inmunoadmin

SIV infection induces aging-like alterations in cardiac cellularity and macrophage populations of rhesus macaques​Daniel I Petkov on 5 de June de 2026 at 10:00

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J Leukoc Biol. 2026 Jun 5:qiag069. doi: 10.1093/jleuko/qiag069. Online ahead of print. ABSTRACT People living with HIV experience an earlier risk for onset of aging-related chronic inflammatory comorbidities including cardiovascular disease. We previously showed that the proportion of macrophages was higher in the heart of older rhesus macaques (Macaca mulatta) with normal histopathology as well … Read more

Hantavirus on the rise: clinical, virological, immunological, and public health perspectives

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Curr Opin Immunol. 2026 Jun 4;101:102804. doi: 10.1016/j.coi.2026.102804. Online ahead of print. ABSTRACT Hantaviruses are enveloped, negative-sense RNA viruses. Rodents serve as natural reservoirs, and spillover into humans causes hemorrhagic fever with renal syndrome and hantavirus pulmonary syndrome. While transmission typically occurs by inhaling aerosolized rodent excreta, the Andes virus variant is capable of human-to-human … Read more

Tuft cells protect against intestinal inflammation through histone deacetylase 3. Emily M Eshleman

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Mucosal Immunol. 2026 Jun 3:100356. doi: 10.1016/j.mucimm.2026.100356. Online ahead of print. ABSTRACT While intestinal tuft cells are well known to promote type 2 immunity, their role in inflammatory bowel disease (IBD) remains unclear. Here, we show that tuft cells are reduced in the distal intestine of pediatric IBD patients and that tuft cell-deficient mice exhibited … Read more

Glucocorticoid-driven gene expression in circulating monocytes and neutrophils in health and severe inflammation​Arthur Molendijk on 4 de June de 2026 at 10:00

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J Leukoc Biol. 2026 Jun 4:qiag068. doi: 10.1093/jleuko/qiag068. Online ahead of print. ABSTRACT Glucocorticoids (GCs) are used as anti-inflammatory and immunosuppressive drugs in many immune mediated diseases, but their use in sepsis and shock is controversial. This is caused in part by a lack of information regarding the responding cell types and GC-regulated genes in … Read more

PGRN promotes host defense against B. thailandensis-induced sepsis by augmenting macrophage antibacterial capacity via JAK1-STAT3 pathway

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J Immunol. 2026 May 14;215(5):vkag069. doi: 10.1093/jimmun/vkag069. ABSTRACT Burkholderia thailandensis (B. thailandensis) is an emerging pathogen. Although it has not yet caused large-scale outbreaks, severe infections can lead to sepsis. Currently, there are no effective treatment strategies available, highlighting the urgent need to develop novel therapies. Progranulin (PGRN) is a multifunctional protein with complex roles … Read more

A Unique Intraexonic Splicing Mechanism in the Immunoglobulin Domain of NKp30 Produces a Surface‐Expressed Receptor With Altered Ligand Specificity. [[{“value”:”Elisabeth G. Bjørnsen, Ellen Sofie Pete, Hanna Chan, Marit Inngjerdingen, Tatyana Sandalova, Anne Spurkland, Michael R. Daws, Adnane Achour, Andreas Lossius, Erik Dissen”}]]

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The immunoglobulin (Ig) domain exon of human NKp30 contains internal splice sites. A unique intraexonic splicing mechanism produces a short Ig domain that lacks 25 residues but maintains the Ig-fold structure and is expressed on the cell surface. Unlike full-length NKp30, the short version (NKp30-S) does not bind the cancer cell ligand B7H6. ABSTRACT The … Read more

Spatial omics of immunity: Mapping cellular landscapes in tissue microenvironments

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Curr Opin Immunol. 2026 Jun 2;101:102790. doi: 10.1016/j.coi.2026.102790. Online ahead of print. ABSTRACT The tumor microenvironment (TME) is composed of diverse heterogeneous components and plays a crucial role in immune cell infiltration, immune evasion, and dynamic interactions between tumor cells and the immune system. A precise understanding of the TME is essential for tissue immunology … Read more

Localization of TCR-expressing natural intraepithelial lymphocytes in the colon epithelium depends on GPR15 and epithelium-derived C10ORF99. Gerald J O’Connor

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Mucosal Immunol. 2026 Jun 1:100355. doi: 10.1016/j.mucimm.2026.100355. Online ahead of print. ABSTRACT Intraepithelial lymphocytes (IELs) are among the largest lymphocyte populations in the body and play a crucial role in maintaining the integrity of epithelial barriers at mucosal sites, which are highly immunostimulatory. Therefore, understanding how these cells are generated, localized within the epithelium, and … Read more

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