Feng, H.-M., Zhao, Y., Zhai, K.-R., Li, B., Song, T.-N., Meng, Y.-Q., Huang, H.-R., Li, Z., Cui, B.-Q., Yang, N., Su, Z.-P.

Extracellular granzyme K enhances PD-L1 transcription and stability via F2RL1 activation to facilitate tumor immune evasion in lung adenocarcinoma

12 de January de 2026 by Feng, H.-M., Zhao, Y., Zhai, K.-R., Li, B., Song, T.-N., Meng, Y.-Q., Huang, H.-R., Li, Z., Cui, B.-Q., Yang, N., Su, Z.-P.

Background
Granzyme K (GZMK) is a serine protease known for its perforin-dependent cytotoxicity. However, the non-cytotoxic role of GZMK in lung adenocarcinoma (LUAD) remains largely elusive.

Methods
Multiomics datasets were integrated to investigate…

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