inmunoadmin Trends Immunol. 2025 Apr 18:S1471-4906(25)00079-1. doi: 10.1016/j.it.2025.03.005. Online ahead of print. ABSTRACT A genealogy of immunity reveals increasingly complex systems for pathogen response, organism homeostasis, and multispecies interaction. New studies show how the five senses can all contribute to behavioral, shared and population level immunity redefining our understanding of the ways organisms communicate among and … Read more
J Immunol. 2025 Apr 18:vkaf046. doi: 10.1093/jimmun/vkaf046. Online ahead of print. ABSTRACT T helper cell differentiation is one of the key developmental events in the peripheral immune regulations, resulting in better adaptation to the nature of infection and inflammation. While it is known that several factors are involved in this differentiation, including subsets of antigen-presenting … Read more
J Immunol. 2025 Apr 18:vkaf042. doi: 10.1093/jimmun/vkaf042. Online ahead of print. ABSTRACT Inflammasomes are multiprotein innate immune complexes formed in response to infections, tissue damage, or cellular stress that promote the maturation and release of IL-1β/IL-18 and are implicated in lytic cell death. The NLRP3 inflammasome is canonically activated by an initial priming event followed … Read more
Cancer Immunol Res. 2025 Apr 18:OF1-OF20. doi: 10.1158/2326-6066.CIR-24-0630. Online ahead of print. ABSTRACT Detection of disseminated cancer cells (DCC) in the bone marrow (BM) of patients with breast cancer is a critical predictor of late recurrence and distant metastasis. Conventional therapies often fail to completely eradicate DCCs in patients. In this study, we demonstrate that … Read more
Cancer Immunol Res. 2025 Apr 18. doi: 10.1158/2326-6066.CIR-24-0387. Online ahead of print. ABSTRACT Although initially assumed to be similar, immune checkpoint inhibitor (ICI)-induced autoimmunity can differ from spontaneous autoimmune disease regarding clinical presentation, pathogenesis and therapy. Despite limited pathogenetic understanding, ICI-induced colitis (irColitis), a common adverse event during ICI therapy, is treated analogously to its … Read more
J Immunol. 2025 Apr 17:vkaf036. doi: 10.1093/jimmun/vkaf036. Online ahead of print. ABSTRACT Natural killer (NK) cells are emerging as a promising tool for cancer immunotherapy due to their innate ability to selectively recognize and eliminate cancer cells. Over the past 3 decades, strategies to harness NK cells have included cytokines, small molecules, antibodies, and the … Read more
J Leukoc Biol. 2025 Apr 17:qiaf049. doi: 10.1093/jleuko/qiaf049. Online ahead of print. ABSTRACT Neutrophils are the most abundant leukocytes in the circulation and critical players in host defense and inflammation. They respond rapidly to numerous biological, chemical, and physical stimuli, making it challenging to characterize their steady-state phenotypes, activation states, and subsets in an unbiased … Read more
J Leukoc Biol. 2025 Apr 17:qiaf047. doi: 10.1093/jleuko/qiaf047. Online ahead of print. ABSTRACT Bone marrow-derived dendritic cell (BMDC) activation is associated with rewiring of cellular metabolism and concurrent large-scale changes in gene expression promoting a pro-inflammatory program characterized by expression of inducible nitric oxide synthase (iNOS) and the production of nitric oxide (NO). NO inhibits … Read more
Curr Opin Immunol. 2025 Apr 15;94:102558. doi: 10.1016/j.coi.2025.102558. Online ahead of print. ABSTRACT The brain harbors two major macrophage populations: microglia reside within the brain parenchyma, while border-associated macrophages (BAMs) are situated at central nervous system (CNS) interfaces. BAMs can be further classified into distinct subsets based on their localization: perivascular macrophages surround blood vessels, … Read more
Trends Immunol. 2025 Apr 15:S1471-4906(25)00081-X. doi: 10.1016/j.it.2025.03.007. Online ahead of print. ABSTRACT Epstein-Barr virus (EBV) was the first DNA virus identified to be tightly associated with multiple human tumors. It promotes malignant progression of tumors – including related lymphomas, nasopharyngeal carcinoma, and gastric adenocarcinoma – in part by evading surveillance and attack by the host … Read more
