inmunoadmin Curr Opin Immunol. 2024 Sep 13;91:102461. doi: 10.1016/j.coi.2024.102461. Online ahead of print. ABSTRACT T follicular helper (Tfh) cells help direct the production of antibodies by B cells. In addition to promoting antibody responses to vaccination and infection, Tfh cells have been found to mediate antibody production to food antigens. Work over the past decade has … Read more
Curr Opin Immunol. 2024 Sep 11;91:102462. doi: 10.1016/j.coi.2024.102462. Online ahead of print. ABSTRACT Signal integration is central to a causal understanding of appropriately scaled inflammatory responses. Here, we discuss recent progress in our understanding of the stimulus-response linkages downstream of pro-inflammatory inputs, with special attention to (1) the impact of cell state on the specificity … Read more
J Clin Immunol. 2024 Sep 27;45(1):18. doi: 10.1007/s10875-024-01809-3. ABSTRACT INTRODUCTION: This study investigates the frequency of hospital attendances, emergency care attendances and geographical influences on service interaction in cohorts of patients with primary and secondary antibody deficiency, to inform future service planning and delivery. METHODS: The COVID-19 in Antibody Deficiency (COV-AD) study was a United … Read more
J Clin Immunol. 2024 Sep 26;45(1):17. doi: 10.1007/s10875-024-01798-3. ABSTRACT BACKGROUND: Talaromyces marneffei (T. marneffei) is an opportunistic pathogen that causes endemic mycoses, which could lead to multiple organ damage. Talaromycosis is frequently disregarded as an early cautionary sign of immune system disorders in non-HIV-infected children. OBJECTIVE: We conduct a comprehensive review of the genotypes and … Read more
J Clin Immunol. 2024 Sep 25;45(1):16. doi: 10.1007/s10875-024-01807-5. ABSTRACT Immunodeficiency, centromeric region instability, facial anomalies syndrome (ICF), is a rare disease with autosomal recessive inheritance. ICF syndrome. It has been reported that ICF syndrome is caused by mutations in the DNMT3B (ICF1), ZBTB24 (ICF2), CDCA7 (ICF3), and HELLS (ICF4) genes. As a result of literature … Read more
J Clin Immunol. 2024 Sep 23;45(1):14. doi: 10.1007/s10875-024-01804-8. NO ABSTRACT PMID:39312089 | PMC:PMC11420255 | DOI:10.1007/s10875-024-01804-8
J Clin Immunol. 2024 Sep 23;45(1):15. doi: 10.1007/s10875-024-01793-8. ABSTRACT PURPOSE: PI4KA-related disorder is a highly clinically variable condition characterized by neurological (limb spasticity, developmental delay, intellectual disability, seizures, ataxia, nystagmus) and gastrointestinal (inflammatory bowel disease and multiple intestinal atresia) manifestations. Although features consistent with immunodeficiency (autoimmunity/autoinflammation and recurrent infections) have been reported in a subset … Read more
J Clin Immunol. 2024 Sep 21;45(1):13. doi: 10.1007/s10875-024-01805-7. ABSTRACT Natural antibodies (NAbs) occurring in individuals without prior exposure to specific antigens, provide direct first barrier protection against pathogens, and exert immunoregulation thus actively contributing to the maintenance of immune homeostasis, controlling inflammatory processes and preventing autoimmunity. Common variable immunodeficiency (CVID) is a heterogeneous group of … Read more
J Clin Immunol. 2024 Sep 20;45(1):12. doi: 10.1007/s10875-024-01806-6. ABSTRACT BACKGROUND: Hemophagocytic Lymphohistiocytosis (HLH) carries a high mortality rate. Current existing risk-evaluation methodologies fall short and improved predictive methods are needed. This study aimed to forecast 30-day mortality in adult HLH patients using 11 distinct machine learning (ML) algorithms. METHODS: A retrospective analysis on 431 adult … Read more
J Clin Immunol. 2024 Sep 19;45(1):11. doi: 10.1007/s10875-024-01801-x. NO ABSTRACT PMID:39297999 | PMC:PMC11413082 | DOI:10.1007/s10875-024-01801-x
