Trends Immunol. 2024 Nov 26:S1471-4906(24)00274-6. doi: 10.1016/j.it.2024.11.003. Online ahead of print.
ABSTRACT
The recent discovery by Lu and colleagues of Tomasiella immunophila, a bacterium that degrades IgA, offers insights into microbial influences on mucosal immunity and evolutionary immune trade-offs. By modulating IgA titers, T. immunophila influences the dynamic interactions and balance between the host and pathogen. This has implications for immune health, microbiome research, and therapeutics.
PMID:39603890 | DOI:10.1016/j.it.2024.11.003