Ciccone, D. N., Kuo, F.-S., Boiko, S., Carreiro, S., Kaila, N., McElwee, J. J., Tummino, P. J., Loh, C.

Highly selective HPK1 inhibitor NDI-101150 mediates immune cell activation and robust antitumor responses, distinct from immune checkpoint blockade

30 de July de 2025 by Ciccone, D. N., Kuo, F.-S., Boiko, S., Carreiro, S., Kaila, N., McElwee, J. J., Tummino, P. J., Loh, C.

Background
HPK1 (hematopoietic progenitor kinase 1, MAP4K1), an MAP4K serine/threonine kinase family member, is a negative regulator of immune cell function. Genetic HPK1 kinase inactivation or knockout in mice leads to immune cell activation and tumo…