Trends in Immunology

Trends Immunol. 2026 Sep 9:S1471-4906(26)00227-9. doi: 10.1016/j.it.2026.08.011. Online ahead of print. ABSTRACT Clinical immunology is increasingly recognizing diet not merely as baseline metabolic sustenance but as a tunable pharmacological tool. By targeting conserved nutrient-sensing networks and the microbiome, defined nutritional protocols-such as fasting mimetics and specific macronutrient titrations-can actively rewire immune responses. In this review, … Read more

Trends Immunol. 2026 Sep 7:S1471-4906(26)00223-1. doi: 10.1016/j.it.2026.08.007. Online ahead of print. NO ABSTRACT PMID:42705942 | DOI:10.1016/j.it.2026.08.007

Trends Immunol. 2026 Sep 7:S1471-4906(26)00216-4. doi: 10.1016/j.it.2026.08.003. Online ahead of print. ABSTRACT Certain human leukocyte antigen (HLA) alleles occur more often in people with immune-mediated inflammatory diseases (IMIDs) than in unaffected individuals, making HLA one of the strongest inherited contributors to IMID risk. Yet how these alleles promote disease remains unclear. We argue that HLA … Read more

Trends Immunol. 2026 Sep 7:S1471-4906(26)00224-3. doi: 10.1016/j.it.2026.08.008. Online ahead of print. NO ABSTRACT PMID:42705940 | DOI:10.1016/j.it.2026.08.008

Trends Immunol. 2026 Sep 7:S1471-4906(26)00225-5. doi: 10.1016/j.it.2026.08.009. Online ahead of print. NO ABSTRACT PMID:42705939 | DOI:10.1016/j.it.2026.08.009

Trends Immunol. 2026 Sep 1:S1471-4906(26)00220-6. doi: 10.1016/j.it.2026.08.004. Online ahead of print. ABSTRACT Multiple myeloma remains incurable despite therapeutic advances. Longitudinal profiling of bone marrow and peripheral blood by Chander et al. reveals selective persistence of malignant plasma cell states, compartment-specific immune remodeling, incomplete humoral recovery after autologous stem cell transplantation, and divergent vaccine responses. PMID:42680673 … Read more

Trends Immunol. 2026 Aug 28:S1471-4906(26)00189-4. doi: 10.1016/j.it.2026.07.010. Online ahead of print. ABSTRACT Metastasis is an inefficient cellular process in which most disseminated tumor cells fail to form secondary lesions in distant tissues due to hostile conditions, such as protective immune surveillance. The few cells that survive these threats can seed subclinical metastatic lesions, known as … Read more

Trends Immunol. 2026 Aug 27:S1471-4906(26)00226-7. doi: 10.1016/j.it.2026.08.010. Online ahead of print. ABSTRACT Most individuals infected with Mycobacterium tuberculosis never develop active disease, yet the airway immune events determining outcome remain poorly understood. Branchett and colleagues prospectively profiled bronchoalveolar lavage from recent tuberculosis contacts, revealing that progression reflects a dynamic competition between opposing local immune states … Read more

Trends Immunol. 2026 Aug 19:S1471-4906(26)00215-2. doi: 10.1016/j.it.2026.08.002. Online ahead of print. ABSTRACT The underlying mechanism of tumor microenvironment-induced dysfunction of conventional type 1 dendritic cells (cDC1) remains unclear. Zhang et al. identify transforming growth factor β-driven coactivator-associated arginine methyltransferase 1 (CARM1) as an epigenetic inhibitor of cDC1 cross-presentation. CARM1 is a cell-intrinsic brake, and its … Read more

Trends Immunol. 2026 Aug 19:S1471-4906(26)00191-2. doi: 10.1016/j.it.2026.07.012. Online ahead of print. ABSTRACT Cytokines are key messenger molecules that bridge the nervous and immune systems through a bidirectional signalling network. Beyond their roles in development and homeostasis, neuronal cytokine sensing allows the central nervous system (CNS) to detect early immune perturbations, such as those triggered by … Read more