inmunoadmin

New developments and future directions in the management of systemic lupus erythematosus

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Curr Opin Immunol. 2026 Apr 14;100:102774. doi: 10.1016/j.coi.2026.102774. Online ahead of print. ABSTRACT Systemic lupus erythematosus (SLE) is a systemic autoimmune disorder with a pathogenesis that includes aberrant interactions between the innate and adaptive immune systems. Dominant pathogenetic axes include the type I interferon pathway and loss of tolerance in B cell/plasma cell development with … Read more

Modulation of rhesus macaque killer cell immunoglobulin-like receptor-MHC I interactions by simian immunodeficiency virus peptides

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J Immunol. 2026 Apr 15;215(4):vkag053. doi: 10.1093/jimmun/vkag053. ABSTRACT Natural killer (NK) cells are key effectors of innate immunity and contribute to early control of viral infections. Their activity is regulated in part by interactions between killer cell immunoglobulin-like receptors (KIRs) on NK cells and major histocompatibility complex class I (MHC I) molecules on target cells. … Read more

Folate receptor beta drives NLRP3 inflammasome activation and pyroptosis in macrophages independent of folate binding

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J Immunol. 2026 Apr 15;215(4):vkag051. doi: 10.1093/jimmun/vkag051. ABSTRACT Folate receptor beta (FRβ), encoded by FOLR2, is selectively expressed in monocytes and macrophages, yet its function in innate immune signaling remains poorly defined. Here, we identify FRβ as a novel regulator of NLRP3 inflammasome activation and pyroptosis in human THP-1 macrophages. Using CRISPR/Cas9-mediated gene deletion, we … Read more

Neutrophil FcγRI expression as a determinant of oxidative responses in human blood​Sandrine Huot on 15 de April de 2026 at 10:00

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J Leukoc Biol. 2026 Apr 15:qiag048. doi: 10.1093/jleuko/qiag048. Online ahead of print. ABSTRACT Neutrophils express Fc receptors on their surface to trap immune complexes. While the roles of FcγRIIa and FcγRIIIb have extensively been studied in that context, that of FcγRI remains elusive. Recently, aggregated IgGs have been shown to induce rapid FcγRI up-regulation and … Read more

A global perspective on autoimmunity and immunodeficiency: exploring geoepidemiology trends

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Curr Opin Immunol. 2026 Apr 13;100:102773. doi: 10.1016/j.coi.2026.102773. Online ahead of print. ABSTRACT Autoimmune and primary immunodeficiency disorders represent a growing global health burden influenced by a complex interplay of genetic, environmental, and socioeconomic factors. This paper offers a geoepidemiological analysis of these conditions, highlighting regional differences in incidence, diagnosis, and outcomes. Immunodeficiencies such as … Read more

Increased Constitutive Interferon‐β Levels and Altered CD4 T Cell Homeostasis Induced by Expression of a Viral Glycoprotein. [[{“value”:”Hanspeter Pircher, Oliver S. Thomas, Anne S. Haefke, Annette Oxenius, Thomas Boehm”}]]

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Constitutive interferon (IFN) production is regulated by microbiota and essential for optimal immune responses. Here, we demonstrate that expression of the glycoprotein of LCM virus upregulates constitutive IFN-β levels and IFN-stimulated genes (ISGs) in transgenic mice. Moreover, it increased self-antigen-driven memory-phenotype CD4 T cells and effector regulatory CD4 T cells. ABSTRACT Besides the strong Type … Read more

Effectiveness and immunogenicity of a nanoemulsion protein subunit vaccine against Pseudomonas aeruginosa: investigation in diet-induced obese mice

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J Immunol. 2026 Mar 17;215(3):vkag052. doi: 10.1093/jimmun/vkag052. ABSTRACT Pseudomonas aeruginosa (Pa) is an opportunistic pathogen threatening individuals with obesity, a condition associated with chronic meta-inflammation and altered immunity. In this study, we evaluate the immunogenicity and protective efficacy of a nanoemulsion-based subunit vaccine (L-PaF/ME/BECC) targeting Pa in a diet-induced obese mouse model. Mice fed a … Read more

CD160-competent ILC2 are crucial for the ejection of intestinal helminths by the innate immune system. Lennart Heepmann

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Mucosal Immunol. 2026 Apr 11:S1933-0219(26)00042-5. doi: 10.1016/j.mucimm.2026.04.005. Online ahead of print. ABSTRACT 1.6 billion people are currently infected with parasitic worms. Group 2 innate lymphoid cells (ILC2) play a central role in promoting the protective type 2 immunity against these parasites. Here we show that a subpopulation of intestinal ILC2 express the immune checkpoint molecule … Read more

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