An international team of UK and US scientists has discovered that the activity of macrophages—a type of white blood cell that engulf pathogens and cancer cells—can be used to predict whether or not a melanoma patient will respond to immunotherapy. Thei…
Fighting off infections when one has a chronic disease is a common problem, and during the COVID-19 pandemic that scenario often turned out to be dangerous and deadly. A new study led by Stony Brook Medicine demonstrates that advanced kidney disease co…
A study published in Human Gene Therapy has involved the generation of a human monoclonal antibody (mAb) directed against human eosinophils. The heavy and light chains of that fully human anti-human eosinophil mAb were delivered via an adeno-associated…
Mice infected with the bacteria that cause tuberculosis (TB) fared better when treated with an experimental compound that modulates immune responses than untreated mice did, according to a study led by Christina Stallings, a professor of molecular micr…
Psychological stress is known to exacerbate skin allergies, but the underlying molecular mechanisms remain poorly understood.
Alcohol-associated hepatitis (AH) is a critical global health issue characterized by acute liver inflammation and an elevated risk of mortality in its severe form (sAH). While the condition has been studied extensively, effective treatments remain scar…
Metabolites—small molecules within cells, biofluids, tissues or organisms—play an integral role in various diseases, and studying the many metabolites (metabolomics) can teach us how the body works in ways that help researchers develop new treatments, …
Southampton scientists working to improve survival for cancer patients have identified a key characteristic of the disease that could make treatment more effective.
Your blood is a delicate mixture. Researchers and clinicians often use blood to learn what’s going on inside our bodies, in part because siphoning off a tube of blood is easier and less painful than taking biopsies of an internal organ.
Researchers at Children’s Hospital of Philadelphia (CHOP) and the Perelman School of Medicine at the University of Pennsylvania have developed a new screening technology, Aptamer-based T Lymphocyte Activity Screening and SEQuencing (ATLAS-seq), to bett…
