Curr Opin Immunol. 2025 Sep 15;97:102658. doi: 10.1016/j.coi.2025.102658. Online ahead of print.
ABSTRACT
Psoriatic arthritis (PsA) is a multifaceted autoimmune condition that affects the peripheral and axial joints, entheses, skin, and nails. The management of PsA relies on prompt diagnosis and early initiation of effective treatment to minimize joint destruction. Treatment options for PsA are rapidly evolving and emerging. This review will discuss screening tools, early diagnosis/outcome measures, and treatment guidelines for PsA, including the most recent EULAR/GRAPPA/ACR recommendations. Advances in science and technology are also rapidly changing the landscape of medicine, and we have discussed how targeted therapies, smartphone monitoring, and artificial intelligence could benefit PsA monitoring and treatment. Finally, we discussed the concept of treating PsA as a multisystem disorder with a multidisciplinary team of specialists and implementation of a ‘Total Care’ program. Overall, this review highlights the evolving treatment frameworks in PsA, advocating for early detection, comprehensive assessment, and targeted therapy that can improve patient outcomes and quality of life.
PMID:40961619 | DOI:10.1016/j.coi.2025.102658