Cai, Z., Lin, K., Dong, X., Li, Z., Chen, G., Guo, L., Mou, P., Chen, P., Huang, J., Li, L., Liu, X., Tang, R., Zeng, Y.

Implantable artificial lymph node enables rapid in vivo neoantigen-specific T-cell generation and expansion for improving antitumor immunity

31 de December de 2025 by Cai, Z., Lin, K., Dong, X., Li, Z., Chen, G., Guo, L., Mou, P., Chen, P., Huang, J., Li, L., Liu, X., Tang, R., Zeng, Y.

Background
Tumor neoantigen vaccines typically require multiple prime-boost immunizations over several weeks or even months to elicit sufficient neoantigen-specific T-cell responses, which greatly limits their effectiveness against rapidly progressing…