Publicaciones

The post-transcriptional regulator HuR promotes immune evasion in pancreatic ductal adenocarcinoma

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Cancer Immunol Res. 2026 Sep 4. doi: 10.1158/2326-6066.CIR-26-0472. Online ahead of print. ABSTRACT The tumor microenvironment (TME) of pancreatic ductal adenocarcinoma (PDAC) is characterized by restrained function of effector T cells that drives resistance to immunotherapy. While tumor-extrinsic stroma and myeloid cells have been shown to mediate PDAC immune evasion, the role of tumor-intrinsic post-transcriptional … Read more

The Modular CAR: Adapting T Cells without Reengineering Them

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Cancer Immunol Res. 2026 Sep 4:OF1-OF2. doi: 10.1158/2326-6066.CIR-26-0906. Online ahead of print. ABSTRACT The therapeutic potential of chimeric antigen receptor (CAR) T cells has long been limited by the static nature of the engineered receptor; once manufactured, the cell is committed to a single antigen, unable to respond to the immune evasion and antigen heterogeneity … Read more

Evaluating the potential of candidate surrogate endpoints for overall survival in treatment-naive metastatic melanoma treated with anti-PD-1-based regimens with or without anti-CTLA-4 therapy

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Background
Using surrogates for overall survival (OS) may expedite the development of, and patient access to, novel treatments. We assessed potential surrogates for OS in patients with metastatic melanoma treated with nivolumab-containing regimens in …

Intoxication, Inflamm-aging, and Injury: My Journey through Leukocyte Biology​Rachel H McMahan on 4 de September de 2026 at 10:00

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J Leukoc Biol. 2026 Sep 4:qiag121. doi: 10.1093/jleuko/qiag121. Online ahead of print. ABSTRACT As a scientist, teacher, research mentor, and mom, I asked myself, “what is my legacy?” Legacies usually have numbers associated with them. When asked this question in the past, I summed my accomplishments in terms of who, not what. First and foremost, … Read more

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