Trends Immunol. 2024 Nov 20:S1471-4906(24)00276-X. doi: 10.1016/j.it.2024.11.005. Online ahead of print.
ABSTRACT
Tissue-resident memory (TRM) T cells not only control infection and cancer, but also contribute to inflammatory disease. In a recent study, Obers et al. demonstrate that retinoic acid (RA) and TGF-β direct TRM residency in mice, with RA uniquely retaining cells in the intestine by limiting migration. This discovery highlights the potential for harnessing local residency cues to enhance tissue-specific TRM responses.
PMID:39572339 | DOI:10.1016/j.it.2024.11.005