Small molecules induce trained immunity, opening a new approach to fighting disease
Vaccines provide a front-line defense against dangerous viruses, training adaptive immune cells to identify and fight specific pathogens.
Medical Xpress
Researchers find a common immune system mechanism between pregnancy and cancer
To understand why some cancers successfully circumvent the immune system to grow unchecked, researchers turned to pregnancy.
Study highlights the importance of infection prevention after CAR T-cell therapy
Researchers at Dana-Farber Cancer Institute, in collaboration with colleagues from Memorial Sloan Kettering Cancer Center in New York (Dr. Kai Rejeski) and the LMU Hospital in Munich, Germany (Dr. Tobias Tix), have found that infections were the main d…
Scientists discover how to improve vaccine response to potentially deadly bacterium
Researchers from Trinity College Dublin have taken a leap forward in understanding how we might fight back against the potentially deadly MRSA bacterium. They have shown in an animal model that targeting a key suppressive immune molecule (IL-10) during…
World’s first CAR-T cell therapy for a child with lupus
In June 2023, Uresa A. (who was 15 years old at the time) received CAR-T cells at Universitätsklinikum Erlangen. The treatment was the last resort to slow down systemic lupus erythematosus (SLE), which is a serious autoimmune disease that was attacking…
Long COVID uncharacteristic immune cell activity and SARS-CoV-2 RNA found in the gut two years after infection
A large team of medical researchers at the University of California, San Francisco, and CellSight Technologies has found that some patients who develop long COVID show signs of uncharacteristic immune cell activity in many of their organs and some have…
New pathway in immune defense discovered: Interaction of monocytes and platelets decoded
Monocytes, a special type of white blood cell, secrete cytokines as inflammatory messengers that are crucial for an appropriate immune response. Researchers at the University Hospital Bonn (UKB) and the University of Bonn have now discovered that plate…
Scientists create first mouse model with complete, functional human immune system
A breakthrough for biomedical research promises new insight into immunotherapy development and disease modeling. Scientists at The University of Texas Health Science Center at San Antonio have created a humanized mouse model with a human immune system …
New insights into metabolic and immune pathway interactions in obesity
Metabolic and immune pathways are highly regulated and interwoven by multiple mechanisms to govern metabolic health. Dysregulation of these pathways underlies the development of metabolic diseases such as obesity and type 2 diabetes (T2D), which have b…
Ointment containing DNA molecules can combat allergic contact dermatitis
Researchers at the University of Bonn have isolated a DNA molecule that is suitable for combating allergic contact dermatitis in mice. The aptamer binds to certain immune system messenger substances, rendering them ineffective. This even works if the a…