Chen, T., Wang, Y., Chen, X., Li, Y., Guo, J., Liu, F., Shao, J., Yan, J., Li, M., Nie, J., Sun, Q., Liu, Q., Liu, B.

Non-superagonist CD28-based dual-signal T cell engager targeting

20 de January de 2026 by Chen, T., Wang, Y., Chen, X., Li, Y., Guo, J., Liu, F., Shao, J., Yan, J., Li, M., Nie, J., Sun, Q., Liu, Q., Liu, B.

Background
Bispecific T cell engagers have demonstrated promising clinical progress in both hematologic malignancies and solid tumors; however, their therapeutic efficacy is still limited by multiple challenges including T cell anergy resulting from s…

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