Diabetes and immunity: Decoding immunometabolism for precision intervention. Delia Goletti
Semin Immunol. 2026 Sep 3:102058. doi: 10.1016/j.smim.2026.102058. Online ahead of print. NO ABSTRACT PMID:42692896 | DOI:10.1016/j.smim.2026.102058
inmunoadmin
Differential responses of liver versus lymphoid tissue DC to small extracellular vesicles generated by hepatic ischemia-reperfusion injury
J Immunol. 2026 Aug 29;215(9):vkag224. doi: 10.1093/jimmun/vkag224. ABSTRACT Hepatic ischemia-reperfusion (I/R) injury triggers release of small extracellular vesicles (sEVs) that can function as systemic conveyors of inflammatory signals. While sEV-mediated immune cell modulation has been studied extensively in vitro, knowledge is based largely on sEVs derived from cultured cells, rather than injured tissues. Consequently, the … Read more
A Sampling of Highlights from the Literature: Article Recommendations from Our Deputy and Senior Editors
Cancer Immunol Res. 2026 Sep 2;14(9):1369. doi: 10.1158/2326-6066.CIR-14-9-WWR. NO ABSTRACT PMID:42682071 | DOI:10.1158/2326-6066.CIR-14-9-WWR
Cellular and Humoral Immune Responses to Noncanonical Enterotoxigenic Escherichia coli Virulence Factors. [[{“value”:”Saman Riaz, Sehee Rim, Hans Steinsland, Oda Barth Vedøy, Tim J. Vickers, James M. Fleckenstein, Kurt Hanevik”}]]
Circulating antigen-reactive CD4+ T cells and antibody responses in serum and lavage against the ETEC noncanonical virulence factors EatA, EtpA, and YghJ were found in volunteers experimentally infected with ETEC. This documents the immunogenicity of these antigens and supports their further evaluation as ETEC vaccine candidates. ABSTRACT A broadly protective licensed vaccine against enterotoxigenic Escherichia … Read more
Tracking tumor and immune remodeling through myeloma therapy. Jian Cui
Trends Immunol. 2026 Sep 1:S1471-4906(26)00220-6. doi: 10.1016/j.it.2026.08.004. Online ahead of print. ABSTRACT Multiple myeloma remains incurable despite therapeutic advances. Longitudinal profiling of bone marrow and peripheral blood by Chander et al. reveals selective persistence of malignant plasma cell states, compartment-specific immune remodeling, incomplete humoral recovery after autologous stem cell transplantation, and divergent vaccine responses. PMID:42680673 … Read more
A skin-kidney neutrophil axis links ultraviolet exposure to renal angiogenesis and tissue remodeling in healthy and lupus kidneys
J Immunol. 2026 Aug 29;215(9):vkag178. doi: 10.1093/jimmun/vkag178. ABSTRACT Neutrophils have been implicated in mediating immune crosstalk between injured tissue and distal organs, either promoting local and distal inflammation or mediating tissue repair. Skin injury from ultraviolet (UV) light triggers neutrophil migration to the kidney, which may have implications for nephritis flares in systemic lupus erythematosus. … Read more
Immune Dysregulation in Down Syndrome: Implications for Infectious Susceptibility and Vaccine Response
J Clin Immunol. 2026 Jul 24;46(1):86. doi: 10.1007/s10875-026-02054-6. ABSTRACT Down syndrome (DS), caused by trisomy 21, is characterized by complex immune dysregulation that increases susceptibility to infections and alters vaccine responsiveness. Gene dosage effects involving interferon receptor loci on chromosome 21 contribute to chronic type I interferon hyperactivation, sustained JAK-STAT signaling, and persistent expression of … Read more
Neutralizing the IL-12/IL-23 p40 subunit prevents immune checkpoint blockade toxicity without compromising antitumor efficacy
Cancer Immunol Res. 2026 Aug 31. doi: 10.1158/2326-6066.CIR-26-0177. Online ahead of print. ABSTRACT Immune checkpoint blockade (ICB) has markedly improved overall survival in various cancers, but is associated with severe and sometimes fatal immune-related adverse events (irAEs). Current management of irAEs involves discontinuation of ICB therapy and administration of immunosuppressive drugs, such as corticosteroids, which … Read more
CD266+ myofibroblasts mediate resistance to immunochemotherapy through ECM stiffness in head and neck squamous cell carcinoma
Cancer Immunol Res. 2026 Aug 31. doi: 10.1158/2326-6066.CIR-25-1379. Online ahead of print. ABSTRACT The efficacy of immunotherapy in unresectable/recurrent/metastatic head and neck squamous cell carcinoma (U/R/M HNSCC) remains suboptimal compared to primary untreated resectable HNSCC. The immunological and stromal landscape during immunotherapy in U/R/M HNSCC is crucial for understanding drug resistance mechanisms. In this study, … Read more
A High Density of Impaired Tertiary Lymphoid Structures Is Associated with Higher Tumor Stage and Recurrence in Non-Muscle-Invasive Bladder Cancer
Cancer Immunol Res. 2026 Aug 31. doi: 10.1158/2326-6066.CIR-26-0104. Online ahead of print. ABSTRACT Tertiary lymphoid structures (TLS) have emerged as critical immune niches within the tumor microenvironment across various cancers. However, their structural organization and functional roles in non-muscle-invasive bladder cancer (NMIBC) remain poorly characterized. In this study, we comprehensively characterized TLS in NMIBC using … Read more