Publicaciones

Outcome measures in systemic lupus erythematosus

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Curr Opin Immunol. 2026 Apr 30;100:102782. doi: 10.1016/j.coi.2026.102782. Online ahead of print. ABSTRACT Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease characterized by fluctuating multisystem involvement, relapsing-remitting activity, and substantial risk of irreversible organ damage. Standardized disease activity indices have facilitated clinical trials and research, yet integration into clinical practice has not occurred for … Read more

Scaling immunity: sickness as a host defense strategy. A Clare Sparling

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Trends Immunol. 2026 Apr 30:S1471-4906(26)00076-1. doi: 10.1016/j.it.2026.03.015. Online ahead of print. ABSTRACT Sickness, or sickness behavior, is a state of altered physiology and behavior generated by the brain-immune axis during infection, which is generally assumed to contribute to host defense. Here, we examine this assumption by framing sickness as organismal-scale immunity and explore predicted parallels … Read more

Optimal donor selection for transplant to reduce GVHD risk and augment graft-versus-malignancy efficacy

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Curr Opin Immunol. 2026 Apr 29;100:102783. doi: 10.1016/j.coi.2026.102783. Online ahead of print. ABSTRACT Allogeneic hematopoietic cell transplantation (alloHCT) is curative for many patients with high-risk, hematologic malignancies. AlloHCT depends on a graft versus malignancy (GVM) phenomenon, whereby donor-derived immune cells recognize and eradicate malignant host cells. Successful GVM correlates with the risk of alloreactivity against … Read more

A dynamic vascular–inflammatory–fibrotic loop in systemic sclerosis: an integrative immuno-vascular framework

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BackgroundSystemic sclerosis (SSc) is characterized by a complex and heterogeneous interplay between vascular dysfunction, immune activation, and progressive fibrosis. Despite advances in molecular characterization, therapeutic responses remain inconsi…

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