inmunoadmin

Dysregulated MUC5B and MUC5AC impair epithelial barrier function and alter granulocyte frequency and activation in the lung and distal sites. Neeraj Patil

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Mucosal Immunol. 2026 Jul 18:100385. doi: 10.1016/j.mucimm.2026.100385. Online ahead of print. ABSTRACT BACKGROUND: Mucus obstructs the airways in respiratory diseases where MUC5B is the major gel-forming mucin in COPD and MUC5AC-rich mucus dominates in asthma. Mucin production changes in response to inflammatory signals, but whether mucin dysregulation drives inflammation is less studied. OBJECTIVE: We sought … Read more

Accumulation of mucosal and lymphoid hypo-functional granzyme K producing CD8+ effector memory T cells in idiopathic pulmonary fibrosis. Jetina Okereke

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Mucosal Immunol. 2026 Jul 17:100387. doi: 10.1016/j.mucimm.2026.100387. Online ahead of print. ABSTRACT Idiopathic pulmonary fibrosis is a progressive lung disease characterized by the rapid scarring of the lung parenchyma resulting in impaired gas exchange and early mortality. Current treatment options are limited; lung transplantation remains the only definitive treatment. The adaptive immune system has been … Read more

Fluorescence tracking CD8 T cells from tumor-draining lymph nodes to irradiated tumors and their activation in the tumor environment

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J Immunol. 2026 Jul 10;215(7):vkag142. doi: 10.1093/jimmun/vkag142. ABSTRACT Radiation is an effective site-specific cytotoxic therapy for cancer cells. In preclinical models, CD8 T cells are essential for optimum tumor control by radiation therapy, yet CD8 T cells are radiosensitive and depleted within the treatment field. Irradiated tumors can be refilled with T cells that were … Read more

Single-cell analysis of ovarian immune cells reveals dynamic changes in NK and B-cell populations after ovarian stimulation

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J Immunol. 2026 Jul 10;215(7):vkag153. doi: 10.1093/jimmun/vkag153. ABSTRACT The mammalian ovary is the dynamic end-organ of the hypothalamic-pituitary-ovarian axis. In this coordinated system, ovarian cells undergo continuous cycles of apoptosis, proliferation, and differentiation. These changes parallel fluctuations in ovarian hormones such as estradiol; however, the ovarian immune microenvironment during high- and low-estradiol states remains incompletely … Read more

The transcription factor SREBP2 supports the activation and homeostasis of CD4+ Foxp3+ regulatory T cells

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J Immunol. 2026 Jul 10;215(7):vkag181. doi: 10.1093/jimmun/vkag181. ABSTRACT Periodic activation of regulatory T cells (Tregs) is necessary to restrict autoreactive T cells and maintain immune homeostasis. IL-2-STAT5 signaling instructs several metabolic processes underlying Treg activation, including the mevalonate pathway, which is crucial for optimal Treg responses. However, direct links between IL-2-STAT5, mevalonate, and Treg function … Read more

PARI deficiency leads to increased somatic hypermutation

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J Immunol. 2026 Jul 10;215(7):vkag031. doi: 10.1093/jimmun/vkag031. ABSTRACT Somatic hypermutation of immunoglobulin (Ig) genes in germinal center B cells is based on the introduction of DNA lesions by activation-induced cytidine deaminase (AID), followed by lesion processing by multiple error-prone DNA repair pathways. Error-free DNA repair by homologous recombination (HR) is required for the repair of … Read more

T-cell miR-155 regulates the response to tumor-specific mRNA vaccines in a murine model of acute myeloid leukemia

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J Immunol. 2026 Jul 10;215(7):vkag184. doi: 10.1093/jimmun/vkag184. ABSTRACT Acute myeloid leukemia (AML) is a malignant clonal expansion of myeloid progenitor cells that impedes normal hematopoiesis and culminates in bone marrow failure and death. The development of chemoresistant disease in response to first-line chemotherapies is common and indicates a need for new therapies. Tumor-specific mRNA vaccines … Read more

mTECs and B cells form a thymic microniche associated with B-cell licensing

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J Immunol. 2026 Jul 10;215(7):vkag185. doi: 10.1093/jimmun/vkag185. ABSTRACT Thymic B cells rely on T cells and type-III IFN (IFN-λ) signaling for class switch recombination and effective licensing as APCs, a process essential for their role in establishing central T-cell tolerance. IFN-λ is produced exclusively by a subset of medullary thymic epithelial cells (mTECs); however, the … Read more

Hidden effects of polymyxin B: Its role in activating TLR2-mediated inflammatory responses

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J Immunol. 2026 Jul 10;215(7):vkag193. doi: 10.1093/jimmun/vkag193. ABSTRACT Polymyxins are cyclic cationic lipopeptide antibiotics that disrupt both the outer and inner membranes of Gram-negative bacteria. They also bind to bacterial lipopolysaccharides (LPSs), thereby inhibiting LPS recognition by Toll-like receptor 4 (TLR4) and preventing macrophage activation. However, the immunomodulatory effects of polymyxin B during infection, in … Read more

IgG4-Related Hepatic Disease Unmasking Hepatic Actinomycosis

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J Clin Immunol. 2026 Jul 18. doi: 10.1007/s10875-026-02049-3. Online ahead of print. ABSTRACT PURPOSE: Hepatic actinomycosis is a rare granulomatous disease caused by an opportunistic Gram-positive bacillus of the genus Actinomyces. We report an unusual association between hepatic actinomycosis and IgG-4 related disease. CASE DESCRIPTION: A 70-year-old man was admitted to the University Hospital of … Read more

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