Trends Immunol. 2025 Jan 27:S1471-4906(25)00023-7. doi: 10.1016/j.it.2025.01.005. Online ahead of print.
ABSTRACT
Lim and colleagues demonstrate that synNotch transcriptional circuits engineered into T cells can be used to precisely control location-specific expression of payloads responding to antigen triggers, thus locally inhibiting unwanted immunity or neuroinflammation. With no off-tumor toxicity or systemic immunosuppression upon elimination of mouse brain tumors, this approach can achieve better efficacy than anticipated.
PMID:39875238 | DOI:10.1016/j.it.2025.01.005