powerful antitumor responses but also a diverse array of immune-related adverse event…
Here we introduce the Cross-Organ Neuroimmunology of Behavior (CONB) Network, a framework that reconceptualizes behavior as an emergent property of a distributed, whole-body immune–brain network. It builds on knowledge of neuroimmune communicatio…
Affinity for antigen is a fundamental parameter of humoral immunity. It determines the B cell clones that participate in the response, it is a readout of clonal selection as the response progresses, and the magnitude of its improvement in T cell–…
The exploration of neuroimmune interactions at tissue barriers has become pivotal for our understanding of how organisms survive and adapt to challenging environments. Serving both as a physical barrier and a sensory organ, the skin has evolved as a ke…
FOXP3+ regulatory T cells (Tregs) have well-defined roles in limiting systemic immune responses against diverse stimuli. However, the observation that a subset of Tregs also enter nonlymphoid tissues, where they assume additional functions, has become …
