Publicaciones

Neutrophils in Tumorigenesis and Progression: Dual Roles and Clinical Translation​Kexin Hu on 16 de June de 2026 at 10:00

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J Leukoc Biol. 2026 Jun 16:qiag079. doi: 10.1093/jleuko/qiag079. Online ahead of print. ABSTRACT Neutrophils, the most abundant innate immune cells, act as first responders in host defense via phagocytosis, degranulation, ROS production and Neutrophil Extracellular Traps (NETs) formation. Emerging evidence reveals that neutrophils are highly plastic and heterogeneous, acting as critical regulators in tumor biology. … Read more

Lymphatic endothelial cells actively shape immune responses in the lungs

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Curr Opin Immunol. 2026 Jun 15;101:102802. doi: 10.1016/j.coi.2026.102802. Online ahead of print. ABSTRACT Lymphatic vessels maintain fluid balance and immune protection by transporting fluid, solutes and cells from tissue interstitial spaces to lymph nodes. The lymphatic endothelial cells that form lymphatics differentiate throughout the body to fulfil organ-specific roles. In the lungs, specialised pulmonary lymphatic … Read more

Human XIRP1 is a new podosome protein targeting cytosolic bacteria as part of the IFN-γ defense program

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J Immunol. 2026 Jun 7;215(6):vkag116. doi: 10.1093/jimmun/vkag116. ABSTRACT Interferon-gamma (IFN-γ) is a powerful transactivating signal eliciting hundreds of IFN-stimulated genes (ISGs) in humans to help combat infection. Most ISGs remain uncharacterized, and here we searched for actin-binding candidates that could potentially target intracellular pathogens to block their spread or promote immune cell migration into infected … Read more

Context-dependent androgen control of T cell immunity. Jianhua Xiong

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Trends Immunol. 2026 Jun 15:S1471-4906(26)00156-0. doi: 10.1016/j.it.2026.06.004. Online ahead of print. ABSTRACT While androgen deprivation is widely used in urological oncology to restrain tumor growth and prevent T cell exhaustion, Lee et al. reveal a striking reversal in glioblastoma. In glioblastoma, androgen loss triggers microglial cytokines, activates the hypothalamic-pituitary-adrenal axis, and induces glucocorticoid-dependent T cell … Read more

Interleukin-1-mediated inflammatory memory: Protective training or maladaptive tumor imprinting?. Despoina Xanthopoulou

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Semin Immunol. 2026 Jun 15;83:102047. doi: 10.1016/j.smim.2026.102047. Online ahead of print. ABSTRACT Interleukin-1 (IL-1) exerts a pivotal role in the regulation of innate immune responses and inflammatory processes. Beyond its local effects at the site of inflammation, IL-1 acts as a systemic regulator of hematopoiesis by reprogramming hematopoietic stem and progenitor cells (HSPCs), thereby shaping … Read more

Calibrating microglia states in Alzheimer’s disease: decoding immune-metabolic networks and nano-targeted multicomponent therapies

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Alzheimer’s disease treatment is shifting from pathology removal to regulating the brain microenvironment. Anti-Aβ monoclonal antibodies, such as lecanemab and donanemab, provide statistically significant disease-modifying effects but offer only modest…

Exploratory metabolomic analysis for identifying systemic signatures of Helicobacter pylori infection in children

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BackgroundInfections caused by the Gram-negative bacteria Helicobacter pylori (H. pylori) can result in gastritis, gastric or duodenal ulcers, and gastric cancer in humans. Examining quantitative changes in soluble biomarkers linked to H. pylori infect…

HLA DP/DRA molecule regulates systemic inflammation and neuroinflammation, aggravates cognitive impairment and long-term anxiety in murine model of sepsis-associated encephalopathy

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Sepsis-associated encephalopathy (SAE) is a severe and common neurological complication of sepsis, characterized by symptoms ranging from mild confusion, delirium, deep coma, and severe cognitive dysfunction. Previous epidemiological and bioinformatics…

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