Curr Opin Immunol. 2025 Aug 14;96:102636. doi: 10.1016/j.coi.2025.102636. Online ahead of print.
ABSTRACT
Psoriasis is a chronic autoimmune skin disease characterized by abnormal proliferation and differentiation of keratinocytes, with a complex pathogenesis often linked to environmental and genetic factors. Although many treatments are available, the disease still exhibits a high recurrence rate. Epigenetic regulation appears to bridge external stimuli and genetic abnormalities in the development of psoriasis. Skin-resident cells may contribute to disease recurrence through an ‘inflammatory memory’ formed through epigenetic modifications. This review focuses on skin-resident cells in psoriasis, elucidating their roles in disease progression and recurrence from an epigenetic perspective, providing scientific evidence for targeted therapies.
PMID:40816133 | DOI:10.1016/j.coi.2025.102636