inmunoadmin

Long-term Nlrp3 gain-of-function mutation promotes cardiac dysfunction independent of inflammasome in mice

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J Immunol. 2026 Oct 1;215(10):vkag257. doi: 10.1093/jimmun/vkag257. ABSTRACT Cryopyrin-associated periodic syndrome (CAPS) is an autoinflammatory disease caused by gain-of-function mutations in human nucleotide-binding domain, leucine-rich repeat-containing protein 3 (NLRP3), which lead to constitutive inflammasome activation and excessive IL-1β secretion. Long-term IL-1 blockade has markedly improved patient outcomes by preventing systemic inflammation and amyloidosis. However, whether … Read more

Differential requirements for cytokine signaling and local antigen in upper versus lower respiratory tract CD8+ TRM development

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J Immunol. 2026 Oct 1;215(10):vkag269. doi: 10.1093/jimmun/vkag269. ABSTRACT CD8+ tissue-resident memory T cells (TRM) in the upper respiratory tract (URT) limit viral replication after transmission and prevent spread to the lower respiratory tract (LRT), whereas LRT CD8+ TRM are important for limiting immunopathology in the lung and promoting efficient viral clearance. Although the presence of … Read more

CTLA4 rs3087243-A-linked haplotype is associated with increased CTLA-4 expression and suppressive function in human regulatory T cells

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J Immunol. 2026 Oct 1;215(10):vkag276. doi: 10.1093/jimmun/vkag276. ABSTRACT CTLA-4 is an inhibitory receptor on T cells that limits immune activation by competing with the co-stimulatory receptor CD28 for binding to CD80 and CD86 on antigen-presenting cells. Regulatory T cells (Tregs) employ CTLA-4-mediated transendocytosis as a key suppressive mechanism. Several CTLA4 polymorphisms are associated with autoimmune … Read more

TCRαβ repertoire plasticity defines universal CD8+ T cell responses directed at influenza-specific HLA-A*02:01-PB1413-421 epitope

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J Immunol. 2026 Oct 1;215(10):vkag270. doi: 10.1093/jimmun/vkag270. ABSTRACT HLA-A*02:01-restricted PB1413+CD8+ T cells provide the broadest reported cross-reactive immunity against influenza A, B, and C viruses. Here, we investigated T cell receptor (TCR) clonotypic signatures within these universal A2/PB1413+CD8+ T cell pools, compared with immunodominant influenza A-specific M158+CD8+ T cells and codominant influenza B-specific A2/HA543+CD8+ memory … Read more

TNFα promotes brain-predominant EAE independent of IFNγ and IL-17A in HLA-DR3 transgenic mice

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J Immunol. 2026 Oct 1;215(10):vkag268. doi: 10.1093/jimmun/vkag268. ABSTRACT Multiple sclerosis (MS) is thought to be mediated by human leukocyte antigen (HLA) class II-restricted autoreactive CD4 T cells producing interleukin (IL)-17A and/or interferon γ (IFNγ), but the necessity of these cytokines for disease pathogenesis is unclear. Utilizing HLA-DR3 (DRβ1*0301) transgenic mice lacking IFNγ or IL-17A in … Read more

Transient manganese exposure reprograms bone marrow-derived macrophages toward a stable anti-inflammatory memory state

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J Immunol. 2026 Oct 1;215(10):vkag267. doi: 10.1093/jimmun/vkag267. ABSTRACT Manganese ions (Mn2+) are potent immunomodulatory agents that activate the cGAS-STING pathway. While their role as acute adjuvants is well-documented, the innate immune memory (trained immunity) signatures induced by Mn2+ remain unexplored. Using an in vitro priming-rest-challenge model, we demonstrate that transient Mn2+ stimulation induces a persistent … Read more

Discovery of Avian TCRVβ2+ T Cells Recognizing the Endogenous Ganglioside via a chCD1.1‐Dependent Pathway. [[{“value”:”Nitin Kamble, Faisal R Anjum, Shahriar Behboudi”}]]

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We present the first report of chicken lipid-reactive, NKT-like TCRVβ2+ T cells that recognize the endogenous ganglioside GM3 presented by chCD1.1 on live antigen-presenting cells. This activation induces a rapid cytokine response from avian lipid-reactive T cells, offering a universal target for lipid-adjuvanted poultry vaccines. ABSTRACT This study presents the discovery and first functional characterization … Read more

Inducible cAMP Early Repressor Limits Glycolytic Programming in Regulatory T Cells and Supports Control of Inflammatory Colitis. [[{“value”:”Aleksandra Lopez Krol, Luana Silva, Daniele C. Nascimento, Sophie M. Oberwalder, Hitikk Chawla, Gabriel Alberto Barbosa de Carvalho, Fatima Boukhallouk, Monica Romero, Anne Hausen, Matthias M. Gaida, Luciana Berod, José Carlos Alves‐Filho, Tim Sparwasser”}]]

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This study is focussed on the role of cAMP-dependent transcriptional repressor ICER in regulatory T cell function. Using a conditional knockout model, Treg development, suppressive function, stability, and metabolic phenotype were examined to gain further understanding of the role of cAMP-dependent signalling in regulatory T cells. ABSTRACT Regulatory T cells (Tregs) are essential for immune … Read more

Ptpn1 deficiency collaborates with a NUP98::HOXD13 fusion gene to generate B cell precursor acute lymphoblastic leukemia

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J Immunol. 2026 Oct 1;215(10):vkag250. doi: 10.1093/jimmun/vkag250. ABSTRACT B cell precursor acute lymphoblastic leukemia (BCP ALL) is driven by a combination of genetic alterations that promote invasion and expansion of undifferentiated B cells. Mice that express a NUP98::HOXD13 (NHD13) fusion gene in hematopoietic cells develop a wide range of hematologic malignancy, and when crossed to … Read more

CRISPR-Cas9 screen identifies eIF4G2 as a regulator of CD8+ T cell dysfunction

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J Immunol. 2026 Oct 1;215(10):vkag187. doi: 10.1093/jimmun/vkag187. ABSTRACT CD8+ T cells directly target and kill cancer cells and are required for effective antitumor immunity. However, CD8+ T cells may become dysfunctional when exposed to chronic antigen stimulation during cancer. Dysfunction is characterized by reduced proliferation, increased expression of inhibitory receptors, and impaired effector function, yet … Read more

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