inmunoadmin

Curr Opin Immunol. 2024 Sep 25;91:102492. doi: 10.1016/j.coi.2024.102492. Online ahead of print. ABSTRACT The global prevalence of atopic diseases, including food allergy, is increasing and correlates with shifts in the commensal microbiota triggered by modern lifestyle factors. Current research focuses on the immunological mechanisms and microbial cues that regulate mucosal immunity and prevent allergic responses … Read more

Curr Opin Immunol. 2024 Sep 24;91:102493. doi: 10.1016/j.coi.2024.102493. Online ahead of print. ABSTRACT The prevalence of many chronic noncommunicable diseases has been steadily rising over the past six decades. During this time, humans have been increasingly exposed to substances toxic for epithelial cells, including air pollutants, laundry and dishwashers, household chemicals, toothpaste, food additives, microplastics, … Read more

Curr Opin Immunol. 2024 Sep 21;91:102487. doi: 10.1016/j.coi.2024.102487. Online ahead of print. ABSTRACT A simple definition of life is a system that can self-replicate (proliferation) and self-sustain (metabolism). At the cellular level, metabolism has evolved to drive proliferation, which requires energy and building blocks to duplicate cellular biomass before division. T lymphocytes (or T cells) … Read more

Curr Opin Immunol. 2024 Sep 16;91:102460. doi: 10.1016/j.coi.2024.102460. Online ahead of print. ABSTRACT Since the discovery of Toll and Toll-like receptors (TLRs) in the 90s, an extensive body of research has been performed to determine how Pattern Recognition Receptors (PRRs) recognise ‘ligands’ and signal. The families of PRRs now include membrane and cytosolic proteins, which … Read more

Curr Opin Immunol. 2024 Sep 13;91:102463. doi: 10.1016/j.coi.2024.102463. Online ahead of print. ABSTRACT In tumors, immune cells organize into networks of different sizes and composition, including complex tertiary lymphoid structures and recently identified networks centered around the chemokines CXCL9/10/11 and CCL19. New commercially available highly multiplexed microscopy using cyclical RNA in situ hybridization and antibody-based … Read more

Curr Opin Immunol. 2024 Sep 13;91:102471. doi: 10.1016/j.coi.2024.102471. Online ahead of print. ABSTRACT The microbiome regulates mammalian immune responses from early life to adulthood. Antigen presentation, orchestrating these responses, integrates commensal and pathogenic signals. However, the temporal and spatial specificity of microbiome impacts on antigen presentation and downstream tolerance versus inflammation remain incompletely understood. Herein, … Read more

Curr Opin Immunol. 2024 Sep 13;91:102461. doi: 10.1016/j.coi.2024.102461. Online ahead of print. ABSTRACT T follicular helper (Tfh) cells help direct the production of antibodies by B cells. In addition to promoting antibody responses to vaccination and infection, Tfh cells have been found to mediate antibody production to food antigens. Work over the past decade has … Read more

Curr Opin Immunol. 2024 Sep 11;91:102462. doi: 10.1016/j.coi.2024.102462. Online ahead of print. ABSTRACT Signal integration is central to a causal understanding of appropriately scaled inflammatory responses. Here, we discuss recent progress in our understanding of the stimulus-response linkages downstream of pro-inflammatory inputs, with special attention to (1) the impact of cell state on the specificity … Read more