Cao, S., Sun, Z., Hu, W., Xue, D., Yang, Z., Duan, P., Peng, H., Fu, Y.-X., Liang, Y.

Dual targeting OX40 and IL-2 receptor enhances antitumor activity through tumor-infiltrating Treg depletion and CD8+ T-cell proliferation

16 de September de 2025 by Cao, S., Sun, Z., Hu, W., Xue, D., Yang, Z., Duan, P., Peng, H., Fu, Y.-X., Liang, Y.

Background
The strong regulatory T cell (Treg) inhibitory activity and dysfunctional cytotoxic T lymphocytes (CTLs) represent major barriers to effective antitumor immunity, particularly in late-stage cancer. Multiple anti-OX40 (aOX40) agonistic antib…