He, J., Kirsche, L., Nascakova, Z., Manfredi, F., Magnani, C. F., Papa, G., Azizi, F., Leary, P., Müller, A.

Genetically engineered ErbB2 overexpression sensitizes organoid-derived tumors to checkpoint inhibition in a syngeneic model of gastric cancer

11 de February de 2026 by He, J., Kirsche, L., Nascakova, Z., Manfredi, F., Magnani, C. F., Papa, G., Azizi, F., Leary, P., Müller, A.

Background
ERBB2/HER2 is overexpressed or mutated in ~15% of gastric cancers due to amplification or mutation of the ERBB2 locus. While the tumor cell-intrinsic consequences of ERBB2 overexpression are well understood, much less is known about its eff…