Publicaciones

Diminished FcγRIIa expression reduces antibody-mediated phagocytosis by low-density neutrophils in obesity​Carlos Blanco-Camarillo on 15 de September de 2026 at 10:00

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J Leukoc Biol. 2026 Sep 15:qiag128. doi: 10.1093/jleuko/qiag128. Online ahead of print. ABSTRACT Obesity is a chronic inflammatory disease associated with an increased risk of various medical complications, including cardiovascular problems, diabetes, and infectious diseases. A central element of the immune system associated with inflammation and antimicrobial function is neutrophils. Recently, distinct neutrophil subpopulations have … Read more

FasL-mediated death of activated intratumoral T cells drives secondary resistance to cancer immunotherapy

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Cancer Immunol Res. 2026 Sep 15. doi: 10.1158/2326-6066.CIR-25-1567. Online ahead of print. ABSTRACT Cancer progression following an initial response to immunotherapy (secondary resistance; 2°R) is a major and poorly understood problem. We treated mice bearing B16 melanoma with a combination of a regulatory T cell (Treg) depleting, non-IL-2 blocking antibody (anti-CD25NIB) and an autologous cancer … Read more

Arid2 regulates peripheral B cell maturation and germinal-center responses in vivo

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J Immunol. 2026 Aug 29;215(9):vkag247. doi: 10.1093/jimmun/vkag247. ABSTRACT SWI/SNF chromatin remodeling complexes regulate gene expression during development and differentiation. These complexes exist in distinct forms, including the polybromo-associated BAF (PBAF) complex, defined by the ARID2 subunit. ARID2 is frequently mutated in B cell leukemias, but its role in normal B cell development remains unknown. Using … Read more

Scopolamine ameliorates psoriasis by blocking M1 receptor-mediated IL-23 production in dendritic cells

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J Immunol. 2026 Aug 29;215(9):vkag179. doi: 10.1093/jimmun/vkag179. ABSTRACT Psoriasis is a chronic inflammatory skin disease involving intricate neuroimmune crosstalk. However, the specific mechanisms and therapeutic targets remain elusive. In this study, a pilot clinical trial demonstrated that intravenous scopolamine, a muscarinic receptor antagonist, significantly ameliorated skin lesions in psoriasis patients. Consistently, scopolamine reduced inflammation in … Read more

Metabolite-Mediated Crosstalk Between Neutrophils, Commensal Bacteria, and Dendritic Cells Is Associated with Intestinal Immune Responses​Sun-Hwa Kim on 15 de September de 2026 at 10:00

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J Leukoc Biol. 2026 Sep 15:qiag123. doi: 10.1093/jleuko/qiag123. Online ahead of print. ABSTRACT The intestinal immune system relies on coordinated interactions between innate immune cells and commensal bacteria. How metabolites integrate host-microbe communication in the gut remains incompletely understood. Using neutrophil activation assays, bacterial chemotaxis analysis, short-chain fatty acid profiling, and imaging of inflamed intestinal … Read more

LRIG2 suppresses NK cell-induced GSDME-mediated pyroptosis via the LAMP1-STAT3 pathway in glioma

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Background
Gliomas are resistant to current therapies, and natural killer (NK) cell-based immunotherapy shows limited efficacy. Gasdermin E (GSDME)-mediated pyroptosis contributes to NK-induced tumor killing, but NK cell dysfunction in the glioma micr…

The light side of mast cell degranulation: delivering macrophage repair through molecular condensates​Alejandro Schcolnik-Cabrera on 15 de September de 2026 at 10:00

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J Leukoc Biol. 2026 Sep 15:qiag125. doi: 10.1093/jleuko/qiag125. Online ahead of print. ABSTRACT Mast cell (MC) degranulation is commonly viewed as the rapid release of preformed inflammatory mediators into the extracellular environment. In a recent study published in the Journal of Experimental Medicine, Salm et al. described a more spatially controlled form of MC communication … Read more

Spatially instructed checkpoints in antitumor NK cell immunity. Ruifeng Wang

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Trends Immunol. 2026 Sep 14:S1471-4906(26)00228-0. doi: 10.1016/j.it.2026.08.012. Online ahead of print. ABSTRACT Natural killer (NK) cell immunotherapies remain less effective in solid tumors than in hematologic malignancies. Poor infiltration, checkpoint engagement, and metabolic stress contribute, but these mechanisms often operate within spatially organized niches. We develop the concept of spatially instructed checkpoints: inhibitory programs locally … Read more

Impaired antigen clearance of macrophages associates with heart failure and non-obstructive azoospermia: insights from transcriptomics, in silico knockout, and in vitro validation

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BackgroundHeart failure (HF) and non-obstructive azoospermia (NOA) are high-burden diseases that share chronic inflammation and tissue injury. Macrophages are key regulators in both conditions, yet whether a common molecular basis exists remains unclea…

From disease to syndrome pattern: a study on the differentiation of traditional Chinese medicine syndrome patterns in asthma using multi-omics characterization

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BackgroundBronchial asthma is a highly heterogeneous chronic inflammatory airway disorder. Syndrome differentiation-guided Traditional Chinese Medicine (TCM) treatment for asthma delivers distinct advantages, including fewer adverse reactions and super…

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