Trends Immunol. 2026 Jul 15:S1471-4906(26)00164-X. doi: 10.1016/j.it.2026.06.008. Online ahead of print. ABSTRACT More than 4 decades after the discovery of MHC restriction, it is clear that the phagocytosis of dying cells is not the only route by which macrophages acquire antigens. Fan and colleagues further expand this paradigm by showing that macrophages can sample a … Read more
Trends Immunol. 2026 Jul 16:S1471-4906(26)00165-1. doi: 10.1016/j.it.2026.06.009. Online ahead of print. ABSTRACT Hepatocellular carcinoma (HCC) remains one of the most lethal malignancies, characterized by a highly complex and dynamic tumor microenvironment in which tumor-associated macrophages (TAMs) are particularly abundant. TAMs regulate tumor initiation, progression, metastasis, and therapy response, making them attractive targets. However, targeting TAMs … Read more
Trends Immunol. 2026 Jul 14:S1471-4906(26)00163-8. doi: 10.1016/j.it.2026.06.007. Online ahead of print. ABSTRACT Macrophages are central regulators of immunity, tissue homeostasis, and repair, whose plasticity enables them to integrate cues from their local microenvironment. Dysregulated macrophages contribute to chronic inflammation, fibrosis, impaired wound healing, and tumor progression. Biomaterials enable the modulation of macrophages through localized delivery … Read more
Trends Immunol. 2026 Jul 8:S1471-4906(26)00161-4. doi: 10.1016/j.it.2026.06.005. Online ahead of print. ABSTRACT CD8+ T cell dysfunction, characterized by impaired effector function, proliferative capacity, and sustained inhibitory receptor expression, limits immune control in both cancer and chronic viral infections. Despite arising from distinct disease processes, these conditions induce a shared state of CD8+ T cell dysfunction, … Read more
Trends Immunol. 2026 Jul 2:S1471-4906(26)00162-6. doi: 10.1016/j.it.2026.06.006. Online ahead of print. ABSTRACT Interleukin-33 (IL-33) is classically viewed as an alarmin, but in cancer, it may do more than merely initiate immunity. I propose that IL-33 scripts the trajectory of immunity through interconnected regulatory layers that influence how host responses are organized and ultimately resolved into … Read more
Trends Immunol. 2026 Jun 25:S1471-4906(26)00137-7. doi: 10.1016/j.it.2026.05.012. Online ahead of print. ABSTRACT Mitochondrial calcium (mtCa2+) has long been framed as a bioenergetic regulator, yet evidence redefines it as a relevant immunometabolic switch. Within the tumor microenvironment, the mitochondrial calcium uniporter (MCU) complex and the NCLX-TMEM65 efflux axis maintain a ‘Goldilocks zone’ of Ca2+ homeostasis. This … Read more
Trends Immunol. 2026 Jun 24:S1471-4906(26)00155-9. doi: 10.1016/j.it.2026.06.003. Online ahead of print. ABSTRACT Antibody-drug conjugates (ADCs) selectively deliver potent chemotherapeutic agents to tumor cells. In clinical settings, the therapeutic benefits of ADCs can be improved when combined with immune checkpoint inhibitors, probably due to the immunogenic nature of ADC-induced tumor cell death, which releases tumor antigens … Read more
Trends Immunol. 2026 Jun 23:S1471-4906(26)00138-9. doi: 10.1016/j.it.2026.06.001. Online ahead of print. ABSTRACT Growing evidence indicates that gut microbiota-derived metabolites are key regulators of immunometabolism in inflammatory bowel disease (IBD). Intestinal epithelial cells and immune cells exhibit profound metabolic alterations in IBD. Microbial metabolites act as intermediates in host-microbe communication, reshaping mitochondrial functions and cellular metabolic … Read more
Trends Immunol. 2026 Jun 19:S1471-4906(26)00139-0. doi: 10.1016/j.it.2026.06.002. Online ahead of print. ABSTRACT Inflammation is a metabolically intensive and tightly regulated process, driven primarily by innate immune cells. Cellular metabolism actively instructs immune signaling and cell fate decisions. Bioenergetic pathways, including glycolysis, mitochondrial respiration, and the tricarboxylic acid cycle, reshape cytokine production and regulate inflammatory cell … Read more
Trends Immunol. 2026 Jun 17:S1471-4906(26)00136-5. doi: 10.1016/j.it.2026.05.011. Online ahead of print. NO ABSTRACT PMID:42309886 | DOI:10.1016/j.it.2026.05.011
